Cancer of Other Origin



The previous chapters in this section discussed our current knowledge of the biology and clinical relevance of lung, ovarian, and breast carcinoma metastasis in serous effusions, with similar analysis of the native cancer of the serosal cavities, malignant mesothelioma. As discussed in Chap. 5, Part 1, a vast array of malignant tumors may additionally be diagnosed in serous effusions. The majority of these cancers are highly aggressive and their detection in effusion specimens precludes any curative approach, underscoring the need to better characterize them with respect to the presence of potential molecular targets. Initial efforts in this direction include the use of catumaxomab, a trifunctional antibody that binds to EpCAM and CD3, in treating gastric cancer patients with effusions.1 However, the rarity of the majority of these entities has undoubtedly contributed to the scarceness of research aimed at better understanding their biology. The only obvious exception is cancer originating in the gastrointestinal tract (GIT), which has been the subject of a relatively large number of publications. This chapter will consequently focus on these tumors, followed by a brief discussion of the few published investigations of malignant melanoma and sarcomas in effusions.


Gastric Carcinoma Vascular Endothelial Growth Factor Level Malignant Mesothelioma Malignant Ascites Gastric Carcinoma Cell 
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Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  1. 1.Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, The Medical FacultyUniversity of OsloOsloNorway

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