Skeletal Phenotyping in Rodents: Tissue Isolation and Manipulation



The pioneering work of Rudolph Jaenisch at the Whitehead Institute1 and Mario Capecchi at the Howard Hughes Institute2 used modification of the mouse genome to understand the etiology and pathogenesis of human disease.


Bone Mineral Density Bone Strength Bone Regeneration Tartrate Resistant Acid Phosphatase Allograft Bone 



This work was supported in part by grants from the Canadian Institutes of Health Research, Genome Québec, the Fonds de la recherche en sante Quebec sponsored Réseau de recherché en transgenèse du Québec, and the Réseau de recherche en santé buccodentaire et osseuse. Dr. C. Gao is a scholar of the MENTOR Strategic Training in Health Research program. The authors thank Ailian Li, Wei Li, and Huifen Wang for their invaluable assistance with the mouse phenotyping work and Dr. J. Seuntjens of the Medical Physics Unit, McGill University, for collaboration with the mouse irradiation studies.


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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  • Janet E. Henderson
    • 1
  • Chan Gao
  • Edward J. Harvey
  1. 1.Department of Medicine and SurgeryMcGill University Health Centre, Montreal General HospitalMontrealCanada

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