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Abstract

Diabetes is the leading cause of amputation worldwide. It has been said that “every 30 seconds a limb is lost as a consequence of diabetes.”1 In the United States, the annual incidence of lower extremity amputation in those with diabetes is 5–8 per 1,000.2,3 The causes of amputation are well understood. Foot ulcer precedes amputations in 84% of the cases.4 Up to 25% of those with diabetes will develop a foot ulcer over their lifetime.5 More than half of those ulcers will become infected, and 1 in 5 will necessitate an amputation.6 Approximately 60% of the limbs that are amputated are complicated by infection.7 This prompted our group to conceptualize the “steps to an amputation” shown in Fig. 31.1. There are opportunities for intervention at each of these steps, which might prevent the progression of the patient toward the final step – amputation.

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References

  1. “Every thirty seconds, somewhere in the world, a limb is lost as a consequence of diabetes.” Lancet. 2005;366:Cover.

    Google Scholar 

  2. Ollendorf DA, Kotsanos JG, Wishner WJ, Friedman M, Cooper T, Bittoni M. Potential economic benefits of lower extremity amputation prevention strategies in diabetes. Diabetes Care. 1998;21:1240-1245.

    Article  PubMed  CAS  Google Scholar 

  3. Jeffcoate WJ. The incidence of amputation in diabetes. Acta Chir Belg. 2005;105(2):140-144.

    PubMed  CAS  Google Scholar 

  4. Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation: basis for prevention. Diabetes Care. 1990;13:513-521.

    Article  PubMed  CAS  Google Scholar 

  5. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA. 2005;293(2):217-228.

    Article  PubMed  CAS  Google Scholar 

  6. Lavery LA, Wunderlich RP, Tredwell JL. Disease management for the diabetic foot: effectiveness of a diabetic foot prevention program to reduce amputations and hospitalizations. Diabetes Res Clin Pract. 2005;70(1):31-37.

    Article  PubMed  Google Scholar 

  7. Lipsky BA, Berendt AR, Embil J, De Lalla F. Diagnosing and treating diabetic foot infections. Diabetes Metab Res Rev. 2004;20(suppl 1):S56-S64.

    Article  PubMed  Google Scholar 

  8. Armstrong DG, Wrobel J, Robbins JM. Guest Editorial: are diabetes-related wounds and amputations worse than cancer? Int Wound J. 2007;4(4):286-287.

    Article  PubMed  Google Scholar 

  9. Goldner MG. The fate of the second leg in the diabetic amputee. Diabetes. 1960;9:100-103.

    PubMed  CAS  Google Scholar 

  10. Waters RL, Perry J, Antonelle D, Hislop H. Energy cost of walking of amputees: the influence of level of amputation. J Bone Joint Surg Am. 1976;58:42-46.

    PubMed  CAS  Google Scholar 

  11. Rogers LC, Lavery LA, Armstrong DG. The right to bear legs – an amendment to healthcare; how preventing amputations can save billions to the US health-care system. J Am Podiatr Med Assoc. 2008;98(2):166-168.

    PubMed  Google Scholar 

  12. Canavan RJ, Unwin NC, Kelly WF, Connolly VM. Diabetes and non-diabetes related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care continuous longitudinal monitoring using a standard method. Diabetes Care. 2007;31:459-463. Epub Dec 10, 2007.

    Article  PubMed  Google Scholar 

  13. Driver VR, Madsen J, Goodman RA. Reducing amputation rates in patients with diabetes at a military medical center: the limb preservation service model. Diabetes Care. 2005;28(2):248-253.

    Article  PubMed  Google Scholar 

  14. Rogers LC, Bevilacqua NJ. Organized programs reduce major amputations. J Am Podiatr Med Assoc. 2010;100(2):101-104.

    PubMed  Google Scholar 

  15. Armstrong DG, Perales TA, Murff RT, Edelson GW, Welchon JG. Value of white blood cell count with differential in the acute diabetic foot infection. J Am Podiatr Med Assoc. 1996;86(5):224-227.

    PubMed  CAS  Google Scholar 

  16. Lavery LA, Armstrong DG, Quebedeaux TL, Walker SC. Puncture wounds: the frequency of normal laboratory values in the face of severe foot infections of the foot in diabetic and non-diabetic adults. Am J Med. 1996;101:521-525.

