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Sex and Gender Aspects in Clinical Medicine pp 17–44Cite as

Sex and Gender Differences in Cardiovascular Disease

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Abstract

Gender differences play a major role in the manifestation and outcomes of cardiovascular disease. We will focus on a few exemplary syndromes, such as heart failure (HF), and its most frequent causes such as hypertension, myocardial infarction (MI), coronary artery disease (CAD), on cardiomyopathies and atrial fibrillation. Hypertension, diabetes, and myocardial hypertrophy are the major risk factors for HF in women, whereas prior myocardial infarction is more relevant in men. Cardiomyopathies are a rare but particularly severe cause of HF leading to 50% of all transplantations for end-stage HF in both genders. This is by far not a complete list of cardiovascular diseases with major gender differences.

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References

  1. Regitz-Zagrosek V, Wintermantel TM, Schubert C. Estrogens and SERMs in coronary heart disease. Curr Opin Pharmacol. 2007;7(2):130-139.

    PubMed  CAS  Google Scholar 

  2. Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov. 2006;5(5):425-438.

    PubMed  CAS  Google Scholar 

  3. Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics–2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115(5):e69-e171.

    PubMed  Google Scholar 

  4. Anand SS, Islam S, Rosengren A, et al. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J. 2008;29(7):932-940.

    PubMed  Google Scholar 

  5. Heer T, Gitt AK, Juenger C, et al. Gender differences in acute non-ST-segment elevation myocardial infarction. Am J Cardiol. 2006;98(2):160-166.

    PubMed  Google Scholar 

  6. Hochman JS, McCabe CH, Stone PH, et al. Outcome and profile of women and men presenting with acute coronary syndromes: a report from TIMI IIIB. TIMI Investigators. Thrombolysis in myocardial infarction. J Am Coll Cardiol. 1997;30(1):141-148.

    PubMed  CAS  Google Scholar 

  7. Lowel H, Meisinger C, Heier M, et al. Sex specific trends of sudden cardiac death and acute myocardial infarction: results of the population-based KORA/MONICA-Augsburg register 1985 to 1998. Dtsch Med Wochenschr. 2002;127(44):2311-2316.

    PubMed  CAS  Google Scholar 

  8. Vaccarino V, Parsons L, Every NR, Barron HV, Krumholz HM. Sex-based differences in early mortality after myocardial infarction. National registry of myocardial infarction 2 participants. N Engl J Med. 1999;341(4):217-225.

    PubMed  CAS  Google Scholar 

  9. Theres H, Maier B, Matteucci Gothe R, et al. Influence of gender on treatment and short-term mortality of patients with acute myocardial infarction in Berlin. Z Kardiol. 2004;93(12):954-963.

    PubMed  CAS  Google Scholar 

  10. Setoguchi S, Solomon DH, Levin R, Winkelmayer WC. Gender differences in the management and prognosis of myocardial infarction among patients>or=65 years of age. Am J Cardiol. 2008;101(11):1531-1536.

    PubMed  Google Scholar 

  11. Juutilainen A, Kortelainen S, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Gender difference in the impact of type 2 diabetes on coronary heart disease risk. Diabetes Care. 2004;27(12):2898-2904.

    PubMed  Google Scholar 

  12. Hendricks AS, Goodman B, Stein JH, Carnes M. Gender differences in acute myocardial infarction: the University of Wisconsin experience. WMJ. 1999;98(8):30-33. 36.

    PubMed  CAS  Google Scholar 

  13. Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937-952.

    PubMed  Google Scholar 

  14. Njolstad I, Arnesen E, Lund-Larsen PG. Smoking, serum lipids, blood pressure, and sex differences in myocardial infarction. A 12-year follow-up of the Finnmark Study. Circulation. 1996;93(3):450-456.

    PubMed  CAS  Google Scholar 

  15. Prescott E, Hippe M, Schnohr P, Hein HO, Vestbo J. Smoking and risk of myocardial infarction in women and men: longitudinal population study. BMJ. 1998;316(7137): 1043-1047.

    PubMed  CAS  Google Scholar 

  16. Higginson R. Women’s help-seeking behaviour at the onset of myocardial infarction. Br J Nurs. 2008;17(1):10-14.

    PubMed  Google Scholar 

  17. Samani NJ, Erdmann J, Hall AS, et al. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357(5):443-453.

    PubMed  CAS  Google Scholar 

  18. Deinum J, von Gool JM, Kofflard MJ, ten Cate F, Danser J. Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy. Hypertension. 2001;38:1278-1281.

    PubMed  CAS  Google Scholar 

  19. Kark JD, Sandholzer C, Friedlander Y, Utermann G. Plasma Lp(a), apolipoprotein(a) isoforms and acute myocardial infarction in men and women: a case-control study in the Jerusalem population. Atherosclerosis. 1993;98(2):139-151.

    PubMed  CAS  Google Scholar 

  20. Srinivas VS, Garg S, Negassa A, Bang JY, Monrad ES. Persistent sex difference in hospital outcome following percutaneous coronary intervention: results from the New York State reporting system. J Invasive Cardiol. 2007;19(6):265-268.

    PubMed  CAS  Google Scholar 

  21. Sozzi FB, Danzi GB, Foco L, et al. Myocardial infarction in the young: a sex-based comparison. Coron Artery Dis. 2007;18(6):429-431.

    PubMed  Google Scholar 

  22. Burke AP, Farb A, Malcom GT, Liang Y, Smialek J, Virmani R. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998;97(21):2110-2116.

    PubMed  CAS  Google Scholar 

  23. Bugiardini R, Bairey Merz CN. Angina with “normal” coronary arteries: a changing philosophy. JAMA. 2005;293(4):477-484.

    PubMed  CAS  Google Scholar 

  24. Cavasin MA, Tao ZY, Yu AL, Yang XP. Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function. Am J Physiol Heart Circ Physiol. 2006;290(5):H2043-H2050.

    PubMed  CAS  Google Scholar 

  25. Fang L, Gao XM, Moore XL, et al. Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J Mol Cell Cardiol. 2007;43(5):535-544.

    PubMed  CAS  Google Scholar 

  26. Lee TM, Su SF, Tsai CC, Lee YT, Tsai CH. Cardioprotective effects of 17 beta-estradiol produced by activation of mitochondrial ATP-sensitive K(+)channels in canine hearts. J Mol Cell Cardiol. 2000;32(7):1147-1158.

    PubMed  CAS  Google Scholar 

  27. Lawrence JB, Leifer DW, Moura GL, et al. Sex differences in platelet adherence to subendothelium: relationship to platelet function tests and hematologic variables. Am J Med Sci. 1995;309(4):201-207.

    PubMed  CAS  Google Scholar 

  28. Kojima S, Funahashi T, Otsuka F, et al. Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction. Atherosclerosis. 2007;194(1):204-213.

    PubMed  CAS  Google Scholar 

  29. Airaksinen KE, Ikaheimo MJ, Linnaluoto M, Tahvanainen KU, Huikuri HV. Gender difference in autonomic and hemodynamic reactions to abrupt coronary occlusion. J Am Coll Cardiol. 1998;31(2):301-306.

    PubMed  CAS  Google Scholar 

  30. Chen W, Woods SL, Puntillo KA. Gender differences in symptoms associated with acute myocardial infarction: a review of the research. Heart Lung. 2005;34(4):240-247.

    PubMed  Google Scholar 

  31. Goldberg RJ, O’Donnell C, Yarzebski J, Bigelow C, Savageau J, Gore JM. Sex differences in symptom presentation associated with acute myocardial infarction: a population-based perspective. Am Heart J. 1998;136(2):189-195.

    PubMed  CAS  Google Scholar 

  32. Omran S, Al-Hassan M. Gender differences in signs and symptoms presentation and treatment of Jordanian myocardial infarction patients. Int J Nurs Pract. 2006;12(4):198-204.

    PubMed  Google Scholar 

  33. Fang J, Alderman MH. Gender differences of revascularization in patients with acute myocardial infarction. Am J Cardiol. 2006;97(12):1722-1726.

    PubMed  Google Scholar 

  34. Jneid H, Fonarow GC, Cannon CP, et al. Sex differences in medical care and early death after acute myocardial infarction. Circulation. 2008;118(25):2803-2810.

    PubMed  Google Scholar 

  35. Jani SM, Montoye C, Mehta R, et al. Sex differences in the application of evidence-based therapies for the treatment of acute myocardial infarction: the American College of Cardiology’s Guidelines Applied in Practice projects in Michigan. Arch Intern Med. 2006;166(11):1164-1170.

