Methods in Bone Histomorphometry for Animal Models
Animal models are essential for preclinical skeletal research, notably in the study of physiopathology of metabolic bone diseases as well as in the evaluation of a test agent for the prevention and treatment of bone diseases such as osteoporosis. However, rat or mouse models do not completely reflect human bone disorders and therapeutic responses, but they provide insight into the understanding of bone pathologies and their treatments.
KeywordsBone Turnover Trabecular Bone Peak Bone Mass Tartrate Resistant Acid Phosphatase Bone Modeling
We are grateful to Claire Deschênes for her excellent technical assistance.
- 6.Li M, Jee WSS. Models of predlinical skeletal research. ICHTS-CSBME 2nd APBM workshop on bone histomorphometry and imaging Beijng, China; 2008:14-15.Google Scholar
- 11.Hall D. The Methodology of Connective Tissue Research. Oxford: Joynson-Bruvvers; 1976:130.Google Scholar
- 13.Frost HM. Bone hostomorphometry: correction of labeling “escape error”. In: Recker RR, ed. Bone Histomorphometry: Techniques and Interpretation. Boca Raton: CRC; 1983:133-142.Google Scholar