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Photodynamic Therapy

  • Robert Bissonnette
Chapter

Abstract

Photodynamic therapy with ALA or MAL is an excellent treatment for multiple actinic keratoses

Large field photodynamic therapy can eradicate multiple actinic keratoses with a shorter downtime than 5-fluorouracil or imiquimod

Multiple large field photodynamic therapy sessions can delay the appearance of actinic keratoses

Keywords

Basal Cell Carcinoma Sebaceous Gland Actinic Keratose Intense Pulse Light Hidradenitis Suppurativa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1.  1.
    Taub AF. Photodynamic therapy for the treatment of acne: a pilot study. J Drugs Dermatol. 2004;3(6 Suppl):S10-S14.PubMedGoogle Scholar
  2.  2.
    Kennedy JC, Pottier RH, Pross DC. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B. 1990;6(1–2):143-148.PubMedCrossRefGoogle Scholar
  3.  3.
    Kloek J, Akkermans W, van Beijersbergen Henegouwen GM. Derivatives of 5-aminolevulinic acid for photodynamic therapy: enzymatic conversion into protoporphyrin. Photochem Photobiol. 1998;67(1):150-154.PubMedCrossRefGoogle Scholar
  4.  4.
    Piacquadio DJ, Chen DM, Farber HF, et al. Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials. Arch Dermatol. 2004;140(1):41-46.PubMedCrossRefGoogle Scholar
  5.  5.
    Touma D, Yaar M, Whitehead S, et al. A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol. 2004;140(1):33-40.PubMedCrossRefGoogle Scholar
  6.  6.
    Wang I, Bendsoe N, Klinteberg CA, et al. Photodynamic therapy vs. cryosurgery of basal cell carcinomas: results of a phase III clinical trial. Br J Dermatol. 2001;144(4):832-840.PubMedCrossRefGoogle Scholar
  7.  7.
    Pariser DM, Lowe NJ, Stewart DM, et al. Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol. 2003;48(2):227-232.PubMedCrossRefGoogle Scholar
  8.  8.
    Tarstedt M, Rosdahl I, Berne B, et al. A randomized multicenter study to compare two treatment regimes of topical methyl aminolevulinate (Metvix)-PDT in actinic keratosis of the face and scalp. Acta Derm Venereol. 2005;85:424-428.PubMedCrossRefGoogle Scholar
  9.  9.
    Horn M, Wolf P, Wulf HC, et al. Topical methyl aminolaevulinate photodynamic therapy in patients with basal cell carcinoma prone to complications and poor cosmetic outcome with conventional treatment. Br J Dermatol. 2003;149(6):1242-1249.PubMedCrossRefGoogle Scholar
  10. 10.
    Rhodes LE, de Rie M, Enstrom Y, et al. Photodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial. Arch Dermatol. 2004;140(1):17-23.PubMedCrossRefGoogle Scholar
  11. 11.
    Vinciullo C, Elliott T, Francis D, et al. Photodynamic therapy with topical methyl aminolaevulinate for ‘difficult-to-treat’ basal cell carcinoma. Br J Dermatol. 2005;152(4):765-772.PubMedCrossRefGoogle Scholar
  12. 12.
    Basset-Seguin N, Ibbotson SH, Emtestam L, et al. MAL-PDT versus cryotherapy in primary sBCC: results of 48-month follow up. J Eur Acad Dermatol Venereol. 2005;19(Suppl 2):237.Google Scholar
  13. 13.
    Basset-Seguin N, Ibbotson SH, Emtestam L, et al. MAL-PDT versus cryotherapy in primary sBCC: results of 36 months follow-up. J Eur Acad Dermatol Venereol. 2004;18(Suppl 2):412.Google Scholar
  14. 14.
    Alexiades-Armenakas M. Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. J Drugs Dermatol. 2006;5(1):45-55.PubMedGoogle Scholar
  15. 15.
    Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial. Br J Dermatol. 2006;154(5):969-976.PubMedCrossRefGoogle Scholar
  16. 16.
    Gold M, Bridges TM, Bradshaw VL, et al. ALA-PDT and blue light therapy for hidradenitis suppurativa. J Drugs Dermatol. 2004;3(1 Suppl):S32-S35.PubMedGoogle Scholar
