Hematologic and Lymphoid Neoplasia

  • Anne M. Tierens


Serous effusions are commonly seen in lymphomas, in about 20–30% of cases, and are less frequently seen with myeloid malignancy.1,2 In children, effusions are more commonly associated with lymphoma and leukemia than with other malignancies.3 Most effusions are secondary, and are caused by direct infiltration with leukemia or lymphoma from an adjacent disease location, by obstruction of the lymphatic system draining the body cavity by lymphoma or by infection secondary to immune depression due to extensive marrow involvement or secondary to the treatment of lymphoma or leukemia. In addition, effusions may also be caused by inflammation following direct damage by radiation, chemotherapy, and novel tyrosine-kinase inhibitors such as dasatinib or by graft versus host disease in the case of bone marrow transplantation for the malignancy.46 In this section, only serous effusions arising from direct lymphoma or leukemia infiltration of a body cavity will be discussed.


Chronic Myeloid Leukemia Anaplastic Lymphoma Kinase Polycythemia Vera Body Cavity Anaplastic Large Cell Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Alexandrakis MG, Passam FH, Kyriakou DS, Bouros D. Pleural effusions in hematologic malignancies. Chest. 2004;125:1546-1555.PubMedCrossRefGoogle Scholar
  2. 2.
    Das DK. Serous effusions in malignant lymphomas: a review. Diagn Cytopathol. 2006;34:335-347.PubMedCrossRefGoogle Scholar
  3. 3.
    Wong JW, Pitlik D, Abdul-Karim FW. Cytology of pleural, peritoneal and pericardial fluids in children. A 40-year summary. Acta Cytol. 1997;41:467-473.PubMedCrossRefGoogle Scholar
  4. 4.
    Van Renterghem DM, Pauwels RA. Chylothorax and pleural effusion as late complications of thoracic irradiation. Chest. 1995;108:886-887.PubMedCrossRefGoogle Scholar
  5. 5.
    Brixey AG, Light RW. Pleural effusions due to dasatinib. Curr Opin Pulm Med. 2010;16:351-356.PubMedCrossRefGoogle Scholar
  6. 6.
    Seber A, Khan SP, Kersey JH. Unexplained effusions: association with allogeneic bone marrow transplantation and acute or chronic graft-versus-host disease. Bone Marrow Transplant. 1996;17:207-211.PubMedGoogle Scholar
  7. 7.
    Swerdlow SH, Campo E, Harris NL, et al., eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC; 2008.Google Scholar
  8. 8.
    Thompson PA, Lade S, Webster H, Ryan G, Prince HM. Effusion-associated anaplastic large cell lymphoma of the breast: time for it to be defined as a distinct clinico-pathological entity. Haematologica. 2010;95:1977-1979.PubMedCrossRefGoogle Scholar
  9. 9.
    Mitchell A, Meunier C, Ouellette D, Colby T. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with initial presentation in the pleura. Chest. 2006;129:791-794.PubMedCrossRefGoogle Scholar
  10. 10.
    Motta G, Conticello C, Amato G, et al. Pleuric presentation of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a case report and a review of the literature. Int J Hematol. 2010;92:369-373.PubMedCrossRefGoogle Scholar
  11. 11.
    Pullarkat VA, Medeiros LJ, Brynes RK. Body cavity-based presentation of natural killer cell lymphoma. Leuk Lymphoma. 2005;46:293-296.PubMedCrossRefGoogle Scholar
  12. 12.
    Chaves FP, Quillen K, Xu D. Pericardial effusion: a rare presentation of adult T-cell leukemia/lymphoma. Am J Hematol. 2004;77:381-383.PubMedCrossRefGoogle Scholar
  13. 13.
    Czader M, Ali SZ. Flow cytometry as an adjunct to cytomorphologic analysis of serous effusions. Diagn Cytopathol. 2003;29:74-78.PubMedCrossRefGoogle Scholar
  14. 14.
    Bangerter M, Brudler O, Heinrich B, Griesshamnuer M. Fine needle aspiration cytology and flow cytometry in the diagnosis and subclassification of non-Hodgkin’s lymphoma based on the World Health Organization classification. Acta Cytol. 2007;51:390-398.PubMedCrossRefGoogle Scholar
  15. 15.
    Evans PA, Pott Ch, Groenen PJ, et al. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia. 2007;21:207-214.PubMedCrossRefGoogle Scholar
  16. 16.
    Brüggemann M, White H, Gaulard P, et al. Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies. Report of the BIOMED-2 Concerted Action BHM4 CT98-3936. Leukemia. 2007;21:215-221.PubMedCrossRefGoogle Scholar
  17. 17.
