Substance Prioritisation for the Development of EU Acute Exposure Toxicity Thresholds: Risk-Informed Decision Making

  • Mary Trainor
  • Ron Macbeth
  • Peter Ridgway
Conference paper


The aim of the EU ACUTEX project is to develop a methodology for establishing European Acute Exposure Threshold Levels (EU AETLs) for toxic substances in relation to harm to people by inhalation. Their development is initially in the context of the EU’ seveso II’ Directive through which the risks of major accidents from chemical sites are regulated. This paper describes the prioritisation of 21 substances for AETL case studies based on an EU stakeholder consultation exercise. It also outlines progress on the subsequent development of a prioritisation methodology to inform initial substance selection for a possible further AETLs programme.


Competent Authority Risk Governance Priority Substance Major Accident Chemical Site 
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  1. 1.
    European Communities. Commission. Report on the Application in the Member States of Directive 82/501/EEC. O.J. European Communities 31.1.2002; C 28: 1-48Google Scholar
  2. 2.
    Council Directive 96/82/EC of 9 December 1996 on the Control of Major Accident Hazards Involving Dangerous Substances. O.J. European Communities 14.1.1997; L 10: 13-33Google Scholar
  3. 3.
    Gottschall C. Establishing Acute Exposure Guideline Levels. Chemical Health and Safety 1997; 4(2): 38–41Google Scholar
  4. 4.
    OECD. Existing Chemicals: Systematic Investigation, Priority Setting and Chemicals Review. OECD Paris, 1986Google Scholar
  5. 5.
    Swanson M. and Socha A. (eds.) Chemical Ranking and Scoring: Guidelines for Relative Assessments of Chemicals. SETAC Florida, 1997Google Scholar
  6. 6.
    Trainor M. et al. Substance Prioritisation for the EU ACUTEX Project’s 21 Acute Exposure Threshold Level Case Studies, HSL Report RAS/03/17. HSE Information Centre, Broad Lane, Sheffield S3 7ZL, UK, 2003Google Scholar
  7. 7.
    European Communities. Commission. White Paper on Risk Governance. Series COM(2001)428 Final. Brussels, 2001Google Scholar
  8. 8.
    Otway H. and Peltu M. Regulating Industrial Risks: Science, Hazards and Public Protection. Butterworth London, 1985Google Scholar
  9. 9.
    Christou M.D. Amendola A. and Smeder M. The Control of Major Accident Hazards: The Land-Use Planning Issue. J. Haz. Mat. 1999; 65: 151–178CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2004

Authors and Affiliations

  • Mary Trainor
    • 1
  • Ron Macbeth
    • 1
  • Peter Ridgway
    • 2
  1. 1.Helen Balmforth Health & Safety LaboratorySheffieldUK
  2. 2.Health & Safety ExecutiveBootleUK

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