• John W. Devlin


Most critically ill patients undergoing mechanical ventilation require the ­administration of at least two different sedative agents for a median of 3 (interquartile range 2–6) days to optimize patient comfort and safety, facilitate patient-ventilator synchrony and optimize oxygenation.1,2 With an increasing number of safety ­concerns associated with the administration of sedatives, the likelihood of patients experiencing an adverse drug event during their ICU admission is high.3 While many adverse effects are common pharmacologic manifestations of an agent (e.g., dexmedetomidine-associated bradycardia) and therefore frequently reversible, ­others are idiosyncratic (e.g., propofol-related infusion syndrome), unexpected, and may be associated with substantial morbidity and mortality.4,5


Renal Replacement Therapy Continuous Renal Replacement Therapy Adverse Drug Event Therapeutic Hypothermia Inactive Metabolite 
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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Pharmacy PracticeNortheastern UniversityBostonUSA

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