Abstract
Most of renal tumors occur in adults; however they could also be seen in children but with less frequency. The same applies to renal tumors in children can also occur in adults but are less common.
In this chapter we are mainly concentrating on renal tumors in adults. The classification of renal tumors will be discussed, dividing them into benign and malignant.
The majority of these tumors are carcinomas; however there are different histological types with different prognostic outcome. Therefore the different histological types of these cancers will be addressed especially in relation to their biological behavior.
Benign tumors including oncocytoma, adenomas and angiomyolipomas will also be addressed. The importance of these tumors will be discussed especially in relation to how to differentiate them from malignant lesions, from both the radiological and pathological points of view.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aydin H, Zhou M. The changing face of renal cell carcinoma pathology. Curr Oncol Rep. 2008;10(3):235–44.
Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol. 2010;7(5):277–85.
Moch H, Gasser T, Amin MB, et al. Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors. Cancer. 2000;89:604–14.
Algabaa F, Akazab H, Lo’pez-Beltra’nc A, et al. Current pathology keys of renal cell carcinoma. Eur Urol. 2011;60:634–43.
Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z. Review – kidney cancer: 2004 WHO classification of the renal tumors of the adults. Eur Urol. 2006;49:798–805.
Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003;27:612–24.
Eble JN, Sauter G, Epstein JI, Sesterhenn IA. World Health Organisation classification of tumours. In: Pathology and genetic tumours of the urinary system and male genital organs. Lyon: IARC Press; 2004. p. 10.
Argani P, Netto GJ, Parwani AV. Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma. Am J Surg Pathol. 2008;32:1353–9.
Hes O, Brunelli M, Michal M, et al. Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural and interphase cytogenetic study of 12 cases. Ann Diagn Pathol. 2006;10:133–9.
Mai KT, Kohler DM, Robertson SJ, et al. Oncocytic papillary renal cell carcinoma with solid architecture: mimic of renal oncocytomas. Pathol Int. 2008;58(3):164–8.
Rumpelt HJ, Storkel S, Moll R, et al. Bellini duct carcinoma: further evidence for this rare variant of renal cell carcinoma. Histopathology. 1991;18:115–22.
Srigley JR, Delahunt B. Uncommon and recently described renal carcinomas. Mod Pathol. 2009;22:S2–23.
Gregori-Romero MA, Morell-Quadreny L, Llombart-Bosch A. Cytogenetic analysis of three primary Bellini duct carcinomas. Genes Chromosomes Cancer. 1996;15:170–2.
Shanbhogue AK, Vikram R, Paspulati RM, et al. Rare (<1%) histological subtypes of renal cell carcinoma. An update. Abdom Imaging. 2012;37:861–72.
Baig MA, Lin YS, Rasheed J, Mittman N. Renal medullary carcinoma. J Natl Med Assoc. 2006;98:1171–4.
Camparo P, Vasiliu V, Molinie V, et al. Renal translocation carcinomas-clinicopathologic, immunohistochemical and gene expression profiling analysis of 31 cases with a review of the literature. Am J Surg Pathol. 2008;35:656–70.
Argani P, Lal P, Hutchinson B, et al. Aberrant nuclear immunoreactivity for TFE3 in neoplasmswith TFE3 gene fusions: a sensitive and specific immuno histochemical assay. Am J Surg Pathol. 2003;27:750–61.
Bassal M, Mertens AC, Taylor L, et al. Risk of selected subsequent carcinomas in survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol. 2006;24:476–83.
Cossu-Rocca P, Eble JN, Delahunt B, et al. Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 2006;19:488–93.
Rakozy C, Schmahl GE, Bogner S, Storkel S. Low-grade tubular-mucinous renal neoplasms: morphologic, immunohistochemical, and genetic features. Mod Pathol. 2002;15:1162–71.
Ferlicot S, Allory Y, Comperat E, et al. Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature. Virchows Arch. 2005;447:978–83.
Coleman JA. Familial and hereditary renal cancer syndromes. Urol Clin North Am. 2008;35:563–72.
MacLennan GT, Cheng L. Tubulocystic carcinoma of the kidney. J Urol. 2011;185:2348–9.
Terenziani M, Spreafico F, Collini P, Piva L, et al. Adult Wilms’ tumor: a monoinstitutional experience anda review of the literature. Cancer. 2004;101:289–93.
Reinhard H, Aliani S, Ruebe C, et al. Wilms’ tumor in adults: results of the society of paediatric oncology (SIOP) 93-01/Society for paediatric oncology and haematology (GPOH) study. J Clin Oncol. 2004;22(22):4500–6.
Kilton L, Mathews MJ, Cohen MH. Adult Wilms’ tumor: a report of prolonged survival and review of literature. J Urol. 1980;124:1–5.
Kuroda N, Toi M, Hiroi M, et al. Review of renal oncocytoma with focus on clinical and pathobiological aspects. Histol Histopathol. 2003;18(3):935–42.
Sherman JL, Hartman DS, Friedman AC, Madewell JE, et al. Angiomyolipoma: computed tomographic-pathologic correlation of 17 cases. AJR Am J Roentgenol. 1981;137:1221–6.
Jinzaki M, Tanimoto A, Narimatsu Y, et al. Angiomyolipoma: imaging findings in lesions with minimal fat. Radiology. 1997;205:497–502.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag London
About this chapter
Cite this chapter
Lee, A., Baithun, S.I. (2015). Pathology of Renal Cancer. In: Nargund, V., Raghavan, D., Sandler, H. (eds) Urological Oncology. Springer, London. https://doi.org/10.1007/978-0-85729-482-1_19
Download citation
DOI: https://doi.org/10.1007/978-0-85729-482-1_19
Published:
Publisher Name: Springer, London
Print ISBN: 978-0-85729-481-4
Online ISBN: 978-0-85729-482-1
eBook Packages: MedicineMedicine (R0)