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Stereotactic Body Radiotherapy for Bone and Soft Tissue Sarcoma

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Abstract

Sarcomas are considered radioresitant and surgery has remained the primary treatment. Adjuvant radiation in the pre and post-operative setting has been shown to improve local control. When adjacent normal tissues limit radiation dose, particularly in the recurrent and metastatic setting, conformal radiation techniques like Stereotactic Body Radiotherapy (SBRT), could be a useful treatment modality. This Chapter discusses the role of SBRT in the treatment of soft tissue sarcomas.

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References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29.

    Article  PubMed  Google Scholar 

  2. Yang JC, Chang AE, Baker AR, Sindelar WF, Danforth DN, Topalian SL, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16(1):197–203.

    CAS  PubMed  Google Scholar 

  3. Pisters PW, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996;14(3):859–68.

    CAS  PubMed  Google Scholar 

  4. O’Sullivan B, Davis AM, Turcotte R, Bell R, Catton C, Chabot P, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 2002;359(9325):2235–41.

    Article  PubMed  Google Scholar 

  5. Davis AM, O’Sullivan B, Turcotte R, Bell R, Catton C, Chabot P, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol. 2005;75(1):48–53.

    Article  PubMed  Google Scholar 

  6. Strander H, Turesson I, Cavallin-Ståhl E. A systematic overview of radiation therapy effects in soft tissue sarcomas. Acta Oncol. 2003;42(5–6):516–31.

    Article  PubMed  Google Scholar 

  7. Haas RLM, DeLaney TF, O’Sullivan B, Keus RB, Le Pechoux C, Olmi P, et al. Radiotherapy for management of extremity soft tissue sarcomas: why, when, and where? Int J Radiat Oncol Biol Phys. 2012;84(3):572–80.

    Article  PubMed  Google Scholar 

  8. Koshy M, Rich SE, Mohiuddin MM. Improved survival with radiation therapy in high-grade soft tissue sarcomas of the extremities: a SEER analysis. Int J Radiat Oncol Biol Phys. 2010;77(1):203–9.

    Article  PubMed  Google Scholar 

  9. Alektiar KM, Velasco J, Zelefsky MJ, Woodruff JM, Lewis JJ, Brennan MF. Adjuvant radiotherapy for margin-positive high-grade soft tissue sarcoma of the extremity. Int J Radiat Oncol Biol Phys. 2000;48(4):1051–8.

    Article  CAS  PubMed  Google Scholar 

  10. Potluri S, Jefferies SJ, Jena R, Harris F, Burton KE, Prevost AT, et al. Residual postoperative tumour volume predicts outcome after high-dose radiotherapy for chordoma and chondrosarcoma of the skull base and spine. Clin Oncol (R Coll Radiol). 2011;23(3):199–208.

    Article  CAS  Google Scholar 

  11. Strike SA, McCarthy EF. Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. Iowa Orthop J. 2011;31:154–9.

    PubMed Central  PubMed  Google Scholar 

  12. Chen Y-L, Liebsch N, Kobayashi W, Goldberg S, Kirsch D, Calkins G, et al. Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas. Spine. 2013;38(15):E930–6.

    Article  PubMed  Google Scholar 

  13. Novais EN, Demiralp B, Alderete J, Larson MC, Rose PS, Sim FH. Do surgical margin and local recurrence influence survival in soft tissue sarcomas? Clin Orthop. 2010;468(11):3003–11.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Kepka L, DeLaney TF, Suit HD, Goldberg SI. Results of radiation therapy for unresected soft-tissue sarcomas. Int J Radiat Oncol Biol Phys. 2005;63(3):852–9.

    Article  PubMed  Google Scholar 

  15. Weber DC, Rutz HP, Bolsi A, Pedroni E, Coray A, Jermann M, et al. Spot scanning proton therapy in the curative treatment of adult patients with sarcoma: the Paul Scherrer institute experience. Int J Radiat Oncol Biol Phys. 2007;69(3):865–71.

    Article  PubMed  Google Scholar 

  16. Jereczek-Fossa BA, Bossi-Zanetti I, Mauro R, Beltramo G, Fariselli L, Bianchi LC, et al. CyberKnife robotic image-guided stereotactic radiotherapy for oligometastic cancer: a prospective evaluation of 95 patients/118 lesions. Strahlenther Onkol. 2013;189(6):448–55.

    Article  CAS  PubMed  Google Scholar 

  17. Siva S, MacManus M, Ball D. Stereotactic radiotherapy for pulmonary oligometastases: a systematic review. J Thorac Oncol. 2010;5(7):1091–9.

    PubMed  Google Scholar 

  18. Martin JJ, Niranjan A, Kondziolka D, Flickinger JC, Lozanne KA, Lunsford LD. Radiosurgery for chordomas and chondrosarcomas of the skull base. J Neurosurg. 2007;107(4):758–64.

    Article  PubMed  Google Scholar 

  19. Hasegawa T, Ishii D, Kida Y, Yoshimoto M, Koike J, Iizuka H. Gamma Knife surgery for skull base chordomas and chondrosarcomas. J Neurosurg. 2007;107(4):752–7.

    Article  PubMed  Google Scholar 

  20. Koga T, Shin M, Saito N. Treatment with high marginal dose is mandatory to achieve long-term control of skull base chordomas and chondrosarcomas by means of stereotactic radiosurgery. J Neurooncol. 2010;98(2):233–8.

