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An Epigenomic Biography of the Mammalian Oocyte

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Oogenesis

Abstract

Successful fertilization and early development depend on the quality of the ovulated oocyte. Our knowledge lacks of links between morphological aspects described and the genomic and epigenomic features that work in the backstage. Bringing to light these links would permit the identification of molecular markers of the oocyte developmental competence. In this chapter, we will review our current understanding of the changes that occur to the oocyte epigenetic signature during folliculogenesis and in mature oocytes.

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Acknowledgments

We thank the following organizations for support: UNIPV-Regione Lombardia, Fondazione Alma Mater Ticinensis, Fondazione I.R.C.C.S. Policlinico San Matteo, and “Bando Giovani Ricercatori 2007” to C.A.R.

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Authors and Affiliations

  1. Dipartimento di Scienze Biomediche, Biotecnologiche e Traslazionali, Universita’ degli Studi di Parma, Via Volturno 39, 43125, Parma, Italy

    Maurizio Zuccotti Ph.D.

  2. Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia Animale, Universita’ degli Studi di Pavia, Via A. Ferrata 9, 27100, Pavia, Italy

    Valeria Merico Ph.D., Carlo Alberto Redi Ph.D. & Silvia Garagna Ph.D.

  3. Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy

    Valeria Merico Ph.D. & Carlo Alberto Redi Ph.D.

  4. Centro di Ingegneria Tissutale, Universita’ degli Studi di Pavia, Pavia, Italy

    Silvia Garagna Ph.D.

  5. Centro di Eccellenza in Biologia Applicata, Universita’ degli Studi di Pavia, Pavia, Italy

    Silvia Garagna Ph.D.

Authors
  1. Maurizio Zuccotti Ph.D.
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  2. Valeria Merico Ph.D.
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  3. Carlo Alberto Redi Ph.D.
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  4. Silvia Garagna Ph.D.
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Corresponding authors

Correspondence to Maurizio Zuccotti Ph.D. or Silvia Garagna Ph.D. .

Editor information

Editors and Affiliations

  1. BIOGENESI, Instituti Clinici Zucchi, Via Zucchi 24, Monza, 20900, Italy

    Giovanni Coticchio

  2. University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, 66160, USA

    David F. Albertini

  3. Ospedale S. Raffaele, Department of Ob/Gyn, University Vita-Salute, Via Olgettina 60, Milan, 20132, Italy

    Lucia De Santis

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Zuccotti, M., Merico, V., Redi, C.A., Garagna, S. (2013). An Epigenomic Biography of the Mammalian Oocyte. In: Coticchio, G., Albertini, D., De Santis, L. (eds) Oogenesis. Springer, London. https://doi.org/10.1007/978-0-85729-826-3_10

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  • DOI: https://doi.org/10.1007/978-0-85729-826-3_10

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