Methods in Bone Histomorphometry for Animal Models

  • Natalie Dion
  • Audray Fortin
  • Louis-Georges Ste-Marie


Animal models are essential for preclinical skeletal research, notably in the study of physiopathology of metabolic bone diseases as well as in the evaluation of a test agent for the prevention and treatment of bone diseases such as osteoporosis. However, rat or mouse models do not completely reflect human bone disorders and therapeutic responses, but they provide insight into the understanding of bone pathologies and their treatments.


Bone Turnover Trabecular Bone Peak Bone Mass Tartrate Resistant Acid Phosphatase Bone Modeling 



We are grateful to Claire Deschênes for her excellent technical assistance.


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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Natalie Dion
  • Audray Fortin
  • Louis-Georges Ste-Marie
    • 1
  1. 1.Laboratory of Metabolic Bone DiseasesCRCHUM – Hôpital Saint-LucMontréalCanada

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