    Article  PubMed  Google Scholar 

  21. Iyer A, Kano H, Kondziolka D, Liu X, Niranjan A, Flickinger JC, et al. Stereotactic radiosurgery for intracranial chondrosarcoma. J Neurooncol. 2012;108(3):535–42.

    Article  PubMed  Google Scholar 

  22. Chang UK, Cho WI, Lee DH, Kim MS, Cho CK, Lee SY, et al. Stereotactic radiosurgery for primary and metastatic sarcomas involving the spine. J Neurooncol. 2012;107(3):551–7.

    Article  CAS  PubMed  Google Scholar 

  23. Castelli J, Thariat J, Benezery K, Courdi A, Chanalet S, Paquis P, et al. Spinals and paraspinals tumors treated by CyberKnife: feasibility and efficacy. Cancer Radiothér. 2010;14(1):5–10.

    Article  CAS  PubMed  Google Scholar 

  24. Soltys SG, Kalani MYS, Cheshier SH, Szabo KA, Lo A, Chang SD. Stereotactic radiosurgery for a cardiac sarcoma: a case report. Technol Cancer Res Treat. 2008;7(5):363–8.

    Article  PubMed  Google Scholar 

  25. Scheithauer BW, Silva AI, Kattner K, Seibly J, Oliveira AM, Kovacs K. Synovial sarcoma of the sellar region. Neuro Oncol. 2007;9(4):454–9.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Cummings M, Chowdhry V, Shah H, Back J, Kennedy GA. Recurrent meningeal sarcoma successfully treated with stereotactic radiosurgery. J Neurosurg Pediatr. 2012;10(5):434–8.

    Article  PubMed  Google Scholar 

  27. Treasure T, Fiorentino F, Scarci M, Møller H, Utley M. Pulmonary metastasectomy for sarcoma: a systematic review of reported outcomes in the context of Thames Cancer Registry data. BMJ Open. 2012;2(5). http://www.ncbi.nlm.nih.gov/pubmed/23048062.

  28. Bedi M, King DM, Charlson J, Whitfield R, Hackbarth DA, Zambrano EV, et al. Multimodality management of metastatic patients with soft tissue sarcomas may prolong survival. Am J Clin Oncol. 2014;37(3):272–7.

    Google Scholar 

  29. Pfannschmidt J, Egerer G, Bischof M, Thomas M, Dienemann H. Surgical intervention for pulmonary metastases. Dtsch Ärztebl Int. 2012;109(40):645–51.

    PubMed  Google Scholar 

  30. Koelblinger C, Strauss S, Gillams A. Outcome after radiofrequency ablation of sarcoma lung metastases. Cardiovasc Intervent Radiol. 2014;37(1):147–53.

    Article  PubMed  Google Scholar 

  31. Dhakal S, Corbin KS, Milano MT, Philip A, Sahasrabudhe D, Jones C, et al. Stereotactic body radiotherapy for pulmonary metastases from soft-tissue sarcomas: excellent local lesion control and improved patient survival. Int J Radiat Oncol Biol Phys. 2012;82(2):940–5.

    Article  PubMed  Google Scholar 

  32. Levine AM, Coleman C, Horasek S. Stereotactic radiosurgery for the treatment of primary sarcomas and sarcoma metastases of the spine. Neurosurgery. 2009;64(2 Suppl):A54–9.

    Article  PubMed  Google Scholar 

  33. Flannery T, Kano H, Niranjan A, Monaco 3rd EA, Flickinger JC, Kofler J, et al. Gamma knife radiosurgery as a therapeutic strategy for intracranial sarcomatous metastases. Int J Radiat Oncol Biol Phys. 2010;76(2):513–9.

    Article  PubMed  Google Scholar 

  34. Chang EL, Selek U, Hassenbusch 3rd SJ, Maor MH, Allen PK, Mahajan A, et al. Outcome variation among “radioresistant” brain metastases treated with stereotactic radiosurgery. Neurosurgery. 2005;56(5):936–45; discussion 936–945.

    PubMed  Google Scholar 

  35. White IM, Wunder JS, Bell RS, et al. Histological assessment of peritumoral edema in soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2005;61(5):1439–45.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Mary Ann Stevenson MD, PhD & Anand Mahadevan MD, FRCS, FRCR

  2. Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Megan E. Anderson MD

  3. Department of Clinical Oncology, University College London Hospitals, London, UK

    Anna Cassoni FRCR

Authors
  1. Mary Ann Stevenson MD, PhD
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  2. Anand Mahadevan MD, FRCS, FRCR
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  3. Megan E. Anderson MD
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  4. Anna Cassoni FRCR
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Corresponding author

Correspondence to Anand Mahadevan MD, FRCS, FRCR .

Editor information

Editors and Affiliations

  1. Guy's Hospital, London, United Kingdom

    Andrew Gaya

  2. Dept. Radiation Oncology, Harvard Medical School Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

    Anand Mahadevan

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© 2015 Springer-Verlag London

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Stevenson, M.A., Mahadevan, A., Anderson, M.E., Cassoni, A. (2015). Stereotactic Body Radiotherapy for Bone and Soft Tissue Sarcoma. In: Gaya, A., Mahadevan, A. (eds) Stereotactic Body Radiotherapy. Springer, London. https://doi.org/10.1007/978-0-85729-597-2_17

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  • DOI: https://doi.org/10.1007/978-0-85729-597-2_17

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-596-5

  • Online ISBN: 978-0-85729-597-2

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