Classical Models of Senile Osteoporosis



Most vertebrates exhibit age-related decline in physiological function, particularly in locomotion. Loss of muscle volume and bone mass in late life is a hallmark of aging and resembles tissue obsolescence caused by disuse. However, some human populations lose bone mass more rapidly than would be predicted by normal aging. These individuals are diagnosed as having senile osteoporosis, one of the most prevalent geriatric disorders and one that seriously decreases quality of life in the elderly. As noted throughout this book, mice and rats are the most frequently used models to study osteoporosis, its treatment and prevention, and concomitant pathogenesis. Both mice and rats have an approximately 3-year lifespan. Bone mass peaks within the first quarter of life and then declines with age. This chapter describes age-related bone loss in laboratory rodents.


Bone Mineral Density Bone Mass Caloric Restriction Osteoclast Formation Trabecular Bone Volume 
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Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Department of Bone and Joint DiseaseNational Center for Geriatrics and GerontologyObuJapan

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