Biological Causes of Anterior Knee Pain

  • Vicente Sanchis-Alfonso
  • Esther Roselló-Sastre
  • Juan Saus-Mas
  • Fernando Revert-Ros


Despite an abundance of clinical and basic science research, anterior knee pain syndrome or patellofemoral pain syndrome (PFPS) remains, according to John Insall, an orthopedic “enigma” (“Black hole of Ortho­pedics”). The numerous treatment regimes that exist for PFPS highlight the lack of knowledge regarding the etiology of the pain. At present, no theory provides a comprehensive explanation of the true nature of this pathologic condition or how to hasten its resolution in a safe and reliable way. This chapter reviews the literature and synthesizes our research on anterior knee pain pathophysiology. This topic is clinically relevant because patient management will be greatly simplified when we understand what the causes are for anterior knee pain in the young patient.


Vascular Endothelial Growth Factor Anterior Knee Pain Osteoid Osteoma Patellar Instability Free Nerve Ending 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Vicente Sanchis-Alfonso
    • 1
  • Esther Roselló-Sastre
  • Juan Saus-Mas
  • Fernando Revert-Ros
  1. 1.International Patellofemoral Study Group, International ACL Study Group, Hospital 9 de Octubre, Hospital Arnau de Vilanova, School of MedicineCatholic University of ValenciaValenciaSpain

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