    Article  PubMed  CAS  Google Scholar 

  17. Cruciani M, Lipsky BA, Mengoli C, de Lalla F. Are granulocyte colony-stimulating factors beneficial in treating diabetic foot infections?: a meta-analysis. Diabetes Care. 2005;28(2):454-460.

    Article  PubMed  CAS  Google Scholar 

  18. Ballard JL, Eke CC, Bunt TJ, Killeen JD. A prospective evaluation of transcutaneous oxygen measurements in the management of diabetic foot problems. J Vasc Surg. 1995;22(4):485-490. discussion 490-492.

    Article  PubMed  CAS  Google Scholar 

  19. Bunt TJ, Holloway GA. TcPO2 as an accurate predictor of therapy in limb salvage. Ann Vasc Surg. 1996;10(3):224-227.

    Article  PubMed  CAS  Google Scholar 

  20. Adera HM, James K, Castronuovo JJ Jr, Byrne M, Deshmukh R, Lohr J. Prediction of amputation wound healing with skin perfusion pressure. J Vasc Surg. 1995;21(5):823-828. discussion 828-829.

    Article  PubMed  CAS  Google Scholar 

  21. Khaodhiar L, Dinh T, Schomacker KT, et al. The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes. Diabetes Care. 2007;30(4):903-910.

    Article  PubMed  Google Scholar 

  22. Yu GV, Schinke TL, Meszaros A. Syme’s amputation: a retrospective review of 10 cases. Clin Podiatr Med Surg. 2005;22(3):395-427.

    Article  PubMed  Google Scholar 

  23. Pinzur MS, Stuck RM, Sage R, Hunt N, Rabinovich Z. Syme ankle disarticulation in patients with diabetes. J Bone Joint Surg Am. 2003;85-A(9):1667-1672.

    PubMed  Google Scholar 

  24. Armstrong DG, Lavery LA, van Houtum WH, Harkless LB. Amputation and reamputation of the diabetic foot. J Am Podiatr Med Assoc. 1997;87(6):255-259.

    PubMed  CAS  Google Scholar 

  25. Attinger CE, Bulan EJ. Debridement. The key initial first step in wound healing. Foot Ankle Clin. 2001;6(4):627-660.

    Article  PubMed  CAS  Google Scholar 

  26. Attinger CE, Bulan E, Blume PA. Surgical debridement: the key to successful wound healing and reconstruction. Clin Podiatr Med Surg. 2000;17(4):599-630.

    PubMed  CAS  Google Scholar 

  27. Armstrong DG, Lavery LA. Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial. Lancet. 2005;366(9498):1704-1710.

    Article  PubMed  Google Scholar 

  28. Julien PH, Marcinko DE, Gordon S. Reconstruction of soft tissue defects about the great toe. J Foot Surg. 1988;27(2):116-120.

    PubMed  CAS  Google Scholar 

  29. Murdoch DP, Armstrong DG, Dacus JB, Laughlin TJ, Morgan CB, Lavery LA. The natural history of great toe amputations. J Foot Ankle Surg. 1997;36(3):204-208.

    Article  PubMed  CAS  Google Scholar 

  30. Dalla Paola L, Faglia E, Caminiti M, Clerici G, Ninkovic S, Deanesi V. Ulcer recurrence following first ray amputation in diabetic patients: a cohort prospective study. Diabetes Care. 2003;26(6):1874-1878.

    Article  PubMed  Google Scholar 

  31. Bevilacqua NJ, Rogers LC, DellaCorte MP, Armstrong DG. The narrowed forefoot at 1 year: an advanced approach for wound closure after central ray amputations. Clin Podiatr Med Surg. 2008;25(1):127-133.

    Article  PubMed  Google Scholar 

  32. Strauss MB, Bryant BJ, Hart JD. Forefoot narrowing with external fixation for problem cleft wounds. Foot Ankle Int. 2002;23(5):433-439.

    PubMed  Google Scholar 

  33. Oznur A, Tokgozoglu M. Closure of central defects of the forefoot with external fixation: a case report. J Foot Ankle Surg. 2004;43(1):56-59.

    Article  PubMed  Google Scholar 

  34. Zgonis T, Oznur A, Roukis TS. A novel technique for closing difficult diabetic cleft foot wounds with skin grafting and a ring-type external fixation system. Oper Tech Orthop. 2006;2006(16):38-43.

