Physiology of Calcium Homeostasis and Bone Remodeling
Calcium homeostasis is dependent on three major organs (intestine, kidney, bone) and three major hormones: parathyroid hormone (PTH), 1,25-(OH)2-D3, and calcitonin.
Bone composition is complex and contains matrix with minerals and proteins (collagen and others).
Bone is continuously turned over by osteoclasts and osteoblasts, during growth by modeling and during adulthood by remodeling.
The receptor activator for the nuclear factor KB (RANK) ligand and its decoy receptor osteoprotegerin (OPG) are key regulatory factors of bone resorption produced by osteoblastic stromal cells, which respectively stimulate and inhibit osteoclast differentiation via interaction with the RANK receptor of osteoclast precursors.
KeywordsBone Resorption Osteoclast Precursor Plasma Calcium Central Pool Calciotropic Hormone
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