• Declan M. O’Rourke
  • Derek C. Allen


This chapter outlines the anatomy, clinical presentation, and relevant clinical investigations. Details of both non-neoplastic and neoplastic pathological conditions affecting this organ site are given. Clinical considerations in obtaining the diagnostic biopsy and therapeutic resection specimens are outlined with details of their handling and dissection in the histopathology laboratory. This is correlated with relevant histopathology reports, giving summary of core prognostic and patient management items. Current WHO and TNM classifications are referenced.


Prostate Specific Antigen Radical Prostatectomy Seminal Vesicle Gleason Score Digital Rectal Examination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Allen DC, Cameron RI. Histopathology specimens: clinical, pathological and laboratory aspects. 1st ed. Berlin-Heidelberg: Springer; 2004.Google Scholar
  2. Association of Directors of Anatomic and Surgical Pathology. Recommendations for the reporting of prostate carcinoma. Am J Clin Pathol. 2008;129:24–30.CrossRefGoogle Scholar
  3. Bennett VS, Varma M, Bailey DM. Guidelines for the macroscopic processing of radical prostatectomy and pelvic lymphadenectomy specimens. J Clin Pathol. 2008;61:713–21.CrossRefGoogle Scholar
  4. Berney DM, Fisher G, Kattan MW, Oliver RTD, Moller H, Fearn P, Eastham J, Scardino P, Cuzick J, Reuter VE, Foster CS, Trans-Atlantic prostate group. Pitfalls in the diagnosis of prostate cancer: retrospective review of 1791 cases with clinical outcome. Histopathology. 2007;51:452–7.PubMedCrossRefGoogle Scholar
  5. Bostwick DG, Cheng L. Urologic surgical pathology. 2nd ed. Philadelphia: Mosby/Elsevier; 2008.Google Scholar
  6. Eble JN, Sauter G, Epstein JI, Sesterhenn IA. WHO classification of tumours. Pathology and genetics. Tumours of the urinary system and male genital organs. Lyon: IARC Press; 2004.Google Scholar
  7. Egevad L, Algaba F, Berney DM, Boccon-Gibod L, Griffiths DF, Lopez-Beltran A, Mikuz G, Varma M, Montironi R. Handling and reporting of radical prostatectomy specimens in Europe: a web-based survey by the European Network of Uropathology (ENUP). Histopathology. 2008;53:333–9.PubMedCrossRefGoogle Scholar
  8. Epstein JI, Allsbrook WC, Amin MB, Egevad LL, ISUP Grading Committee. The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma. Am J Surg Pathol. 2005;29:1228–42.PubMedCrossRefGoogle Scholar
  9. McNeal JE. Normal histology of the prostate. Am J Surg Pathol. 1998;12(8):619–33.CrossRefGoogle Scholar
  10. Srigley JR, et al. Protocol for the examination of specimens from patients with carcinoma of the prostate gland. Arch Pathol Lab Med. 2009;133(10):1568–76.PubMedGoogle Scholar
  11. The Royal College of Pathologists. Cancer datasets (adult renal parenchymal cancer, renal tumours in childhood, penile cancer, prostatic carcinoma, testicular tumours and post-chemotherapy residual masses, tumours of the urinary collecting system) and tissue pathways (medical renal biopsies, urological pathology). Accessed at Accessed on December 2011.
  12. Vainer B, Toft BG, Olsen KE, Jacobsen GK, Marcussen N. Handling of radical prostatectomy specimens: total or partial embedding? Histopathology. 2011;58:211–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Histopathology LaboratoryBelfast City Hospital, Belfast Health and Social Care TrustBelfastUK

Personalised recommendations