  17. 17.
    Dover JS, Bhatia AC, Stewart B, et al. Topical 5-aminolevulinic acid combined with intense pulsed light in the treatment of photoaging. Arch Dermatol. 2005;141(10):1247-1252.PubMedCrossRefGoogle Scholar
  18. 18.
    Alster TS, Tanzi EL, Welsh EC. Photorejuvenation of facial skin with topical 20% 5-aminolevulinic acid and intense pulsed light treatment: a split-face comparison study. J Drugs Dermatol. 2005;4(1):35-38.PubMedGoogle Scholar
  19. 19.
    Alster TS, Tanzi EL. Photodynamic therapy with topical aminolevulinic acid and pulsed dye laser irradiation for sebaceous hyperplasia. J Drugs Dermatol. 2003;2(5):501-504.PubMedGoogle Scholar
  20. 20.
    Horfelt C, Funk J, Frohm-Nilsson M, et al. Topical methyl aminolaevulinate photodynamic therapy for treatment of facial acne vulgaris: results of a randomized, controlled study. Br J Dermatol. 2006;155(3):608-613.PubMedCrossRefGoogle Scholar
  21. 21.
    Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol. 2006;54(4):647-651.PubMedCrossRefGoogle Scholar
  22. 22.
    Hongcharu W, Taylor CR, Chang Y, et al. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Investig Dermatol. 2000;115(2):183-192.PubMedCrossRefGoogle Scholar
  23. 23.
    Borelli C, Merk K, Schaller M, et al. In vivo porphyrin production by P. acnes in untreated acne patients and its modulation by acne treatment. Acta Derm Venereol. 2006;86(4):316-319.PubMedCrossRefGoogle Scholar
  24. 24.
    Avram DK, Goldman MP. Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage. J Drugs Dermatol. 2004;3(1 Suppl):S36-S39.PubMedGoogle Scholar
  25. 25.
    Gold MH, Bradshaw VL, Boring MM, et al. Split-face comparison of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone for photodamage. Dermatol Surg. 2006;32(6):795-801. Discussion 801-803.PubMedCrossRefGoogle Scholar
  26. 26.
    Brooke RC, Sinha A, Sidhu MK, et al. Histamine is released following aminolevulinic acid-photodynamic therapy of human skin and mediates an aminolevulinic acid dose-related immediate inflammatory response. J Invest Dermatol. 2006;126(10):2296-2301.PubMedCrossRefGoogle Scholar
  27. 27.
    Katz BE, Truong S, Maiwald DC, et al. Efficacy of microdermabrasion preceding ALA application in reducing the incubation time of ALA in laser PDT. J Drugs Dermatol. 2007;6(2):140-142.PubMedGoogle Scholar
  28. 28.
    Bissonnette R, Nigen S, Bolduc C, et al. Protection afforded by sunscreens containing inorganic sunscreening agents against blue light sensitivity induced by aminolevulinic acid. Dermatol Surg. 2008;34(11):1469-1476.PubMedCrossRefGoogle Scholar
  29. 29.
    Goldman MP, Merial-Kieny C, Nocera T, et al. Comparative benefit of two thermal spring waters after photodynamic therapy procedure. J Cosmet Dermatol. 2007;6(1):31-35.PubMedCrossRefGoogle Scholar
  30. 30.
    Misra A, Maybury K, Eltigani TA. Late erythema after photodynamic therapy to the face. Plast Reconstr Surg. 2006;117(7):2522-2523.PubMedCrossRefGoogle Scholar
  31. 31.
    Harries MJ, Street G, Gilmour E, et al. Allergic contact dermatitis to methyl aminolevulinate (Metvix) cream used in photodynamic therapy. Photodermatol Photoimmunol Photomed. 2007;23(1):35-36.PubMedCrossRefGoogle Scholar
  32. 32.
    Angell-Petersen E, Christensen C, Muller CR, et al. Phototoxic reaction and porphyrin fluorescence in skin after topical application of methyl aminolaevulinate. Br J Dermatol. 2007;156(2):301-307.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2011

Authors and Affiliations

  1. 1.Innovaderm Research Inc.Montreal, QuebecCanada

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