Biochemical Causes of Patellar Tendinopathy?



During recent years, increasing attention has been devoted to the biochemical milieu of human tendons. Prompted by the lack of evident causality in the aetiology of tendinopathy, much contemporary research is focused on the possible roles of biochemical agents in the development of tendon symptoms and tissue changes. Although further experiments testing the functional importance of such biochemical mediators in tendinopathy are greatly needed, evidence of a dramatic metamorphosis in local cell signalling within chronically painful tendons exists. The evidence for biochemical aspects of tendinopathy that has consequently emerged might complement, rather than replace, existing theories on pathogenesis (see Chap. 15). It furthermore fits a theoretical model in which tendon pathology exists on a continuum which, at various points, involves abnormalities in blood vessels, nerves, tenocytes, and extracellular matrix.14 The aim of this chapter is to present the evidence that supports this biochemical model of patellar tendinopathy.


Patellar Tendon Tendon Tissue Patellar Tendinopathy Tendon Pathology Nerve Terminals21 
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© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Department of Integrative Medical Biology, Section for Anatomy, Faculty of MedicineUmeå UniversityUmeåSweden

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