    PubMed  Google Scholar 

  36. Chandra NC, Ziegelstein RC, Rogers WJ, et al. Observations of the treatment of women in the United States with myocardial infarction: a report from the National Registry of Myocardial Infarction-I. Arch Intern Med. 1998;158(9):981-988.

    PubMed  CAS  Google Scholar 

  37. Milcent C, Dormont B, Durand-Zaleski I, Steg PG. Gender differences in hospital mortality and use of percutaneous coronary intervention in acute myocardial infarction: microsimulation analysis of the 1999 nationwide French hospitals database. Circulation. 2007;115(7):833-839.

    PubMed  Google Scholar 

  38. Alfredsson J, Stenestrand U, Wallentin L, Swahn E. Gender differences in management and outcome in non-ST-elevation acute coronary syndrome. Heart. 2007;93(11):1357-1362.

    PubMed  Google Scholar 

  39. Vaccarino V, Rathore SS, Wenger NK, et al. Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002. N Engl J Med. 2005;353(7):671-682.

    PubMed  CAS  Google Scholar 

  40. Wong CC, Froelicher ES, Bacchetti P, et al. Influence of gender on cardiovascular mortality in acute myocardial infarction patients with high indication for coronary angiography. Circulation. 1997;96(9 Suppl):II-51-II-57.

    Google Scholar 

  41. Demirovic J, Blackburn H, McGovern PG, Luepker R, Sprafka JM, Gilbertson D. Sex differences in early mortality after acute myocardial infarction (the Minnesota Heart Survey). Am J Cardiol. 1995;75(16):1096-1101.

    PubMed  CAS  Google Scholar 

  42. Kostis JB, Wilson AC, O’Dowd K, et al. Sex differences in the management and long-term outcome of acute myocardial infarction A statewide study. MIDAS Study Group. Myocardial Infarction Data Acquisition System. Circulation. 1994;90(4):1715-1730.

    PubMed  CAS  Google Scholar 

  43. Alexander KP, Chen AY, Newby LK, et al. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. Circulation. 2006;114(13):1380-1387.

    PubMed  CAS  Google Scholar 

  44. Vaccarino V, Abramson JL, Veledar E, Weintraub WS. Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women. Circulation. 2002;105(10):1176-1181.

    PubMed  Google Scholar 

  45. Rathore SS, Chen J, Wang Y, Radford MJ, Vaccarino V, Krumholz HM. Sex differences in cardiac catheterization: the role of physician gender. JAMA. 2001;286(22):2849-2856.

    PubMed  CAS  Google Scholar 

  46. Pagley PR, Yarzebski J, Goldberg R, et al. Gender differences in the treatment of patients with acute myocardial infarction. A multihospital, community-based perspective. Arch Intern Med. 1993;153(5):625-629.

    PubMed  CAS  Google Scholar 

  47. Maynard C, Beshansky JR, Griffith JL, Selker HP. Influence of sex on the use of cardiac procedures in patients presenting to the emergency department. A prospective multicenter study. Circulation. 1996;94(9 Suppl):II93-II98.

    PubMed  CAS  Google Scholar 

  48. DeWilde S, Carey IM, Richards N, Whincup PH, Cook DG. Trends in secondary prevention of ischaemic heart disease in the UK 1994 2005: use of individual and combination treatment. Heart. 2008;94(1):83-88.

    PubMed  CAS  Google Scholar 

  49. Mehilli J, Kastrati A, Dirschinger J, et al. Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention. JAMA. 2002;287(2):210-215.

    PubMed  Google Scholar 

  50. Bell MR, Grill DE, Garratt KN, Berger PB, Gersh BJ, Holmes DR Jr. Long-term outcome of women compared with men after successful coronary angioplasty. Circulation. 1995;91(12):2876-2881.

    PubMed  CAS  Google Scholar 

  51. Mehilli J, Kastrati A, Dirschinger J, Bollwein H, Neumann FJ, Schomig A. Differences in prognostic factors and outcomes between women and men undergoing coronary artery stenting. JAMA. 2000;284(14):1799-1805.

    PubMed  CAS  Google Scholar 

  52. Jacobs AK, Johnston JM, Haviland A, et al. Improved outcomes for women undergoing contemporary percutaneous coronary intervention: a report from the National Heart, Lung, and Blood Institute Dynamic registry. J Am Coll Cardiol. 2002;39(10):1608-1614.

    PubMed  Google Scholar 

  53. Curtis LH, Al-Khatib SM, Shea AM, Hammill BG, Hernandez AF, Schulman KA. Sex differences in the use of implantable cardioverter-defibrillators for primary and secondary prevention of sudden cardiac death. JAMA. 2007; 298(13):1517-1524.

    PubMed  CAS  Google Scholar 

  54. Regitz-Zagrosek V, Lehmkuhl E, Hocher B, et al. Gender as a risk factor in young, not in old, women undergoing coronary artery bypass grafting. J Am Coll Cardiol. 2004;44(12):2413-2414.

    PubMed  Google Scholar 

  55. Lagerqvist B, Safstrom K, Stahle E, Wallentin L, Swahn E. Is early invasive treatment of unstable coronary artery disease equally effective for both women and men? FRISC II Study Group Investigators. J Am Coll Cardiol. 2001;38(1):41-48.

    PubMed  CAS  Google Scholar 

  56. Tillmanns H, Waas W, Voss R, et al. Gender differences in the outcome of cardiac interventions. Herz. 2005;30(5):375-389.

    PubMed  Google Scholar 

  57. Safstrom K, Lindahl B, Swahn E. Risk stratification in unstable coronary artery disease–exercise test and troponin T from a gender perspective. FRISC-Study Group. Fragmin during InStability in Coronary artery disease. J Am Coll Cardiol. 2000;35(7):1791-1800.

    PubMed  CAS  Google Scholar 

  58. Moriel M, Behar S, Tzivoni D, Hod H, Boyko V, Gottlieb S. Management and outcomes of elderly women and men with acute coronary syndromes in 2000 and 2002. Arch Intern Med. 2005;165(13):1521-1526.

    PubMed  Google Scholar 

  59. Vega DD, Dolan KL, Pollack ML. Beta-blocker use in elderly ED patients with acute myocardial infarction. Am J Emerg Med. 2006;24(4):435-439.

    PubMed  Google Scholar 

  60. Putnam W, Burge FI, Lawson B, et al. Evidence-based cardiovascular care in the community: a population-based cross-sectional study. BMC Fam Pract. 2004;5:6.

    PubMed  Google Scholar 

  61. Bengtson A, Karlsson T, Herlitz J. Differences between men and women on the waiting list for coronary revascularization. J Adv Nurs. 2000;31(6):1361-1367.

    PubMed  CAS  Google Scholar 

  62. Mahon NG, McKenna CJ, Codd MB, O’Rorke C, McCann HA, Sugrue DD. Gender differences in the management and outcome of acute myocardial infarction in unselected patients in the thrombolytic era. Am J Cardiol. 2000;85(8):921-926.

    PubMed  CAS  Google Scholar 

  63. Boersma E, Harrington RA, Moliterno DJ, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet. 2002;359(9302):189-198.

    PubMed  CAS  Google Scholar 

  64. Lansky AJ, Pietras C, Costa RA, et al. Gender differences in outcomes after primary angioplasty versus primary stenting with and without abciximab for acute myocardial infarction: results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial. Circulation. 2005;111(13):1611-1618.

    PubMed  CAS  Google Scholar 

  65. Cho L, Topol EJ, Balog C, et al. Clinical benefit of glycoprotein IIb/IIIa blockade with abciximab is independent of gender: pooled analysis from EPIC, EPILOG and EPISTENT trials. Evaluation of 7E3 for the prevention of ischemic complications. Evaluation in percutaneous transluminal coronary angioplasty to improve long-term outcome with abciximab GP IIb/IIIa blockade. Evaluation of platelet IIb/IIIa inhibitor for stent. J Am Coll Cardiol. 2000;36(2):381-386.

    PubMed  CAS  Google Scholar 

  66. Regitz-Zagrosek V, Schubert C, Kruger S. Sex differences in cardiovascular drug targeting. Internist (Berl). 2008;49(11): 1383-1386. 1388-1390.

    CAS  Google Scholar 

  67. European Secondary Prevention Study Group. Translation of clinical trials into practice: a European population-based study of the use of thrombolysis for acute myocardial infarction. Lancet. 1996;347(9010):1203-1207.

    Google Scholar 

  68. Rochon PA, Clark JP, Binns MA, Patel V, Gurwitz JH. Reporting of gender-related information in clinical trials of drug therapy for myocardial infarction. CMAJ. 1998;159(4):321-327.

    PubMed  CAS  Google Scholar 

  69. Bonarjee VV, Rosengren A, Snapinn SM, James MK, Dickstein K. Sex-based short- and long-term survival in patients following complicated myocardial infarction. Eur Heart J. 2006;27(18):2177-2183.

