Methods in Bone Biology: Cancer and Bone



Metastasis of cancer to bone is one of the most significant causes of morbidity and often indicates poor prognosis particularly for breast cancer, prostate cancer, and lung cancer patients. Animal models are important tools to investigate the pathogenesis of, and develop novel treatment strategies for, bone metastases in humans. The ideal animal model of bone metastatic human cancer would reproduce the genetic and phenotypic changes that occur with human cancers.


Bone Metastasis Bone Microenvironment Contralateral Tibia Ideal Animal Model Phosphate Buffer Saline Control 
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The authors would like to thank Dr Marcus Neudert and Professor Frieder Bauss, Germany, for their assistance with the description of the intra-arterial rat model. This work has been supported by the following research grants: Prostate Cancer Foundation of Australia (PCFA) (M.J.S, Y.Z, H.Z), University of Sydney Cancer Research Fund (M.J.S), and National Health and Medical Research Council, Australia (NHMRC) (M.J.S, H.Z.). Y.Z receives support from the National Health & Medical Research Council Australia, Training Fellowship.


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© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Bone Research Program, ANZAC Research InstituteUniversity of SydneyConcordAustralia

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