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Signaling for Meiotic Resumption in Granulosa Cells, Cumulus Cells, and Oocyte

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Oogenesis

Abstract

Mammalian oocytes are arrested in prophase of meiosis I until a surge of luteinizing hormone from the pituitary signals them to resume meiosis and progress to metaphase II. Prophase arrest prior to the LH surge, and meiotic resumption following the LH surge, are regulated by an interplay between the oocyte and the surrounding follicle cells. This chapter reviews what is currently known about the maintenance of meiotic arrest and the mechanisms that bring about meiotic resumption in the rodent oocyte.

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Acknowledgments

I thank Dr. Laurinda Jaffe and Katie Lowther for helpful comments on the manuscript. This work was supported by a grant from the NIH (HD056366).

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Authors and Affiliations

  1. Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, 06030, USA

    Lisa M. Mehlmann Ph.D.

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  1. Lisa M. Mehlmann Ph.D.
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Correspondence to Lisa M. Mehlmann Ph.D. .

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Editors and Affiliations

  1. BIOGENESI, Instituti Clinici Zucchi, Via Zucchi 24, Monza, 20900, Italy

    Giovanni Coticchio

  2. University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, 66160, USA

    David F. Albertini

  3. Ospedale S. Raffaele, Department of Ob/Gyn, University Vita-Salute, Via Olgettina 60, Milan, 20132, Italy

    Lucia De Santis

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Mehlmann, L.M. (2013). Signaling for Meiotic Resumption in Granulosa Cells, Cumulus Cells, and Oocyte. In: Coticchio, G., Albertini, D., De Santis, L. (eds) Oogenesis. Springer, London. https://doi.org/10.1007/978-0-85729-826-3_12

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