    PubMed  Google Scholar 

  70. Heer T, Schiele R, Schneider S, et al. Gender differences in acute myocardial infarction in the era of reperfusion (the MITRA registry). Am J Cardiol. 2002;89(5):511-517.

    PubMed  Google Scholar 

  71. Vakili BA, Kaplan RC, Brown DL. Sex-based differences in early mortality of patients undergoing primary angioplasty for first acute myocardial infarction. Circulation. 2001;104(25):3034-3038.

    PubMed  CAS  Google Scholar 

  72. Marrugat J, Garcia M, Elosua R, et al. Short-term (28 days) prognosis between genders according to the type of coronary event (Q-wave versus non-Q-wave acute myocardial infarction versus unstable angina pectoris). Am J Cardiol. 2004;94(9):1161-1165.

    PubMed  Google Scholar 

  73. Wong SC, Sleeper LA, Monrad ES, et al. Absence of gender differences in clinical outcomes in patients with cardiogenic shock complicating acute myocardial infarction. A report from the SHOCK Trial Registry. J Am Coll Cardiol. 2001;38(5):1395-1401.

    PubMed  CAS  Google Scholar 

  74. Coronado BE, Griffith JL, Beshansky JR, Selker HP. Hospital mortality in women and men with acute cardiac ischemia: a prospective multicenter study. J Am Coll Cardiol. 1997;29(7):1490-1496.

    PubMed  CAS  Google Scholar 

  75. Koek HL, de Bruin A, Gast F, et al. Short- and long-term prognosis after acute myocardial infarction in men versus women. Am J Cardiol. 2006;98(8):993-999.

    PubMed  Google Scholar 

  76. Bowker TJ, Turner RM, Wood DA, et al. A national Survey of Acute Myocardial Infarction and Ischaemia (SAMII) in the U.K.: characteristics, management and in-hospital outcome in women compared to men in patients under 70 years. Eur Heart J. 2000;21(17):1458-1463.

    PubMed  CAS  Google Scholar 

  77. Vaccarino V, Horwitz RI, Meehan TP, Petrillo MK, Radford MJ, Krumholz HM. Sex differences in mortality after myocardial infarction: evidence for a sex-age interaction. Arch Intern Med. 1998;158(18):2054-2062.

    PubMed  CAS  Google Scholar 

  78. Herman B, Greiser E, Pohlabeln H. A sex difference in short-term survival after initial acute myocardial infarction. The MONICA-Bremen Acute Myocardial Infarction Register, 1985-1990. Eur Heart J. 1997;18(6):963-970.

    PubMed  CAS  Google Scholar 

  79. Vaccarino V, Krumholz HM, Yarzebski J, Gore JM, Goldberg RJ. Sex differences in 2-year mortality after hospital discharge for myocardial infarction. Ann Intern Med. 2001;134(3):173-181.

    PubMed  CAS  Google Scholar 

  80. Rosengren A, Spetz CL, Koster M, Hammar N, Alfredsson L, Rosen M. Sex differences in survival after myocardial infarction in Sweden; data from the Swedish National Acute Myocardial Infarction Register. Eur Heart J. 2001;22(4):314-322.

    PubMed  CAS  Google Scholar 

  81. Norhammar A, Stenestrand U, Lindback J, Wallentin L. Women younger than 65 years with diabetes mellitus are a high-risk group after myocardial infarction: a report from the Swedish Register of Information and Knowledge about Swedish Heart Intensive Care Admission (RIKS-HIA). Heart. 2008;94(12):1565-1570.

    PubMed  CAS  Google Scholar 

  82. Crowley A, Menon V, Lessard D, et al. Sex differences in survival after acute myocardial infarction in patients with diabetes mellitus (Worcester Heart Attack Study). Am Heart J. 2003;146(5):824-831.

    PubMed  Google Scholar 

  83. Graham MM, Ghali WA, Faris PD, Galbraith PD, Norris CM, Knudtson ML. Sex differences in the prognostic importance of diabetes in patients with ischemic heart disease undergoing coronary angiography. Diabetes Care. 2003; 26(11):3142-3147.

    PubMed  Google Scholar 

  84. Goldberg RJ, Gorak EJ, Yarzebski J, et al. A communitywide perspective of sex differences and temporal trends in the incidence and survival rates after acute myocardial infarction and out-of-hospital deaths caused by coronary heart disease. Circulation. 1993;87(6):1947-1953.

    PubMed  CAS  Google Scholar 

  85. Tunstall-Pedoe H, Morrison C, Woodward M, Fitzpatrick B, Watt G. Sex differences in myocardial infarction and coronary deaths in the Scottish MONICA population of Glasgow 1985 to 1991. Presentation, diagnosis, treatment, and 28-day case fatality of 3991 events in men and 1551 events in women. Circulation. 1996;93(11):1981-1992.

    PubMed  CAS  Google Scholar 

  86. Gottlieb S, Harpaz D, Shotan A, et al. Sex differences in management and outcome after acute myocardial infarction in the 1990s: a prospective observational community-based study. Israeli Thrombolytic Survey Group. Circulation. 2000;102(20):2484-2490.

    PubMed  CAS  Google Scholar 

  87. Mak KH, Kark JD, Chia KS, et al. Ethnic variations in female vulnerability after an acute coronary event. Heart. 2004;90(6):621-626.

    PubMed  CAS  Google Scholar 

  88. Lundblad D, Holmgren L, Jansson JH, Naslund U, Eliasson M. Gender differences in trends of acute myocardial infarction events: the Northern Sweden MONICA study 1985–2004. BMC Cardiovasc Disord. 2008;8:17.

    PubMed  Google Scholar 

  89. Chien KL, Lee WC, Sung FC, Lin RS, Lee YT. Sex difference in the mortality trends of acute myocardial infarction in Taiwan, 1974 to 1993. J Formos Med Assoc. 1998;97(5):309-314.

    PubMed  CAS  Google Scholar 

  90. Heikkila J, Paunonen M, Virtanen V, Laippala P. Gender differences in fears related to coronary arteriography. Heart Lung. 1999;28(1):20-30.

    PubMed  CAS  Google Scholar 

  91. Riegel B, Gocka I. Gender differences in adjustment to acute myocardial infarction. Heart Lung. 1995;24(6):457-466.

    PubMed  CAS  Google Scholar 

  92. Grande G, Leppin A, Romppel M, Altenhoner T, Mannebach H. Women and men after acute myocardial infarction: are there gender differences in participation rates in cardiac rehabilitation? Rehabilitation (Stuttg). 2002;41(5):320-328.

    CAS  Google Scholar 

  93. Norris CM, Hegadoren K, Pilote L. Depression symptoms have a greater impact on the 1-year health-related quality of life outcomes of women post-myocardial infarction compared to men. Eur J Cardiovasc Nurs. 2007;6(2):92-98.

    PubMed  Google Scholar 

  94. Kim KA, Moser DK, Garvin BJ, et al. Differences between men and women in anxiety early after acute myocardial infarction. Am J Crit Care. 2000;9(4):245-253.

    PubMed  CAS  Google Scholar 

  95. Garavalia LS DC, Reid KJ, Lichtman JH, et al. Does health status differ between men and women in early recovery after myocardial infarction? J Womens Health (Larchmt). 2007;16(1):93-101.

    Google Scholar 

  96. Agewall S, Berglund M, Henareh L. Reduced quality of life after myocardial infarction in women compared with men. Clin Cardiol. 2004;27(5):271-274.

    PubMed  Google Scholar 

  97. Frasure-Smith N, Lesperance F, Juneau M, Talajic M, Bourassa MG. Gender, depression, and one-year prognosis after myocardial infarction. Psychosom Med. 1999;61(1):26-37.

    PubMed  CAS  Google Scholar 

  98. Lloyd CE, Kuller LH, Ellis D, Becker DJ, Wing RR, Orchard TJ. Coronary artery disease in IDDM. Gender differences in risk factors but not risk. Arterioscler Thromb Vasc Biol. 1996;16(6):720-726.

    PubMed  CAS  Google Scholar 

  99. Pajunen P, Taskinen MR, Nieminen MS, Syvanne M. Angiographic severity and extent of coronary artery disease in patients with type 1 diabetes mellitus. Am J Cardiol. 2000;86(10):1080-1085.

    PubMed  CAS  Google Scholar 

  100. Han SH, Bae JH, Holmes DR Jr, et al. Sex differences in atheroma burden and endothelial function in patients with early coronary atherosclerosis. Eur Heart J. 2008; 29(11):1359-1369.

