Colorectal Liver Metastases

  • Saurabh Jamdar
  • Aali J. Sheen
  • Ajith K. Siriwardena


Colorectal cancer can metastasize to the liver by three potential routes; the most common are via the portal venous drainage of the liver and the lymphatic drainage of the large intestine with a third mechanism being direct invasion of the liver by a tumor of the hepatic flexure [1].


Liver Resection Colorectal Liver Metastasis Portal Vein Embolization Laparoscopic Liver Resection Future Remnant Liver 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Rudmick LR, Magliocco AM. Molecular mechanisms of hepatic metastasis in colorectal cancer. J Surg Oncol. 2005;92:347–59.CrossRefGoogle Scholar
  2. 2.
    Cancer Research UK Information Resource Centre. Cancer Stats. 2003. Accessed 5th October 2011.
  3. 3.
    Simmonds PC, Primrose JN, Colquitt JL, et al. Surgical resection of hepatic metastases from colorectal cancer: a systematic review of published studies. Br J Cancer. 2006;94:982–99.PubMedCrossRefGoogle Scholar
  4. 4.
    Treasure T. Pulmonary metastasectomy: a common practice based on weak evidence. Ann R Coll Surg Engl. 2007;89:744–8.PubMedCrossRefGoogle Scholar
  5. 5.
    Scheele J, Stangl R, Altendorf-Hofmann A. Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg. 1990;77:1241–6.PubMedCrossRefGoogle Scholar
  6. 6.
    Renehan AG, Egger M, Saunders MP, O’Dwyer ST. Impact on survival of intensive follow up after curative resection for colorectal cancer: systematic review and meta-analysis of randomised trials. BMJ. 2002;324:813.PubMedCrossRefGoogle Scholar
  7. 7.
    Gomez D, Sangha VK, Morris-Stiff G, et al. Outcomes of intensive surveillance after resection of hepatic colorectal metastases. Br J Surg. 2010;97:1552–60.PubMedCrossRefGoogle Scholar
  8. 8.
    Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999;230:309–18.PubMedCrossRefGoogle Scholar
  9. 9.
    Junejo M, Foster P, Moore J, et al. Cardiopulmonary exercise testing for risk assessment prior to hepatectomy. HPB. 2011; 13: Suppl 2 p84.Google Scholar
  10. 10.
    Valls C, Martίnez L, Ruiz S, Alba E. Radiological imaging of liver metastases. In: Vauthey J-N, Hoff PM, Audisio R, Poston GJ, editors. Liver metastases. London: Springer; 2009. p. 1–15.CrossRefGoogle Scholar
  11. 11.
    Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371:1007–16.PubMedCrossRefGoogle Scholar
  12. 12.
    Belgihiti J, Clavien PA, Gadzijev, et al. The Brisbane 2000 terminology of liver anatomy and resections. HPB. 2000;2:333–9.Google Scholar
  13. 13.
    Hamady ZZ, Cameron IC, Wyatt J, et al. Resection margin in patients undergoing hepatectomy for colorectal liver metastasis: a critical appraisal of the 1 cm rule. Eur J Surg Oncol. 2006;32:557–63.PubMedCrossRefGoogle Scholar
  14. 14.
    Buell JF, Cherqui D, Geller DA, et al. The international position on laparoscopic liver surgery: the Louisville Statement, 2008. Ann Surg. 2009;250:825–30.PubMedCrossRefGoogle Scholar
  15. 15.
    Sebag-Montefiore D, Stephens RJ, Steele R, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet. 2009;373:811–20.PubMedCrossRefGoogle Scholar
  16. 16.
    Bosset J-F, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355:1114–23.PubMedCrossRefGoogle Scholar
  17. 17.
    Allen PJ, Kemeny N, Jarnagin W, et al. Importance of response to neoadjuvant chemotherapy in patients undergoing resection of synchronous colorectal liver metastases. J Gastrointest Surg. 2003;7:109–15.PubMedCrossRefGoogle Scholar
  18. 18.
    Bismuth H, Adam R, Levi F, et al. Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann Surg. 1996;224:509–22.PubMedCrossRefGoogle Scholar
  19. 19.
    Chua TC, Saxena A, Chu F, Zhao J, Morris DL. Predictors of cure after hepatic resection of colorectal liver metastases: an analysis of actual 5- and 10-year survivors. J Surg Oncol. 2011. doi:10.1002/jso.21864 (Epub ahead of print).Google Scholar
  20. 20.
    Takahashi S, Konishi M, Nakagohri T, et al. Short time to recurrence after hepatic resection correlates with poor prognosis in colorectal hepatic metastasis. Jpn J Clin Oncol. 2006;36:368–75.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  • Saurabh Jamdar
    • 1
  • Aali J. Sheen
    • 2
  • Ajith K. Siriwardena
    • 3
  1. 1.Hepatobiliary Surgery Unit, Department of SurgeryManchester Royal InfirmaryManchesterUK
  2. 2.Hepatobiliary Surgery Unit, Department of SurgeryManchester Royal InfirmaryManchesterUK
  3. 3.Hepatobiliary Surgery Unit, Department of SurgeryManchester Royal InfirmaryManchesterUK

Personalised recommendations