Catastrophic APS

  • Graham Hughes
  • Shirish Sangle


In the 1980s with the increasing referral pattern of APS patients to our unit, we began to see cases of acute, widespread thrombotic disease, always requiring the help of the intensive care unit and with a high fatality rate. There was no clear triggering factor, though in one of our cases, the acute collapse occurred in a patient with Hughes Syndrome, whose warfarin was stopped following a head injury.


Intensive Care Unit Head Injury Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Fetal Loss 
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Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  • Graham Hughes
    • 1
  • Shirish Sangle
    • 2
  1. 1.The London Lupus CentreLondon Bridge HospitalLondonUK
  2. 2.Louise Coote Lupus UnitSt Thomas’ HospitalLondonUK

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