    PubMed  Google Scholar 

  101. Kyriakidis M, Petropoulakis P, Androulakis A, et al. Sex differences in the anatomy of coronary artery disease. J Clin Epidemiol. 1995;48(6):723-730.

    PubMed  CAS  Google Scholar 

  102. von Mering GO, Arant CB, Wessel TR, et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE). Circulation. 2004;109(6):722-725.

    Google Scholar 

  103. Johnson BD, Shaw LJ, Buchthal SD, et al. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE). Circulation. 2004;109(24):2993-2999.

    PubMed  Google Scholar 

  104. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005; 18(12):1440-1463.

    PubMed  Google Scholar 

  105. Buchthal SD, den Hollander JA, Merz CN, et al. Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms. N Engl J Med. 2000;342(12):829-835.

    PubMed  CAS  Google Scholar 

  106. Zenovich AG, Panoskaltsis-Mortari A, Caron GJ, et al. Sex-based differences in vascular repair with bone marrow cell therapy: relevance of regulatory and Th2-type cytokines. Transplant Proc. 2008;40(2):641-643.

    PubMed  CAS  Google Scholar 

  107. Nelson WD, Zenovich AG, Ott HC, et al. Sex-dependent attenuation of plaque growth after treatment with bone marrow mononuclear cells. Circ Res. 2007;101(12):1319-1327.

    PubMed  CAS  Google Scholar 

  108. Sudhir K, Komesaroff PA. Clinical review 110: cardiovascular actions of estrogens in men. J Clin Endocrinol Metab. 1999;84(10):3411-3415.

    PubMed  CAS  Google Scholar 

  109. Linden T, Taddei-Peters W, Wilhelmsen L, et al. Serum lipids, lipoprotein(a) and apo(a) isoforms in patients with established coronary artery disease and their relation to disease and prognosis after coronary by-pass surgery. Atherosclerosis. 1998;137(1):175-186.

    PubMed  CAS  Google Scholar 

  110. Ossei-Gerning N, Wilson IJ, Grant PJ. Sex differences in coagulation and fibrinolysis in subjects with coronary artery disease. Thromb Haemost. 1998;79(4):736-740.

    PubMed  CAS  Google Scholar 

  111. Duvernoy CS, Meyer C, Seifert-Klauss V, et al. Gender differences in myocardial blood flow dynamics: lipid profile and hemodynamic effects. J Am Coll Cardiol. 1999; 33(2):463-470.

    PubMed  CAS  Google Scholar 

  112. Dey S, Flather MD, Devlin G, et al. Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events. Heart. 2009;95(1):20-26.

    PubMed  CAS  Google Scholar 

  113. Kruk M, Pregowski J, Mintz GS, et al. Intravascular ultrasonic study of gender differences in ruptured coronary plaque morphology and its associated clinical presentation. Am J Cardiol. 2007;100(2):185-189.

    PubMed  Google Scholar 

  114. Kasai T, Miyauchi K, Kubota N, et al. The relationship between the metabolic syndrome defined by various criteria and the extent of coronary artery disease. Atherosclerosis. 2008;197(2):944-950.

    PubMed  CAS  Google Scholar 

  115. Daly C, Clemens F, Lopez Sendon JL, et al. Gender differences in the management and clinical outcome of stable angina. Circulation. 2006;113(4):490-498.

    PubMed  Google Scholar 

  116. Sheifer SE, Escarce JJ, Schulman KA. Race and sex differences in the management of coronary artery disease. Am Heart J. 2000;139(5):848-857.

    PubMed  CAS  Google Scholar 

  117. Roger VL, Jacobsen SJ, Weston SA, et al. Sex differences in evaluation and outcome after stress testing. Mayo Clin Proc. 2002;77(7):638-645.

    PubMed  Google Scholar 

  118. Mieres JH, Shaw LJ, Arai A, et al. Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease: consensus statement from the Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Circulation. 2005;111(5):682-696.

    PubMed  Google Scholar 

  119. Biagini E, Elhendy A, Bax JJ, et al. Seven-year follow-up after dobutamine stress echocardiography: impact of gender on prognosis. J Am Coll Cardiol. 2005;45(1):93-97.

    PubMed  Google Scholar 

  120. Arruda-Olson AM, Juracan EM, Mahoney DW, McCully RB, Roger VL, Pellikka PA. Prognostic value of exercise echocardiography in 5,798 patients: is there a gender difference? J Am Coll Cardiol. 2002;39(4):625-631.

    PubMed  Google Scholar 

  121. Shaw LJ, Merz CN, Pepine CJ, et al. The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health – National Heart, Lung, and Blood Institute – sponsored Women’s Ischemia Syndrome Evaluation. Circulation. 2006;114(9): 894-904.

    PubMed  Google Scholar 

  122. Grodstein F, Stampfer MJ, Manson JE, et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med. 1996;335(7):453-461.

    PubMed  CAS  Google Scholar 

  123. Harman SM, Brinton EA, Naftolin F, et al. Menopausal hormone therapy and risk for cardiovascular disease in the WHI trial. Ann Intern Med. 2010;153(1):60-61. author reply 61-62.

    PubMed  Google Scholar 

  124. Shaw LJ, Miller DD, Romeis JC, Kargl D, Younis LT, Chaitman BR. Gender differences in the noninvasive evaluation and management of patients with suspected coronary artery disease. Ann Intern Med. 1994;120(7): 559-566.

    PubMed  CAS  Google Scholar 

  125. Steingart RM, Packer M, Hamm P, et al. Sex differences in the management of coronary artery disease. Survival and Ventricular Enlargement Investigators. N Engl J Med. 1991;325(4):226-230.

    PubMed  CAS  Google Scholar 

  126. Enriquez JR, Pratap P, Zbilut JP, Calvin JE, Volgman AS. Women tolerate drug therapy for coronary artery disease as well as men do, but are treated less frequently with aspirin, beta-blockers, or statins. Gend Med. 2008;5(1):53-61.

    PubMed  Google Scholar 

  127. Shaw LJ, Bugiardini R, Merz CN. Women and ischemic heart disease: evolving knowledge. J Am Coll Cardiol. 2009;54(17):1561-1575.

    PubMed  Google Scholar 

  128. Abbott JD, Vlachos HA, Selzer F, et al. Gender-based outcomes in percutaneous coronary intervention with drug-eluting stents (from the National Heart, Lung, and Blood Institute Dynamic Registry). Am J Cardiol. 2007;99(5):626-631.

    PubMed  CAS  Google Scholar 

  129. Singh M, Rihal CS, Gersh BJ, et al. Mortality differences between men and women after percutaneous coronary interventions. A 25-year, single-center experience. J Am Coll Cardiol. 2008;51(24):2313-2320.

    PubMed  Google Scholar 

  130. Glaser R, Herrmann HC, Murphy SA, et al. Benefit of an early invasive management strategy in women with acute coronary syndromes. JAMA. 2002;288(24):3124-3129.

    PubMed  Google Scholar 

  131. Shaw LJ, Shaw RE, Merz CN, et al. Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data Registry. Circulation. 2008;117(14):1787-1801.

    PubMed  Google Scholar 

  132. Bassand JP, Hamm CW, Ardissino D, et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J. 2007;28(13):1598-1660.

    PubMed  CAS  Google Scholar 

  133. Kannel WB, Wolf PA, Benjamin EJ, Levy D. Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol. 1998;82(8A):2N-9N.

    PubMed  CAS  Google Scholar 

  134. Lampert R, McPherson CA, Clancy JF, Caulin-Glaser TL, Rosenfeld LE, Batsford WP. Gender differences in ventricular arrhythmia recurrence in patients with coronary artery disease and implantable cardioverter-defibrillators. J Am Coll Cardiol. 2004;43(12):2293-2299.

    PubMed  Google Scholar 

  135. Ruixing Y, Jinzhen W, Shangling P, Weixiong L, Dezhai Y, Yuming C. Sex differences in environmental and genetic factors for hypertension. Am J Med. 2008;121(9):811-819.

    PubMed  Google Scholar 

  136. Thijs L, Dabrowska E, Clement D, et al. Diurnal blood pressure profile in older patients with isolated systolic hypertension. The SYST-EUR Investigators. J Hum Hypertens. 1995;9(11):917-924.

    PubMed  CAS  Google Scholar 

  137. Agyemang C, de Munter J, van Valkengoed I, van den Born BJ, Stronks K. Gender disparities in hypertension among different ethnic groups in Amsterdam, the Netherlands: the SUNSET study. Am J Hypertens. 2008;21(9):1001-1006.

    PubMed  Google Scholar 

  138. Wang W, Lee ET, Fabsitz RR, et al. A longitudinal study of hypertension risk factors and their relation to cardiovascular disease: the Strong Heart Study. Hypertension. 2006;47(3):403-409.

