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Pharmacokinetics and Pharmacodynamics: The Role of Sex and Gender

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Sex and Gender Aspects in Clinical Medicine

Abstract

In the last years, the attention versus the influence of sex/gender in the drug response largely increased. Since 2001, the Institute of Medicine indicates that “sex matters,” that is, “being male or female is an important basic human variable that should be considered when designing and analyzing studies in all areas and at all levels of … health-related research.”1 Generally, the FDA does not attempt to determine why men are different from women and refers to any identified difference as a “gender difference.”2

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Acknowledgments

Supposte by grant “La Medicina di Genere come Obiettivo Strategico per la Sanità Pubblica: l’Appropriatezza della Cura per la Tutela della Salute della Donna” Ricerca Finalizzata -Ministero della Salute 2007. We are also grateful for the financial support over the years of Fondazione Banco di Sardegna and that of Regione Autonoma of Sardegna.

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Authors and Affiliations

  1. Department of Pharmacology, University of Sassari, Sassari, Italy

    Flavia Franconi

  2. INBB Laboratorio Nazionale di Osilo, INBB, Sassari, Italy

    Manuela Sanna & Roberto Chessa

  3. Department of Therapeutic Research and Medicine Evaluation Istituto Superiore di Sanità, Istituto Superiore di Sanità, Rome, Italy

    Elisabetta Straface

  4. Dipartimento di Scienze Internistiche, IRCCS San Raffaele Pisana Roma, Rome, Italy

    Giuseppe Rosano

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  1. Flavia Franconi
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  2. Manuela Sanna
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  3. Elisabetta Straface
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  4. Roberto Chessa
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  5. Giuseppe Rosano
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Corresponding author

Correspondence to Flavia Franconi .

Editor information

Editors and Affiliations

  1. Charite´- Universitätsmedizin Berlin, Institute of Gender in Medicine (GiM), Berlin, 10115, Germany

    Sabine Oertelt-Prigione

  2. Inst. Geschlechterforschung in der, Medizin, Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, Berlin, 10115, Germany

    Vera Regitz-Zagrosek

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Franconi, F., Sanna, M., Straface, E., Chessa, R., Rosano, G. (2012). Pharmacokinetics and Pharmacodynamics: The Role of Sex and Gender. In: Oertelt-Prigione, S., Regitz-Zagrosek, V. (eds) Sex and Gender Aspects in Clinical Medicine. Springer, London. https://doi.org/10.1007/978-0-85729-832-4_12

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