Oogenesis pp 75-92 | Cite as

How the Oocyte Influences Follicular Cell Function and Why

  • Martin M. Matzuk
  • Qinglei LiEmail author


During ovarian follicular development, bidirectional communication between oocytes and their companion somatic cells is indispensable. The oocyte plays a leading role in regulating follicular cell development and function including growth and proliferation, apoptosis, differentiation, steroidogenesis, metabolism, and cumulus expansion. By modulating these critical functions, the oocyte orchestrates the rate of follicular development and creates a favorable microenvironment essential for its own development and destiny. A better understanding of the oocyte-somatic cell regulatory loop is essential for unraveling the myths surrounding oocyte developmental competence and may provide novel therapeutic strategies for female reproductive disorders resulting from defects in oocyte-follicle cell interactions.


Oocyte Folliculogenesis Granulosa cells Transforming growth factor β Growth differentiation factor 9 (GDF9) Bone morphogenetic protein 15 



Studies in this area are supported by NIH grants HD33438 and HD32067 (to M. M. M.) and NIH grant HD073756 and Texas A&M new faculty start-up funds (to Q. L.).


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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Departments of Pathology and Immunology, Molecular and Cellular Biology, and Molecular and Human GeneticsBaylor College of MedicineHoustonUSA
  2. 2.Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationUSA

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