    PubMed  CAS  Google Scholar 

  139. Wang X, Poole JC, Treiber FA, Harshfield GA, Hanevold CD, Snieder H. Ethnic and gender differences in ambulatory blood pressure trajectories: results from a 15-year longitudinal study in youth and young adults. Circulation. 2006;114(25):2780-2787.

    PubMed  Google Scholar 

  140. Port S, Demer L, Jennrich R, Walter D, Garfinkel A. Systolic blood pressure and mortality. Lancet. 2000; 355(9199):175-180.

    PubMed  CAS  Google Scholar 

  141. Antonicelli R, Gesuita R, Paciaroni E. Sexual dimorphism in arterial hypertension: an age-related phenomenon. Arch Gerontol Geriatr. 1999;29(3):283-289.

    PubMed  CAS  Google Scholar 

  142. Greenlund KJ, Croft JB, Mensah GA. Prevalence of heart disease and stroke risk factors in persons with prehypertension in the United States, 1999-2000. Arch Intern Med. 2004;164(19):2113-2118.

    PubMed  Google Scholar 

  143. Ong KL, Tso AW, Lam KS, Cheung BM. Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension. Hypertension. 2008;51(4):1142-1148.

    PubMed  CAS  Google Scholar 

  144. Vuagnat A, Giacche M, Hopkins PN, et al. Blood pressure response to angiotensin II, low-density lipoprotein cholesterol and polymorphisms of the angiotensin II type 1 receptor gene in hypertensive sibling pairs. J Mol Med. 2001;79(4):175-183.

    PubMed  CAS  Google Scholar 

  145. Donahue RP, Rejman K, Rafalson LB, Dmochowski J, Stranges S, Trevisan M. Sex differences in endothelial function markers before conversion to pre-diabetes: does the clock start ticking earlier among women? The Western New York Study. Diabetes Care. 2007;30(2):354-359.

    PubMed  Google Scholar 

  146. Carlsson AC, Wandell PE, de Faire U, Hellenius ML. Risk factors associated with newly diagnosed high blood pressure in men and women. Am J Hypertens. 2008;21(7):771-777.

    PubMed  Google Scholar 

  147. Goldstein IB, Shapiro D, Guthrie D. Ambulatory blood pressure and family history of hypertension in healthy men and women. Am J Hypertens. 2006;19(5):486-491.

    PubMed  Google Scholar 

  148. Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK. The progression from hypertension to congestive heart failure. JAMA. 1996;275(20):1557-1562.

    PubMed  CAS  Google Scholar 

  149. Levenstein S, Smith MW, Kaplan GA. Psychosocial predictors of hypertension in men and women. Arch Intern Med. 2001;161(10):1341-1346.

    PubMed  CAS  Google Scholar 

  150. Mohsenin V, Yaggi HK, Shah N, Dziura J. The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Med. 2009;10(7):759-762.

    PubMed  Google Scholar 

  151. Rexhepaj R, Boini KM, Huang DY, et al. Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet. Am J Physiol Regul Integr Comp Physiol. 2008;294(6): R2008-R2013.

    PubMed  CAS  Google Scholar 

  152. Lipsitz LA, Iloputaife I, Gagnon M, Kiely DK, Serrador JM. Enhanced vasoreactivity and its response to antihypertensive therapy in hypertensive elderly women. Hypertension. 2006;47(3):377-383.

    PubMed  CAS  Google Scholar 

  153. Park S, Ha JW, Shim CY, et al. Gender-related difference in arterial elastance during exercise in patients with hypertension. Hypertension. 2008;51(4):1163-1169.

    PubMed  CAS  Google Scholar 

  154. Ahimastos AA, Formosa M, Dart AM, Kingwell BA. Gender differences in large artery stiffness pre- and post puberty. J Clin Endocrinol Metab. 2003;88(11):5375-5380.

    PubMed  CAS  Google Scholar 

  155. Reckelhoff JF, Zhang H, Srivastava K, Granger JP. Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor. Hypertension. 1999;34(4 Pt 2):920-923.

    PubMed  CAS  Google Scholar 

  156. Singh H, Cheng J, Deng H, et al. Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension. Hypertension. 2007;50(1):123-129.

    PubMed  CAS  Google Scholar 

  157. Stallone JN. Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats. Am J Physiol. 1995;268(1 Pt 2):R40-R49.

    PubMed  CAS  Google Scholar 

  158. Sullivan JC, Sasser JM, Pollock DM, Pollock JS. Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats. Hypertension. 2005;45(3):406-411.

    PubMed  CAS  Google Scholar 

  159. Laurent P, Albaladejo P, Blacher J, Rudnichi A, Smulyan H, Safar ME. Heart rate and pulse pressure amplification in hypertensive subjects. Am J Hypertens. 2003;16(5 Pt 1): 363-370.

    PubMed  Google Scholar 

  160. Song D, Arikawa E, Galipeau DM, et al. Chronic estrogen treatment modifies insulin-induced insulin resistance and hypertension in ovariectomized rats. Am J Hypertens. 2005;18(9 Pt 1):1189-1194.

    PubMed  CAS  Google Scholar 

  161. David FL, Carvalho MH, Cobra AL, et al. Ovarian hormones modulate endothelin-1 vascular reactivity and mRNA expression in DOCA-salt hypertensive rats. Hypertension. 2001;38(3 Pt 2):692-696.

    PubMed  CAS  Google Scholar 

  162. Nakano D, Pollock DM. Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats. Hypertension. 2009;53(2):324-330.

    PubMed  CAS  Google Scholar 

  163. Sullivan JC, Sasser JM, Pollock JS. Sexual dimorphism in oxidant status in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2007;292(2): R764-R768.

    PubMed  CAS  Google Scholar 

  164. Kahonen M, Tolvanen JP, Sallinen K, Wu X, Porsti I. Influence of gender on control of arterial tone in experimental hypertension. Am J Physiol. 1998;275(1 Pt 2):H15-H22.

    PubMed  CAS  Google Scholar 

  165. Ji H, Menini S, Mok K, et al. Gonadal steroid regulation of renal injury in renal wrap hypertension. Am J Physiol Renal Physiol. 2005;288(3):F513-F520.

    PubMed  CAS  Google Scholar 

  166. Ji H, Pesce C, Zheng W, et al. Sex differences in renal injury and nitric oxide production in renal wrap hypertension. Am J Physiol Heart Circ Physiol. 2005;288(1):H43-H47.

    PubMed  CAS  Google Scholar 

  167. Reckelhoff JF, Zhang H, Srivastava K. Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system. Hypertension. 2000;35(1 Pt 2):480-483.

    PubMed  CAS  Google Scholar 

  168. Veniant M, Menard J, Bruneval P, Morley S, Gonzales MF, Mullins J. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest. 1996;98(9):1966-1970.

    PubMed  CAS  Google Scholar 

  169. Yanes LL, Romero DG, Iles JW, Iliescu R, Gomez-Sanchez C, Reckelhoff JF. Sexual dimorphism in the renin-angiotensin system in aging spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2006;291(2): R383-R390.

    PubMed  CAS  Google Scholar 

  170. Chen YF, Naftilan AJ, Oparil S. Androgen-dependent angiotensinogen and renin messenger RNA expression in hypertensive rats. Hypertension. 1992;19(5):456-463.

    PubMed  CAS  Google Scholar 

  171. Wang G, Milner TA, Speth RC, et al. Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol. 2008;295(4):R1149-R1157.

    PubMed  CAS  Google Scholar 

  172. Girouard H, Lessard A, Capone C, Milner TA, Iadecola C. The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic. Am J Physiol Heart Circ Physiol. 2008;294(1):H156-H163.

    PubMed  CAS  Google Scholar 

  173. Lopez-Ruiz A, Sartori-Valinotti J, Yanes LL, Iliescu R, Reckelhoff JF. Sex differences in control of blood pressure: role of oxidative stress in hypertension in females. Am J Physiol Heart Circ Physiol. 2008;295(2):H466-H474.

    PubMed  CAS  Google Scholar 

  174. Wang X, Desai K, Juurlink BH, de Champlain J, Wu L. Gender-related differences in advanced glycation endproducts, oxidative stress markers and nitric oxide synthases in rats. Kidney Int. 2006;69(2):281-287.

    PubMed  CAS  Google Scholar 

  175. Levy D, Kenchaiah S, Larson MG, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18):1397-1402.

    PubMed  Google Scholar 

  176. Sherwood A, May CW, Siegel WC, Blumenthal JA. Ethnic differences in hemodynamic responses to stress in hypertensive men and women. Am J Hypertens. 1995;8(6):552-557.

