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Classical Models of Senile Osteoporosis

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Osteoporosis Research

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Abstract

Most vertebrates exhibit age-related decline in physiological function, particularly in locomotion. Loss of muscle volume and bone mass in late life is a hallmark of aging and resembles tissue obsolescence caused by disuse. However, some human populations lose bone mass more rapidly than would be predicted by normal aging. These individuals are diagnosed as having senile osteoporosis, one of the most prevalent geriatric disorders and one that seriously decreases quality of life in the elderly. As noted throughout this book, mice and rats are the most frequently used models to study osteoporosis, its treatment and prevention, and concomitant pathogenesis. Both mice and rats have an approximately 3-year lifespan. Bone mass peaks within the first quarter of life and then declines with age. This chapter describes age-related bone loss in laboratory rodents.

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Authors and Affiliations

  1. Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

    Ken Watanabe

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Correspondence to Ken Watanabe .

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  1. Nepean Hospital, Dept. Geriatric Medicine, University of Sydney, Penrith, 2750, New South Wales, Australia

    Gustavo Duque

  2. Department of Bone & Joint Disease, National Center for Geriatrics & Geronto, Obu-Aichi, Japan

    Ken Watanabe

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Watanabe, K. (2011). Classical Models of Senile Osteoporosis. In: Duque, G., Watanabe, K. (eds) Osteoporosis Research. Springer, London. https://doi.org/10.1007/978-0-85729-293-3_10

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  • DOI: https://doi.org/10.1007/978-0-85729-293-3_10

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