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Stereotactic Body Radiotherapy for Renal Cancer

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Abstract

Surgery is the primary treatment for renal cancer. However, with inadequate renal function or in patients with solitary kidneys, it may not be a safe function preserving option. When surgery is not desirable other ablative therapies such as radiofrequency ablation or SBRT have been used. Conventional external beam radiation has limited value and can be toxic to the remaining kidney or the surrounding organs. Highly conformal stereotactic body radiotherapy (SBRT) can be an effective and safe nonsurgical option for selected renal cancers.

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References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11–30.

    Article  PubMed  Google Scholar 

  2. Butler BP, Novick AC, Miller DP, Campbell SA, Licht MR. Management of small unilateral renal cell carcinomas: radical versus nephron-sparing surgery. Urology. 1995;45(1):34–40; discussion 40–41.

    Article  CAS  PubMed  Google Scholar 

  3. Barbalias GA, Liatsikos EN, Tsintavis A, Nikiforidis G. Adenocarcinoma of the kidney: nephron-sparing surgical approach vs. radical nephrectomy. J Surg Oncol. 1999;72(3):156–61.

    Article  CAS  PubMed  Google Scholar 

  4. Leibovich BC, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy. J Urol. 2004;171(3):1066–70.

    Article  PubMed  Google Scholar 

  5. Adkins KL, Chang SS, Cookson MS, Smith JA. Partial nephrectomy safely preserves renal function in patients with a solitary kidney. J Urol. 2003;169(1):79–81.

    Article  PubMed  Google Scholar 

  6. Lane BR, Gill IS. 5-Year outcomes of laparoscopic partial nephrectomy. J Urol. 2007;177(1):70–4; discussion 74.

    Article  PubMed  Google Scholar 

  7. Huang WC, Levey AS, Serio AM, Snyder M, Vickers AJ, Raj GV, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006;7(9):735–40.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Lane BR, Novick AC, Babineau D, Fergany AF, Kaouk JH, Gill IS. Comparison of laparoscopic and open partial nephrectomy for tumor in a solitary kidney. J Urol. 2008;179(3):847–51; discussion 852.

    Article  PubMed  Google Scholar 

  9. Kunkle DA, Uzzo RG. Cryoablation or radiofrequency ablation of the small renal mass: a meta-analysis. Cancer. 2008;113(10):2671–80.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Lucas SM, Stern JM, Adibi M, Zeltser IS, Cadeddu JA, Raj GV. Renal function outcomes in patients treated for renal masses smaller than 4 cm by ablative and extirpative techniques. J Urol. 2008;179(1):75–9; discussion 79–80.

    Article  PubMed  Google Scholar 

  11. Juusela H, Malmio K, Alfthan O, Oravisto KJ. Preoperative irradiation in the treatment of renal adenocarcinoma. Scand J Urol Nephrol. 1977;11(3):277–81.

    Article  CAS  PubMed  Google Scholar 

  12. Kjaer M, Iversen P, Hvidt V, Bruun E, Skaarup P, Bech Hansen J, et al. A randomized trial of postoperative radiotherapy versus observation in stage II and III renal adenocarcinoma. A study by the Copenhagen Renal Cancer Study Group. Scand J Urol Nephrol. 1987;21(4):285–9.

    Article  CAS  PubMed  Google Scholar 

  13. Wersall PJ, Blomgren H, Lax I, Kalkner K-M, Linder C, Lundell G, et al. Extracranial stereotactic radiotherapy for primary and metastatic renal cell carcinoma. Radiother Oncol. 2005;77(1):88–95.

    Article  PubMed  Google Scholar 

  14. Finney R. The value of radiotherapy in the treatment of hypernephroma—a clinical trial. Br J Urol. 1973;45(3):258–69.

    Article  CAS  PubMed  Google Scholar 

  15. Svedman C, Sandström P, Pisa P, Blomgren H, Lax I, Kälkner K-M, et al. A prospective Phase II trial of using extracranial stereotactic radiotherapy in primary and metastatic renal cell carcinoma. Acta Oncol. 2006;45(7):870–5.

    Article  PubMed  Google Scholar 

  16. Ponsky LE, Crownover RL, Rosen MJ, Rodebaugh RF, Castilla EA, Brainard J, et al. Initial evaluation of Cyberknife technology for extracorporeal renal tissue ablation. Urology. 2003;61(3):498–501.

    Article  PubMed  Google Scholar 

  17. Beitler JJ, Makara D, Silverman P, Lederman G. Definitive, high-dose-per-fraction, conformal, stereotactic external radiation for renal cell carcinoma. Am J Clin Oncol. 2004;27(6):646–8.

    Article  PubMed  Google Scholar 

  18. Ponsky LE, Mahadevan A, Gill IS, Djemil T, Novick AC. Renal radiosurgery: initial clinical experience with histological evaluation. Surg Innov. 2007;14(4):265–9.

    Article  PubMed  Google Scholar 

  19. Hong Y. Cyberknife radiosurgical ablation of primary renal tumors. J Endourol. 2008;22(S1):A1–310.

    Article  Google Scholar 

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Correspondence to Irving D. Kaplan MD .

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© 2015 Springer-Verlag London

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Kaplan, I.D., Mahadevan, A., Wagner, A.A. (2015). Stereotactic Body Radiotherapy for Renal Cancer. In: Gaya, A., Mahadevan, A. (eds) Stereotactic Body Radiotherapy. Springer, London. https://doi.org/10.1007/978-0-85729-597-2_12

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  • DOI: https://doi.org/10.1007/978-0-85729-597-2_12

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-596-5

  • Online ISBN: 978-0-85729-597-2

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