    PubMed  CAS  Google Scholar 

  177. Myers MG, Reeves RA. White coat effect in treated hypertensive patients: sex differences. J Hum Hypertens. 1995;9(9):729-733.

    PubMed  CAS  Google Scholar 

  178. MacDonald MB, Laing GP, Wilson MP, Wilson TW. Prevalence and predictors of white-coat response in patients with treated hypertension. CMAJ. 1999;161(3):265-269.

    PubMed  CAS  Google Scholar 

  179. Krumholz HM, Larson M, Levy D. Sex differences in cardiac adaptation to isolated systolic hypertension. Am J Cardiol. 1993;72(3):310-313.

    PubMed  CAS  Google Scholar 

  180. Vriz O, Lu H, Visentin P, Nicolosi L, Mos L, Palatini P. Gender differences in the relationship between left ventricular size and ambulatory blood pressure in borderline hypertension. The HARVEST study. Eur Heart J. 1997; 18(4):664-670.

    PubMed  CAS  Google Scholar 

  181. Gerdts E, Zabalgoitia M, Bjornstad H, Svendsen TL, Devereux RB. Gender differences in systolic left ventricular function in hypertensive patients with electrocardiographic left ventricular hypertrophy (the LIFE study). Am J Cardiol. 2001;87(8):980-983. A984.

    PubMed  CAS  Google Scholar 

  182. Gerdts E, Okin PM, de Simone G, et al. Gender differences in left ventricular structure and function during antihypertensive treatment: the Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension. 2008;51(4):1109-1114.

    PubMed  CAS  Google Scholar 

  183. Petrella RJ. How effective is exercise training for the treatment of hypertension? Clin J Sport Med. 1998;8(3):224-231.

    PubMed  CAS  Google Scholar 

  184. Gu Q, Burt VL, Paulose-Ram R, Dillon CF. Gender differences in hypertension treatment, drug utilization patterns, and blood pressure control among US adults with hypertension: data from the National Health and Nutrition Examination Survey 1999-2004. Am J Hypertens. 2008;21(7):789-798.

    PubMed  Google Scholar 

  185. Taylor SD, Bagozzi RP, Gaither CA. Gender differences in the self-regulation of hypertension. J Behav Med. 2001;24(5):469-487.

    PubMed  CAS  Google Scholar 

  186. De Backer G, Myny K, De Henauw S, et al. Prevalence, awareness, treatment and control of arterial hypertension in an elderly population in Belgium. J Hum Hypertens. 1998;12(10):701-706.

    PubMed  Google Scholar 

  187. Banegas JR, Segura J, de la Sierra A, et al. Gender differences in office and ambulatory control of hypertension. Am J Med. 2008;121(12):1078-1084.

    PubMed  Google Scholar 

  188. Ben-Dov IZ, Mekler J, Bursztyn M. Sex differences in ambulatory blood pressure monitoring. Am J Med. 2008;121(6):509-514.

    PubMed  Google Scholar 

  189. Os I, Bratland B, Dahlof B, Gisholt K, Syvertsen JO, Tretli S. Female preponderance for lisinopril-induced cough in hypertension. Am J Hypertens. 1994;7(11):1012-1015.

    PubMed  CAS  Google Scholar 

  190. Yesil S, Yesil M, Bayata S, Postaci N. ACE inhibitors and cough. Angiology. 1994;45(9):805-808.

    PubMed  CAS  Google Scholar 

  191. Hudson M, Rahme E, Behlouli H, Sheppard R, Pilote L. Sex differences in the effectiveness of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in patients with congestive heart failure – a population study. Eur J Heart Fail. 2007;9(6–7):602-609.

    PubMed  CAS  Google Scholar 

  192. Kloner RA, Sowers JR, DiBona GF, Gaffney M, Wein M. Sex- and age-related antihypertensive effects of amlodipine. The Amlodipine Cardiovascular Community Trial Study Group. Am J Cardiol. 1996;77(9):713-722.

    PubMed  CAS  Google Scholar 

  193. Kawamoto R, Tomita H, Inoue A, Ohtsuka N, Kamitani A. Metabolic syndrome may be a risk factor for early carotid atherosclerosis in women but not in men. J Atheroscler Thromb. 2007;14(1):36-43.

    PubMed  Google Scholar 

  194. Okamoto K, Horisawa R, Ohno Y. The relationships of gender, cigarette smoking, and hypertension with the risk of aneurysmal subarachnoid hemorrhage: a case-control study in Nagoya, Japan. Ann Epidemiol. 2005;15(10):744-748.

    PubMed  Google Scholar 

  195. Horio T, Miyazato J, Kamide K, Takiuchi S, Kawano Y. Influence of low high-density lipoprotein cholesterol on left ventricular hypertrophy and diastolic function in essential hypertension. Am J Hypertens. 2003;16(11 Pt 1):938-944.

    PubMed  CAS  Google Scholar 

  196. Waldstein SR, Katzel LI. Gender differences in the relation of hypertension to cognitive function in older adults. Neurol Res. 2004;26(5):502-506.

    PubMed  Google Scholar 

  197. Romundstad S, Holmen J, Hallan H, Kvenild K, Ellekjaer H. Microalbuminuria and all-cause mortality in treated hypertensive individuals: does sex matter? The Nord-Trondelag Health Study (HUNT), Norway. Circulation. 2003;108(22):2783-2789.

    PubMed  Google Scholar 

  198. Cleland JG, Swedberg K, Follath F, et al. The EuroHeart Failure survey programme – a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis. Eur Heart J. 2003;24(5):442-463.

    PubMed  CAS  Google Scholar 

  199. Regitz-Zagrosek V, Brokat S, Tschope C. Role of gender in heart failure with normal left ventricular ejection fraction. Prog Cardiovasc Dis. 2007;49(4):241-251.

    PubMed  CAS  Google Scholar 

  200. Lenzen MJ, Rosengren A, op Reimer WJ Scholte, et al. Management of patients with heart failure in clinical practice: differences between men and women. Heart. 2008;94(3):e10.

    PubMed  CAS  Google Scholar 

  201. Deswal A, Bozkurt B. Comparison of morbidity in women versus men with heart failure and preserved ejection fraction. Am J Cardiol. 2006;97(8):1228-1231.

    PubMed  Google Scholar 

  202. Nieminen MS, Harjola VP, Hochadel M, et al. Gender related differences in patients presenting with acute heart failure. Results from EuroHeart Failure Survey II. Eur J Heart Fail. 2008;10(2):140-148.

    PubMed  Google Scholar 

  203. Burstein JM, Yan R, Weller I, Abramson BL. Management of congestive heart failure: a gender gap may still exist. Observations from a contemporary cohort. BMC Cardiovasc Disord. 2003;3:1.

    PubMed  Google Scholar 

  204. Ciana P, Raviscioni M, Mussi P, et al. In vivo imaging of transcriptionally active estrogen receptors. Nat Med. 2003;9(1):82-86.

    PubMed  CAS  Google Scholar 

  205. Mahmoodzadeh S, Eder S, Nordmeyer J, et al. Estrogen receptor alpha up-regulation and redistribution in human heart failure. FASEB J. 2006;20(7):926-934.

    PubMed  CAS  Google Scholar 

  206. Nordmeyer J, Eder S, Mahmoodzadeh S, et al. Upregulation of myocardial estrogen receptors in human aortic stenosis. Circulation. 2004;110(20):3270-3275.

    PubMed  CAS  Google Scholar 

  207. Fliegner D, Schubert C, Penkalla A, et al. Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload. Am J Physiol Regul Integr Comp Physiol. 2010;298(6):R1597-R1606.

    PubMed  CAS  Google Scholar 

  208. Petrov G, Regitz-Zagrosek V, Lehmkuhl E, et al. Regression of myocardial hypertrophy after aortic valve replacement: faster in women? Circulation. 2010;122(11 Suppl): S23-S28.

    PubMed  Google Scholar 

  209. Carroll JD, Carroll EP, Feldman T, et al. Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation. 1992;86(4):1099-1107.

    PubMed  CAS  Google Scholar 

  210. Villari B, Campbell SE, Schneider J, Vassalli G, Chiariello M, Hess OM. Sex-dependent differences in left ventricular function and structure in chronic pressure overload. Eur Heart J. 1995;16(10):1410-1419.

    PubMed  CAS  Google Scholar 

  211. Villari B, Vassalli G, Monrad ES, Chiariello M, Turina M, Hess OM. Normalization of diastolic dysfunction in aortic stenosis late after valve replacement. Circulation. 1995;91(9):2353-2358.

    PubMed  CAS  Google Scholar 

  212. Fielitz J, Hein S, Mitrovic V, et al. Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease. J Am Coll Cardiol. 2001;37(5):1443-1449.