    Langerak AW, Molina TJ, Lavender FL, et al. Polymerase chain reaction-based clonality testing in tissue samples with reactive lymphoproliferations: usefulness and pitfalls. A report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2007;21:222-229.PubMedCrossRefGoogle Scholar
  18. 18.
    Mann G, Attarbaschi A, Steiner M, et al. Austrian Berlin-Frankfurt-Münster (BFM) Group. Early and reliable diagnosis of non-Hodgkin lymphoma in childhood and adolescence: contribution of cytomorphology and flow cytometric immunophenotyping. Pediatr Hematol Oncol. 2006;2:167-176.CrossRefGoogle Scholar
  19. 19.
    Mathiot C, Decaudin D, Klijanienko J, et al. Fine-needle aspiration cytology combined with flow cytometry immunophenotyping is a rapid and accurate approach for the evaluation of suspicious superficial lymphoid lesions. Diagn Cytopathol. 2006;34:472-478.PubMedCrossRefGoogle Scholar
  20. 20.
    Mathur S, Dawar R, Verma K. Diagnosis and grading of non-Hodgkin’s lymphomas on fine needle aspiration cytology. Indian J Pathol Microbiol. 2007;50:46-50.PubMedGoogle Scholar
  21. 21.
    Nador RG, Cesarman E, Chadburn A, et al. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus. Blood. 1996;88:645-656.PubMedGoogle Scholar
  22. 22.
    Carbone A, Gloghini A. HHV-8-associated lymphoma: state-of-the-art review. Acta Haematol. 2007;117:129-131.PubMedCrossRefGoogle Scholar
  23. 23.
    Jones D, Ballestas ME, Kaye KM, et al. Primary-effusion lymphoma and Kaposi’s sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998;339:444-449.PubMedCrossRefGoogle Scholar
  24. 24.
    Dotti G, Fiocchi R, Motta T, et al. Primary effusion lymphoma after heart transplantation: a new entity associated with human herpesvirus-8. Leukemia. 1999;13:664-670.PubMedCrossRefGoogle Scholar
  25. 25.
    Ichinohasama R, Miura I, Kobayashi N, et al. Herpes virus type 8-negative primary effusion lymphoma associated with PAX-5 gene rearrangement and hepatitis C virus: a case report and review of the literature. Am J Surg Pathol. 1998;22:1528-1537.PubMedCrossRefGoogle Scholar
  26. 26.
    Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science. 1994;266:1865-1869.PubMedCrossRefGoogle Scholar
  27. 27.
    Du MQ, Bacon CM, Isaacson PG. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders. J Clin Pathol. 2007;60:1350-1357.PubMedCrossRefGoogle Scholar
  28. 28.
    Polskj JM, Evans HL, Grosso LE, Popovic WJ, Taylor L, Dunphy CH. CD7 and CD56-positive primary effusion lymphoma in a human immunodeficiency virus-negative host. Leuk Lymphoma. 2000;39:633-639.PubMedCrossRefGoogle Scholar
  29. 29.
    Chen YB, Rahemtullah A, Hochberg E. Primary effusion lymphoma. Oncologist. 2007;12:569-576.PubMedCrossRefGoogle Scholar
  30. 30.
    Iuchi K, Ichimiya A, Akashi A, et al. Non-Hodgkin’s lymphoma of the pleural cavity developing from long-standing pyothorax. Cancer. 1987;60:1771-1775.PubMedCrossRefGoogle Scholar
  31. 31.
    Aozasa K. Pyothorax-associated lymphoma. J Clin Exp Hematop. 2006;46:5-10.PubMedCrossRefGoogle Scholar
  32. 32.
    Nakatsuka S, Yao M, Hoshida Y, Yamamoto S, Iuchi K, Aozasa K. Pyothorax-associated lymphoma: a review of 106 cases. J Clin Oncol. 2002;20:4255-4260.PubMedCrossRefGoogle Scholar
  33. 33.
    Kuriyama Y, Nakajima A, Shimizu N, Ohyashiki JH, Mukai K, Ohyashiki K. Detection of Epstein-Barr virus in a pyothorax-associated lymphoma with T-cell phenotype. Haematologica. 2002;87:ECR28.PubMedGoogle Scholar
  34. 34.
    Hongyo T, Kurooka M, Taniguchi E, et al. Frequent p53 mutations at dipyrimidine sites in patients with pyothorax-associated lymphoma. Cancer Res. 1998;58:1105-1107.PubMedGoogle Scholar
  35. 35.
    Gaudet G, Friedberg JW, Weng A, Pinkus GS, Freedman AS. Breast lymphoma associated with breast implants: two case-reports and a review of the literature. Leuk Lymphoma. 2002;43:115-119.PubMedCrossRefGoogle Scholar
  36. 36.
    Lipworth L, Tarone RE, McLaughlin JK. Breast implants and lymphoma risk: a review of the epidemiologic evidence through 2008. Plast Reconstr Surg. 2009;123:790-793.PubMedCrossRefGoogle Scholar
  37. 37.
    de Jong D, Vasmel WL, de Boer JP, et al. Anaplastic large-cell lymphoma in women with breast implants. JAMA. 2008;300:2030-2035.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  1. 1.Department of Pathology, Norwegian Radium HospitalOslo University HospitalOsloNorway

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