Tissue fluid is the basic fluid forming lymph. It is the capillary filtrate derived from plasma by diffusion, filtration, and vesicular transport mixed with the preexisting mobile intercellular fluid, containing local cell-produced proteins. It contains all the protein fractions of plasma, but at lower levels. Because of the sieving mechanism that occurs during transport of macromolecules across the capillary wall, the percentage of the total protein that is contributed by the small molecular weight proteins tends to be greater than that in serum. There is still a lack of evidence that, in the steady state, the protein concentration in afferent prenodal lymph differs from that of interstitial fluid. Most authors assume that the lymph protein concentration is identical to that in the interstitium. This applies to both normal and lymphedema conditions.
Basic Fluid Total Protein Concentration Capillary Wall Tissue Fluid Oncotic Pressure
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Olszewski WL, Engeset A, Sokolowski J. Lymph flow and protein in the normal male leg during lying, getting up, and walking. Lymphology. 1977;10(3):178-83.PubMedGoogle Scholar
Olszewski W, Engeset A, Jaeger PM, Sokolowski J, Theodorsen L. Flow and composition of leg lymph in normal men during venous stasis, muscular activity and local hyperthermia. Acta Physiol Scand. 1977;99(2):149-55.PubMedCrossRefGoogle Scholar
Olszewski WL, Engeset A, Lukasiewicz H. Immunoglobulins, complement and lysozyme in leg lymph of normal men. Scand J Clin Lab Invest. 1977;37(8):669-74.PubMedCrossRefGoogle Scholar
Olszewski WL, Engeset A. Haemolytic complement in peripheral lymph of normal men. Clin Exp Immunol. 1978;32(3):392-8.PubMedGoogle Scholar
Olszewski WL, Engeset A. Immune proteins, enzymes and electrolytes in human peripheral lymph. Lymphology. 1978;11(4):156-64.PubMedGoogle Scholar
Olszewski WL. Lymph protein concentration. In Lymph stasis – pathomechanism, diagnosis and therapy. Boca Raton: CRC Press; 1991:243-56.Google Scholar
Interewicz B, Olszewski WL, Leak LV, Petricoin EF, Liotta LA. Profiling of normal human leg lymph proteins using the 2-D electrophoresis and SELDI-TOF mass spectrophotometry approach. Lymphology. 2004;37(2):65-72.PubMedGoogle Scholar
Plachta J, Olszewski WL, Grzelak I, Engeset A, Cholewka W. Identification of interleukin-1 in normal human lymph derived from skin. Lymphokine Res. 1988;7(2):93-7.PubMedGoogle Scholar
Olszewski WL, Loe K, Engeset A. Immune proteins and other biochemical constituents of peripheral lymph in patients with malignancy and postirradiation lymphedema. Lymphology. 1978;11(4):174-80.PubMedGoogle Scholar
Olszewski WL, Jamal S, Lukomska B, Manokaran G, Grzelak I. Immune proteins in peripheral tissue fluid-lymph in patients with filarial lymphedema of the lower limbs. Lymphology. 1992;25(4):166-71.PubMedGoogle Scholar
Olszewski WL, Pazdur J, Kubasiewicz E, Zaleska M, Cooke CJ, Miller NE. Lymph draining from foot joints in rheumatoid arthritis provides insight into local cytokine and chemokine production and transport to lymph nodes. Arthritis Rheum. 2001;44(3):541-9.PubMedCrossRefGoogle Scholar
Olszewski WL. Pathophysiological aspects of lymphedema of human limbs: I Lymph protein composition. Lymphat Res Biol. 2003;1(3):235-43.PubMedCrossRefGoogle Scholar
Olszewski WL, Jain P, Ambujam G, Zaleska M, Cakala M. Cytokines in various types of lower limb lymphedema. J Clin Invest 2010 (submitted).Google Scholar