    PubMed  CAS  Google Scholar 

  213. Fielitz J, Leuschner M, Zurbrugg HR, et al. Regulation of matrix metalloproteinases and their inhibitors in the left ventricular myocardium of patients with aortic stenosis. J Mol Med. 2004;82(12):809-820.

    PubMed  CAS  Google Scholar 

  214. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355(3):251-259.

    PubMed  CAS  Google Scholar 

  215. Regitz-Zagrosek V, Petrov G, Lehmkuhl E, et al. Heart transplantation in women with dilated cardiomyopathy. Transplantation. 2010;89(2):236-244.

    PubMed  Google Scholar 

  216. Benjamin EJ, Levy D, Vaziri SM, D’Agostino RB, Belanger AJ, Wolf PA. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA. 1994;271(11):840-844.

    PubMed  CAS  Google Scholar 

  217. Hsich E, Chadalavada S, Krishnaswamy G, et al. Long-term prognostic value of peak oxygen consumption in women versus men with heart failure and severely impaired left ventricular systolic function. Am J Cardiol. 2007;100(2):291-295.

    PubMed  CAS  Google Scholar 

  218. Fang MC, Singer DE, Chang Y, et al. Gender differences in the risk of ischemic stroke and peripheral embolism in atrial fibrillation: the AnTicoagulation and Risk factors in Atrial fibrillation (ATRIA) study. Circulation. 2005;112(12):1687-1691.

    PubMed  Google Scholar 

  219. Riedinger MS, Dracup KA, Brecht ML, Padilla G, Sarna L, Ganz PA. Quality of life in patients with heart failure: do gender differences exist? Heart Lung. 2001;30(2):105-116.

    PubMed  CAS  Google Scholar 

  220. Kendel F, Gelbrich G, Wirtz M, et al. Predictive relationship between depression and physical functioning after coronary surgery. Arch Intern Med. 2010;170(19):1717-1721.

    PubMed  Google Scholar 

  221. Agvall B, Dahlstrom U. Patients in primary health care diagnosed and treated as heart failure, with special reference to gender differences. Scand J Prim Health Care. 2001;19(1):14-19.

    PubMed  CAS  Google Scholar 

  222. Martinez-Selles M, Garcia Robles JA, Prieto L, et al. Systolic dysfunction is a predictor of long term mortality in men but not in women with heart failure. Eur Heart J. 2003;24(22):2046-2053.

    PubMed  Google Scholar 

  223. Stock SA, Stollenwerk B, Redaelli M, Civello D, Lauterbach KW. Sex differences in treatment patterns of six chronic diseases: an analysis from the German statutory health insurance. J Womens Health (Larchmt). 2008;17(3): 343-354.

    Google Scholar 

  224. Baumhakel M, Muller U, Bohm M. Influence of gender of physicians and patients on guideline-recommended treatment of chronic heart failure in a cross-sectional study. Eur J Heart Fail. 2009;11(3):299-303.

    PubMed  Google Scholar 

  225. Rathore SS, Wang Y, Krumholz HM. Sex-based differences in the effect of digoxin for the treatment of heart failure. N Engl J Med. 2002;347(18):1403-1411.

    PubMed  CAS  Google Scholar 

  226. Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA. 2003;289(7):871-878.

    PubMed  CAS  Google Scholar 

  227. Simon T, Mary-Krause M, Funck-Brentano C, Jaillon P. Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II). Circulation. 2001;103(3):375-380.

    PubMed  CAS  Google Scholar 

  228. O’Meara E, Clayton T, McEntegart MB, et al. Sex differences in clinical characteristics and prognosis in a broad spectrum of patients with heart failure: results of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. Circulation. 2007;115(24):3111-3120.

    PubMed  Google Scholar 

  229. Rossouw JE, Prentice RL, Manson JE, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA. 2007;297(13):1465-1477.

    PubMed  CAS  Google Scholar 

  230. Alaeddini J, Wood MA, Amin MS, Ellenbogen KA. Gender disparity in the use of cardiac resynchronization therapy in the United States. Pacing Clin Electrophysiol. 2008;31(4): 468-472.

    PubMed  Google Scholar 

  231. Russo AM, Poole JE, Mark DB, et al. Primary prevention with defibrillator therapy in women: results from the Sudden Cardiac Death in Heart Failure Trial. J Cardiovasc Electrophysiol. 2008;19(7):720-724.

    PubMed  Google Scholar 

  232. Peterson PN, Daugherty SL, Wang Y, et al. Gender differences in procedure-related adverse events in patients receiving implantable cardioverter-defibrillator therapy. Circulation. 2009;119(8):1078-1084.

    PubMed  Google Scholar 

  233. van Bommel RJ, Bax JJ, Abraham WT, et al. Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysis. Eur Heart J. 2009;30(20):2470-2477.

    PubMed  Google Scholar 

  234. De Maria R, Gavazzi A, Recalcati F, Baroldi G, De Vita C, Camerini F. Comparison of clinical findings in idiopathic dilated cardiomyopathy in women versus men. The Italian Multicenter Cardiomyopathy Study Group (SPIC). Am J Cardiol. 1993;72(7):580-585.

    PubMed  Google Scholar 

  235. Aaronson KD, Schwartz JS, Goin JE, Mancini DM. Sex differences in patient acceptance of cardiac transplant candidacy. Circulation. 1995;91(11):2753-2761.

    PubMed  CAS  Google Scholar 

  236. Ghali JK, Krause-Steinrauf HJ, Adams KF, et al. Gender differences in advanced heart failure: insights from the BEST study. J Am Coll Cardiol. 2003;42(12):2128-2134.

    PubMed  Google Scholar 

  237. Mullens W, Abrahams Z, Sokos G, et al. Gender differences in patients admitted with advanced decompensated heart failure. Am J Cardiol. 2008;102(4):454-458.

    PubMed  Google Scholar 

  238. Ng TP, Niti M. Trends and ethnic differences in hospital admissions and mortality for congestive heart failure in the elderly in Singapore, 1991 to 1998. Heart. 2003;89(8):865-870.

    PubMed  CAS  Google Scholar 

  239. Altimir S, Lupon J, Gonzalez B, et al. Sex and age differences in fragility in a heart failure population. Eur J Heart Fail. 2005;7(5):798-802.

    PubMed  Google Scholar 

  240. Okura Y, Ohno Y, Suzuki K, et al. Characterization of outpatients with systolic dysfunction in a Japanese community by total enumeration. Circ J. 2007;71(7):1004-1012.

    PubMed  Google Scholar 

  241. Costello JA, Boblin S. What is the experience of men and women with congestive heart failure? Can J Cardiovasc Nurs. 2004;14(3):9-20.

    PubMed  Google Scholar 

  242. Evangelista LS, Kagawa-Singer M, Dracup K. Gender differences in health perceptions and meaning in persons living with heart failure. Heart Lung. 2001;30(3):167-176.

    PubMed  CAS  Google Scholar 

  243. Lee CH, Liu PY, Lin LJ, Chen JH, Tsai LM. Clinical features and outcome of patients with apical hypertrophic cardiomyopathy in Taiwan. Cardiology. 2006;106(1):29-35.

    PubMed  Google Scholar 

  244. Dimitrow PP, Czarnecka D, Jaszcz KK, Dubiel JS. Sex differences in age at onset of symptoms in patients with hypertrophic cardiomyopathy. J Cardiovasc Risk. 1997;4(1):33-35.

    PubMed  CAS  Google Scholar 

  245. Sliwa K, Hilfiker-Kleiner D, Petrie MC, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail. 2010;12(8):767-778.

    PubMed  Google Scholar 

  246. Arola A, Jokinen E, Ruuskanen O, et al. Epidemiology of idiopathic cardiomyopathies in children and adolescents. A nationwide study in Finland. Am J Epidemiol. 1997;146(5):385-393.

    PubMed  CAS  Google Scholar 

  247. Bagger JP, Baandrup U, Rasmussen K, Moller M, Vesterlund T. Cardiomyopathy in western Denmark. Br Heart J. 1984;52(3):327-331.

    PubMed  CAS  Google Scholar 

  248. Codd MB, Sugrue DD, Gersh BJ, Melton LJ III. Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984. Circulation. 1989;80(3): 564-572.

    PubMed  CAS  Google Scholar 

  249. Gillum RF. Idiopathic cardiomyopathy in the United States, 1970-1982. Am Heart J. 1986;111(4):752-755.

    PubMed  CAS  Google Scholar 

  250. Coughlin SS, Comstock GW, Baughman KL. Descriptive epidemiology of idiopathic dilated cardiomyopathy in Washington County, Maryland, 1975-1991. J Clin Epidemiol. 1993;46(9):1003-1008.

