Kidney, Renal Pelvis, and Ureter

  • Declan M. O’Rourke
  • Derek C. Allen


This chapter outlines the anatomy, clinical presentation, and relevant clinical investigations. Details of both non-neoplastic and neoplastic pathological conditions affecting this organ site are given. Clinical considerations in obtaining the diagnostic biopsy and therapeutic resection specimens are outlined, with details of their handling and dissection in the histopathology laboratory. This is correlated with relevant histopathology reports, giving summary core prognostic and patient management items. Current WHO and TNM classifications are referenced.


Renal Cell Carcinoma Renal Tumor Partial Nephrectomy Renal Pelvis Autosomal Dominant Polycystic Kidney Disease 
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  1. Allen DC, Cameron RI. Histopathology specimens: clinical, pathological and laboratory aspects. 1st ed. Berlin-Heidelberg: Springer; 2004.Google Scholar
  2. Association of Directors of Anatomic and Surgical Pathology. Recommendations for the reporting of surgically resected specimens of renal cell carcinoma. Am J Clin Pathol. 2009;131:623–30.CrossRefGoogle Scholar
  3. Bonsib SM. Macroscopic assessment, dissection protocols and histologic sampling strategy for renal cell carcinomas. Diagn Histopathol. 2008;14(4):151–6.CrossRefGoogle Scholar
  4. Bostwick DG, Cheng L. Urologic surgical pathology. 2nd ed. Philadelphia: Mosby/Elsevier; 2008.Google Scholar
  5. D’Agati VD, Jennette JC, Silva FG. Non-neoplastic kidney diseases. Atlas of nontumor pathology. Washington: AFIP; 2005.Google Scholar
  6. Eble JN, Sauter G, Epstein JI, Sesterhenn IA. WHO classification of tumours. Pathology and genetics. Tumours of the urinary system and male genital organs. Lyon: IARC Press; 2004.Google Scholar
  7. Fleming S, Griffiths DFR. Nephrectomy for renal tumour; dissection guide and dataset. ACP best practice no 180. J Clin Pathol. 2005;58:7–14.PubMedCrossRefGoogle Scholar
  8. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;6:655–63.PubMedCrossRefGoogle Scholar
  9. Kovacs G, Akhtar M. The Heidelberg classification of renal cell tumours. J Pathol. 1997;183:131–3.PubMedCrossRefGoogle Scholar
  10. MB. Diagnostic pathology: genitourinary: Amirsys® (Diagnostic pathology series); 2010.Google Scholar
  11. Shah RB, Bakshi N, Hafez K, Wood DP, Kunju LP. Image-guided biopsy in the evaluation of renal mass lesions in contemporary urological practice: indications, adequacy, clinical impact and limitations of the pathological diagnosis. Histopathology. 2005;36:1309–15.Google Scholar
  12. Tavora F, Fajardo DA, Lee TK, Lotan T, Miller JS, Miyamoto H, Epstein JI. Small endoscopic biopsies in the ureter and renal pelvis. Pathologic pitfalls. Am J Surg Pathol. 2009;33:1540–6.PubMedCrossRefGoogle Scholar
  13. The Royal College of Pathologists. Cancer datasets (adult renal parenchymal cancer, renal tumours in childhood, penile cancer, prostatic carcinoma, testicular tumours and post-chemotherapy residual masses, tumours of the urinary collecting system) and tissue pathways (medical renal biopsies, urological pathology). Accessed at Accessed on December 2011.
  14. Thomas JO, Tawfik OW. Recent advances in the diagnosis of renal cell carcinoma. Diagn Histopathol. 2008;14(4):157–63.CrossRefGoogle Scholar
  15. Trpkov K, Yilmaz A, Uzer D, Dishongh KM, Quick CM, Bismar TA, Gokden N. Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. Histopathology. 2010;57:892–906.CrossRefGoogle Scholar
  16. Wittekind C, Greene L, Hutter RVP, Klimfinger M, Sobin LH. TNM atlas: illustrated guide to the TNM/pTNM classification of malignant tumours. 5th ed. Berlin/Heidelberg: Springer; 2005.Google Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Histopathology LaboratoryBelfast City Hospital, Belfast Health and Social Care TrustBelfastUK

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