Liver and Gut
Hepatic artery thrombosis and liver infarction can occur in APS, as can hepatic venous thrombosis. Budd–Chiari syndrome (thrombosis of the hepatic vein) is a well-known sequel of APS, leading to hepato-splenomegaly (Fig. 16.1). One study has suggested that Hughes Syndrome may be the second commonest cause of Budd–Chiari (second only to lymphoma).