    Article  Google Scholar 

  35. Bernstein B, Guerin L. The use of mini external fixation in central forefoot amputations. J Foot Ankle Surg. 2005;44(4):307-310.

    Article  PubMed  Google Scholar 

  36. Attinger CE, Janis JE, Steinberg J, Schwartz J, Al-Attar A, Couch K. Clinical approach to wounds: debridement and wound bed preparation including the use of dressings and wound-healing adjuvants. Plast Reconstr Surg. 2006;117(7 suppl):72S-109S.

    Article  PubMed  CAS  Google Scholar 

  37. Wallace GF, Stapleton JJ. Transmetatarsal amputations. Clin Podiatr Med Surg. 2005;22(3):365-384.

    Article  PubMed  Google Scholar 

  38. Schweinberger MH, Roukis TS. Soft-tissue and osseous techniques to balance forefoot and midfoot amputations. Clin Podiatr Med Surg. 2008;25(4):623-639. viii-ix.

    Article  PubMed  Google Scholar 

  39. Roukis TS. Flexor hallucis longus and extensor digitorum longus tendon transfers for balancing the foot following transmetatarsal amputation. J Foot Ankle Surg. 2009;48(3):398-401.

    Article  PubMed  Google Scholar 

  40. Schweinberger MH, Roukis TS. Intramedullary screw fixation for balancing of the dysvascular foot following transmetatarsal amputation. J Foot Ankle Surg. 2008;47(6):594-597.

    Article  PubMed  Google Scholar 

  41. Clark JC, Mills JL, Armstrong DG. A Method of external fixation to offload and protect the high-risk foot following reconstruction: the SALSAstand. Eplasty. 2009;9:e21.

    PubMed  Google Scholar 

  42. Mueller MJ, Allen BT, Sinacore DR. Incidence of skin breakdown and higher amputation after transmetatarsal amputation: implications for rehabilitation. Arch Phys Med Rehabil. 1995;76(1):50-54.

    Article  PubMed  CAS  Google Scholar 

  43. Frykberg RG, Abraham S, Tierney E, Hall J. Syme amputation for limb salvage: early experience with 26 cases. J Foot Ankle Surg. 2007;46(2):93-100.

    Article  PubMed  Google Scholar 

  44. Wagner FW Jr. Amputations of the foot and ankle. Current status. Clin Orthop Relat Res. 1977;122:62-69.

    PubMed  Google Scholar 

  45. Pinzur MS, Smith D, Osterman H. Syme ankle disarticulation in peripheral vascular disease and diabetic foot infection: the one-stage versus two-stage procedure. Foot Ankle Int. 1995;16(3):124-127.

    PubMed  CAS  Google Scholar 

  46. Randall DB, Phillips J, Ianiro G. Partial calcanectomy for the treatment of recalcitrant heel ulcerations. J Am Podiatr Med Assoc. 2005;95(4):335-341.

    PubMed  Google Scholar 

  47. Perez ML, Wagner SS, Yun J. Subtotal calcanectomy for chronic heel ulceration. J Foot Ankle Surg. 1994;33(6):572-579.

    PubMed  CAS  Google Scholar 

  48. Smith DG, Stuck RM, Ketner L, Sage RM, Pinzur MS. Partial calcanectomy for the treatment of large ulcerations of the heel and calcaneal osteomyelitis. An amputation of the back of the foot. J Bone Joint Surg Am. 1992;74(4):571-576.

    PubMed  CAS  Google Scholar 

  49. Baumhauer JF, Fraga CJ, Gould JS, Johnson JE. Total ­calcanectomy for the treatment of chronic calcaneal ­osteomyelitis. Foot Ankle Int. 1998;19(12):849-855.

    PubMed  CAS  Google Scholar 

  50. Rogers LC, Bevilacqua NJ, Frykberg RG. Limb salvage with partial calcanectomy; a case series of 21 procedures. Paper presented at: American Podiatric Medical Association, August 2007; Philadelphia, PA.

    Google Scholar 

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Correspondence to Nicholas J. Bevilacqua D.P.M. .

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Bevilacqua, N.J., Rogers, L.C., Armstrong, D.G. (2012). Pedal Amputations in Diabetes. In: Saxena, A. (eds) International Advances in Foot and Ankle Surgery. Springer, London. https://doi.org/10.1007/978-0-85729-609-2_31

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  • DOI: https://doi.org/10.1007/978-0-85729-609-2_31

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