Surgical Site Infection Prophylaxis



Surgical site infection (SSI) is one of the most common hospital-acquired infections, occurring in up to 5% of clean extra-abdominal surgeries and in up to 20% of intraabdominal surgeries.1 It is defined as an infection at the site of surgery that occurs within 30 days after surgery or within 1 year if a foreign body was implanted during surgery. Although there are a number of patient-specific risk factors, the type of surgery is the primary risk factor and determines the need for prophylactic antibiotics. This chapter reviews the risk factors and recommendations for antibiotic prophylaxis to reduce SSI. Other prophylactic measures to prevent endocarditis, pneumonia, and aspiration are covered elsewhere.


Surgical Site Infection Antibiotic Prophylaxis Prophylactic Antibiotic Primary Risk Factor Chlorhexidine Gluconate 
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  1. 1.
    Bratzler DW, Hunt DR. The surgical infection prevention and surgical care improvement ­projects: national initiatives to improve outcomes for patients having surgery. Clin Infect Dis. 2006;43(3):322-330; Epub 2006 Jun 16. PMID: 16804848.PubMedCrossRefGoogle Scholar
  2. 2.
    Mangram AJ, Horan TC, Pearson ML, et al. Guideline for prevention of surgical site infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee. Am J Infect Control. 1999;27(2):97-132; quiz 133-134; discussion 96. PMID: 10196487.PubMedCrossRefGoogle Scholar
  3. 3.
    Tanner J, Swarbrook S, Stuart J. Surgical hand antisepsis to reduce surgical site infection. Cochrane Database Syst Rev. 2008;(1):CD004288.Google Scholar
  4. 4.
    Bratzler DW, Houck PM. Surgical infection prevention guidelines writers workgroup. Antimicrobial prophylaxis for surgery: an advisory statement from the national surgical infection prevention project. Clin Infect Dis. 2004;38(12):1706-1715; Epub 2004 May 26. PMID: 15227616.PubMedCrossRefGoogle Scholar
  5. 5.
  6. 6.
    Bratzler DW, Ma A, Nsa W. Surgical care improvement project adherence and postoperative infections. JAMA. 2010;304(15):1670; author reply 1671-1672. PMID: 20959574.PubMedCrossRefGoogle Scholar
  7. 7.
    Antimicrobial prophylaxis for surgery. Treat Guidel Med Lett. 2009;7(82):47-52.Google Scholar
  8. 8.
    Engelman R, Shahian D, Shemin R, et al. The Society of Thoracic Surgeons practice guideline series: antibiotic prophylaxis in cardiac surgery, part II: antibiotic choice. Ann Thorac Surg. 2007;83(4):1569-1576.PubMedCrossRefGoogle Scholar
  9. 9.
    Weber WP, Marti WR, Zwahlen M, et al. The timing of surgical antimicrobial prophylaxis. Ann Surg. 2008;247(6):918-926. PMID: 18520217.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.UCI Medical Center, UCI Hospitalist ProgramUniversity of California, Irvine, College of MedicineOrangeUSA

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