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Reviewing the Literature, Developing a Hypothesis, Study Design

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Success in Academic Surgery

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Abstract

Rigorous research investigation requires a thorough review of the literature on the topic of interest. This promotes development of an original, relevant, and feasible hypothesis. Design of an optimal study to test the hypothesis then requires adequate power, freedom from bias, and conduct within a reasonable timeframe with resources available to the investigator.

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Selected Readings

  1. Friedman LM, Furberg CD, DeMets DL. Fundamentals of Clinical Trials. 4th ed. New York: Springer; 1998.

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  3. Penson DF, Wei J. Clinical Research Methods for Surgeons. Totowa: Humana Press; 2006.

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  4. Piantadosi S. Clinical Trials: A Methodological Perspective. 2nd ed. New York: Wiley; 2005.

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Acknowledgments

Financial Support: Indiana Genomics Initiative (INGEN) of Indiana University. INGEN is supported in part by Lilly Endowment Inc. (CMS).

I would like to thank Dr. Carl Schmidt, MD, MSCI, Assistant Professor Surgery, the Ohio State University, for his expertise and critical review of this chapter.

Author information

Authors and Affiliations

  1. Department of Surgery, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    C. Max Schmidt M.D., Ph.D., MBA

Authors
  1. C. Max Schmidt M.D., Ph.D., MBA
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Editors and Affiliations

  1. Dept. Surgery, H4/750 Clinical Science Center, University of Wisconsin Medical School, Highland Avenue 600, MADISON, 53792, Wisconsin, USA

    Herbert Chen

  2. , Department of Surgery, The University of Texas Health Science C, Houston, 77026, Texas, USA

    Lillian S. Kao

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© 2011 Springer-Verlag London Limited

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Schmidt, C.M. (2011). Reviewing the Literature, Developing a Hypothesis, Study Design. In: Chen, H., Kao, L. (eds) Success in Academic Surgery. Springer, London. https://doi.org/10.1007/978-0-85729-313-8_3

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  • DOI: https://doi.org/10.1007/978-0-85729-313-8_3

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  • Publisher Name: Springer, London

  • Print ISBN: 978-0-85729-312-1

  • Online ISBN: 978-0-85729-313-8

  • eBook Packages: MedicineMedicine (R0)

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