Charcot Foot and Ankle Disease

  • Ralph Springfeld


Charcot disease of the foot and ankle is still a disease with unknown origin. The associated arthropathy is linked with diabetes mellitus (DM) and peripheral polyneuropathy (PNP). We know about the neuropathic and the vascular theory, called the French and the German theories, respectively.


Achilles Tendon External Fixation Bone Marrow Edema Ankle Fracture Subtalar Joint 
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  1. 1.
    Kessler SB, Kaltheiss TA, Botzlar A. Prinzipien der ­chirurgischen Behandlung bei diabetisch-neuropathischer Osteoarthropathie. Internist. 1999;40:1029-1035.PubMedCrossRefGoogle Scholar
  2. 2.
    Koeck FX, Bobrik V, Fassold A, Grifka J, Kessler S, Straub RH. Marked loss of sympathetic nerve fibers in chronic Charcot foot of diabetic origin compared to ankle joint osteoarthritis. J Orthop Res. 2008;27:736-741.CrossRefGoogle Scholar
  3. 3.
    Pinzur MS, Sostak J. Surgical stabilization of nonplantigrade Charcot arthropathy of the midfoot. Am J Orthop. 2007;36(7):361-365.PubMedGoogle Scholar
  4. 4.
    Jeffcoate WJ. Charcot neuro-osteoarthropathy. Diabetes Metab Res Rev. 2008;24(suppl 1):S62-S65.PubMedCrossRefGoogle Scholar
  5. 5.
    Jeffcoate WJ, Game F, Cavanagh PR. The role of proinflammatory cytokines in the cause of neuropathic osteoarthropathy (acute Charcot foot) in diabetes. Lancet. 2005;366:2058-2061.PubMedCrossRefGoogle Scholar
  6. 6.
    Costigan W, Thordarson DB, Debnath UK. Operative management of ankle fractures in patients with diabetes mellitus. Foot Ankle Int. 2007;28(1):32-37.PubMedCrossRefGoogle Scholar
  7. 7.
    Eichenholtz SN. Charcot Joints. Springfield: Charles C. Thomas; 1966.Google Scholar
  8. 8.
    Sommerey S. Klassifikation des Charcotfußes anhand von klinischen und radiologischen Befunden [Dissertation]. München: LMU; 2004.Google Scholar
  9. 9.
    Sanders LJ, Frykberg RG, The Charcot Foot. In: Bowker JH, Pfeifer MA, Levin and O’Neal’s The Diabetic Foot, 7th ed., Mosby: Philadelphia; 2008:257-283.Google Scholar
  10. 10.
    Armstrong D, Lavery L, Harkless L. Validation of a diabetic wound classification. Diabetes Care. 1998;21(5):855-859.PubMedCrossRefGoogle Scholar
  11. 11.
    Laurinaviciene R, Kirketerp-Moeller K, Holstein PE. Exostectomy for chronic midfoot plantar ulcer in Charcot deformity. J Wound Care. 2008;17(2):53-55. 57-8.PubMedGoogle Scholar
  12. 12.
    Zgonis T, Stapleton JJ, Shibuya N, Roukis TS. Surgically induced Charcot neuroarthropathy following partial forefoot amputation in diabetes. J Wound Care. 2007;16(2):57-59.PubMedGoogle Scholar
  13. 13.
    Brodsky JW. The diabetic foot. In: Mann RA, Coughlin M, eds. Surgery of the Foot and Ankle. St. Louis: CV Mosby; 1994:925-953.Google Scholar
  14. 14.
    de Souza LJ. Charcot arthropathy and immobilization in a weight-bearing total contact cast. J Bone Joint Surg Am. 2008;90(4):754-759.PubMedCrossRefGoogle Scholar
  15. 15.
    Pinzur MS, Sage R, Kaminsky S, Zmuda A. Treatment ­algorithm for neuropathic midfoot deformity. Foot Ankle Int. 1993;14:189-197.Google Scholar
  16. 16.
    Springfeld R. Die distale Neuropathie als Wegweiser für die Therapie knöcherner Fußverletzungen. Chirurgenmagazin. 2009;7:46-48.Google Scholar
  17. 17.
    Springfeld R. Eine Facette des diabetischen Fußsyndroms- der sogenannte Charcotfuß. Orthopädieschuhtechnik. 2009;4:28-34.Google Scholar
  18. 18.
    Schon LC, Weinfeld SB, Horton GA, Resch S. Radiographic and clinical classification of acquired midtarsus deformity. Foot Ankle Int. 1998;19(6):394-404.PubMedGoogle Scholar
  19. 19.
    Schon LC, Easley ME, Weinfeld SB. Charcot neuroarthropathy of foot and ankle. Clin Orthop Relat Res. 1998;349:116-131.PubMedCrossRefGoogle Scholar
  20. 20.
    Sammarco VJ, Sammarco GJ, Walker EW Jr, Guiao RP. Midtarsal arthrodesis in the treatment of charcot midfoot arthropathy. J Bone Joint Surg Am. 2009;91(1):80-91.PubMedCrossRefGoogle Scholar
  21. 21.
    Zgonis T, Roukis TS, Lamm BM. Charcot foot and ankle reconstruction: current thinking and surgical approaches. Clin Podiatr Med Surg. 2007;24(3):505-517.PubMedCrossRefGoogle Scholar
  22. 22.
    Fabrin J, Larsen K, Holstein PE. Arthrodesis with external fixation in the unstable or misaligned Charcot ankle in patients with diabetes mellitus. Int J Low Extrem Wounds. 2007;6(2):102-107.PubMedCrossRefGoogle Scholar
  23. 23.
    Koller A, Hafkemeyer U, Fiedler R, Wetz HH. Rekonstruktive Fußchirurgie bei diabetisch-neuropathischer Osteoarthropathie. Orthopaede. 2004;33:983-991.PubMedGoogle Scholar
  24. 24.
    Zgonis T, Stapleton JJ, Jeffries LC, Girard-Powell VA, Foster LJ. Surgical treatment of Charcot neuropathy. AORN J. 2008;87(5):971-986.PubMedCrossRefGoogle Scholar
  25. 25.
    Grant W, Sullivan R, Sonenshine D, et al. Electron ­microscopic evaluation of the effects of diabetes mellitus on the achilles tendon. J Foot Ankle Surg. 1997;36(4):272-278.PubMedCrossRefGoogle Scholar
  26. 26.
    Ayoub MA. Ankle fractures in diabetic neuropathic arthropathy: can tibiotalar arthrodesis salvage the limb? J Bone Joint Surg Br. 2008;90(7):906-914.PubMedCrossRefGoogle Scholar
  27. 27.
    Baumgartner R, Botta P. Amputationen und Prothesenversorgung. Stuttgart, New York: Thieme Verlag; 2008.Google Scholar
  28. 28.
    Koller A, Fühner J, Wetz HH. Radiologische und klinische Aspekte der dia-betisch-neuropathischen Osteoarthropathie. Orthopade. 2004;33:972-982.PubMedGoogle Scholar
  29. 29.
    Koller A, Wetz HH. Die Operation nach Link-Witzel beim Diabetiker. Orthopade. 2003;32:231-235.PubMedCrossRefGoogle Scholar
  30. 30.
    Koller A, Meissner SA, Podella M, Fiedler R. Orthotic management of Charcot feet after external fixation surgery. Clin Podiatr Med Surg. 2007;24(3):583-599.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  1. 1.HamburgGermany

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