Hughes Syndrome: The Causes – Genetics Versus Environment

  • Graham Hughes
  • Shirish Sangle


Hughes Syndrome is a result of altered immunity. In this instance a family of antibodies – aPL – are closely linked to the disease process. It is still not proven whether this is a cause-and-effect link (e.g., altered phospholipid-membrane structure in platelets and endothelial cells), but the suspicion is there.


Oral Contraceptive Pill Mountain Height Diarrhoeal Illness Initial Clinical Manifestation Cabin Pressure 
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Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  • Graham Hughes
    • 1
  • Shirish Sangle
    • 2
  1. 1.The London Lupus CentreLondon Bridge HospitalLondonUK
  2. 2.Louise Coote Lupus UnitSt Thomas’ HospitalLondonUK

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