    PubMed  CAS  Google Scholar 

  251. Haddad GE, Saunders LJ, Crosby SD, et al. Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences. Physiol Genomics. 2008; 33(2):267-277.

    PubMed  CAS  Google Scholar 

  252. Palmer BM, Wang Y, Teekakirikul P, et al. Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex. Am J Physiol Heart Circ Physiol. 2008;294(4):H1939-H1947.

    PubMed  CAS  Google Scholar 

  253. Stefanelli CB, Rosenthal A, Borisov AB, Ensing GJ, Russell MW. Novel troponin T mutation in familial dilated cardiomyopathy with gender-dependant severity. Mol Genet Metab. 2004;83(1–2):188-196.

    PubMed  CAS  Google Scholar 

  254. Schulz-Menger J, Abdel-Aty H, Rudolph A, et al. Gender-specific differences in left ventricular remodelling and fibrosis in hypertrophic cardiomyopathy: insights from cardiovascular magnetic resonance. Eur J Heart Fail. 2008;10(9):850-854.

    PubMed  Google Scholar 

  255. Haghighi K, Schmidt AG, Hoit BD, et al. Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure. J Biol Chem. 2001;276(26):24145-24152.

    PubMed  CAS  Google Scholar 

  256. Bevilacqua LM, Maguire CT, Seidman JG, Seidman CE, Berul CI. QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice. Pediatr Res. 1999;45(5 Pt 1):643-647.

    PubMed  CAS  Google Scholar 

  257. Kadokami T, McTiernan CF, Kubota T, Frye CS, Feldman AM. Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression. J Clin Invest. 2000;106(4):589-597.

    PubMed  CAS  Google Scholar 

  258. Gao XM, Agrotis A, Autelitano DJ, et al. Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression. Endocrinology. 2003;144(9):4097-4105.

    PubMed  CAS  Google Scholar 

  259. Duan J, Esberg LB, Ye G, et al. Influence of gender on ethanol-induced ventricular myocyte contractile depression in transgenic mice with cardiac overexpression of alcohol dehydrogenase. Comp Biochem Physiol A Mol Integr Physiol. 2003;134(3):607-614.

    PubMed  Google Scholar 

  260. Wu CF, Sudhaker M, Ghazanfar J, Ahmed SS, Regan TJ. Preclinical cardiomyopathy in chronic alcoholics: a sex difference. Am Heart J. 1976;91(3):281-286.

    PubMed  CAS  Google Scholar 

  261. Ponten A, Li X, Thoren P, et al. Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy. Am J Pathol. 2003;163(2):673-682.

    PubMed  CAS  Google Scholar 

  262. Ding Y, Zou R, Judd RL, Zhong J. Effects of gender difference on cardiac myocyte dysfunction in streptozotocin-induced diabetic rats. Endocrine. 2006;29(1):135-141.

    PubMed  CAS  Google Scholar 

  263. Yan L, Ge H, Li H, et al. Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts. J Mol Cell Cardiol. 2004;37(5):921-929.

    PubMed  CAS  Google Scholar 

  264. Brimacombe M, Walter D, Salberg L. Gender disparity in a large nonreferral-based cohort of hypertrophic cardiomyopathy patients. J Womens Health (Larchmt). 2008; 17(10):1629-1634.

    CAS  Google Scholar 

  265. Ohmoto-Sekine Y, Suzuki J, Shimamoto R, et al. Gender-specific clinical characteristics of deep Q waves in hypertrophic cardiomyopathy. Gend Med. 2007;4(3):274-283.

    PubMed  Google Scholar 

  266. Sharkey SW, Lesser JR, Zenovich AG, et al. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation. 2005;111(4):472-479.

    PubMed  Google Scholar 

  267. Albert CM, Quigg R, Saba S, et al. Sex differences in outcome after implantable cardioverter defibrillator implantation in nonischemic cardiomyopathy. Am Heart J. 2008;156(2):367-372.

    PubMed  Google Scholar 

  268. Chen HA, Hsia HH, Vagelos R, Fowler M, Wang P, Al-Ahmad A. The effect of gender on mortality or appropriate shock in patients with nonischemic cardiomyopathy who have implantable cardioverter-defibrillators. Pacing Clin Electrophysiol. 2007;30(3):390-394.

    PubMed  Google Scholar 

  269. Cetta F, Michels VV. The natural history and spectrum of idiopathic dilated cardiomyopathy, including HIV and peripartum cardiomyopathy. Curr Opin Cardiol. 1995; 10(3):332-338.

    PubMed  CAS  Google Scholar 

  270. Wolbrette D, Patel H. Arrhythmias and women. Curr Opin Cardiol. 1999;14(1):36-43.

    PubMed  CAS  Google Scholar 

  271. Bailey MS, Curtis AB. The effects of hormones on arrhythmias in women. Curr Womens Health Rep. 2002;2(2):83-88.

    PubMed  Google Scholar 

  272. Michelena HI, Ezekowitz MD. Atrial fibrillation: are there gender differences? J Gend Specif Med. 2000;3(6):44-49.

    PubMed  CAS  Google Scholar 

  273. Humphries KH, Kerr CR, Connolly SJ, et al. New-onset atrial fibrillation: sex differences in presentation, treatment, and outcome. Circulation. 2001;103(19):2365-2370.

    PubMed  CAS  Google Scholar 

  274. Wang TJ, Larson MG, Levy D, et al. Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation. 2003;107(23):2920-2925.

    PubMed  Google Scholar 

  275. Wolbrette D, Naccarelli G, Curtis A, Lehmann M, Kadish A. Gender differences in arrhythmias. Clin Cardiol. 2002; 25(2):49-56.

    PubMed  Google Scholar 

  276. Dhala A, Underwood D, Leman R, et al. Signal-averaged P-wave analysis of normal controls and patients with ­paroxysmal atrial fibrillation: a study in gender differences, age dependence, and reproducibility. Clin Cardiol. 2002;25(11):525-531.

    PubMed  Google Scholar 

  277. Paquette M, Roy D, Talajic M, et al. Role of gender and personality on quality-of-life impairment in intermittent atrial fibrillation. Am J Cardiol. 2000;86(7):764-768.

    PubMed  CAS  Google Scholar 

  278. Conway DS, Heeringa J, Van Der Kuip DA, et al. Atrial fibrillation and the prothrombotic state in the elderly: the Rotterdam Study. Stroke. 2003;34(2):413-417.

    PubMed  Google Scholar 

  279. Fuster VRL, Cannom DS, Crijns HJ, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114:e257-e354.

    PubMed  Google Scholar 

  280. Essebag V, Reynolds MR, Hadjis T, et al. Sex differences in the relationship between amiodarone use and the need for permanent pacing in patients with atrial fibrillation. Arch Intern Med. 2007;167(15):1648-1653.

    PubMed  Google Scholar 

  281. Wolbrette DL. Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues. Am J Cardiol. 2003;91(6A):39D-44D.

    PubMed  CAS  Google Scholar 

  282. Basta MN, Leitch JW, Fletcher PJ. Sotalol proarrhythmia: a report of five cases and an audit of the use of a sotalol in a teaching hospital. Aust N Z J Med. 1996;26(2):167-170.

    PubMed  CAS  Google Scholar 

  283. Rienstra M, Van Veldhuisen DJ, Hagens VE, et al. Gender-related differences in rhythm control treatment in persistent atrial fibrillation: data of the Rate Control Versus Electrical Cardioversion (RACE) study. J Am Coll Cardiol. 2005;46(7):1298-1306.

    PubMed  Google Scholar 

  284. Dagres N, Nieuwlaat R, Vardas PE, et al. Gender-related differences in presentation, treatment, and outcome of patients with atrial fibrillation in Europe: a report from the Euro Heart Survey on Atrial Fibrillation. J Am Coll Cardiol. 2007;49(5):572-577.

    PubMed  Google Scholar 

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  1. Institute of Gender in Medicine (GiM), Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin, Berlin, Germany

    Vera Regitz-Zagrosek

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  1. Charite´- Universitätsmedizin Berlin, Institute of Gender in Medicine (GiM), Berlin, 10115, Germany

    Sabine Oertelt-Prigione

  2. Inst. Geschlechterforschung in der, Medizin, Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, Berlin, 10115, Germany

    Vera Regitz-Zagrosek

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Regitz-Zagrosek, V. (2012). Sex and Gender Differences in Cardiovascular Disease. In: Oertelt-Prigione, S., Regitz-Zagrosek, V. (eds) Sex and Gender Aspects in Clinical Medicine. Springer, London. https://doi.org/10.1007/978-0-85729-832-4_4

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