An Update on Face Transplants Performed Between 2005 and 2010

  • Maria Z. SiemionowEmail author
  • Can Ozturk
  • Selman Altuntas


Background: Since 2005, 13 facial allotransplantation cases were performed throughout the world. The major indications for facial allotransplantations were neurofibromatosis and trauma injuries including animal bites, burns, falls, and shotgun blasts. The ratio of male to female was 11:2. Two male patients died at 2 months and 2 years after transplantation due to transplant-related problems. The composite tissue allotransplantations included cutaneous, myocutaneous, and osteomyocutaneous components and functional units of nose, eyelids and lips. Most of these were partial, a few near-total, and two were announced as total face transplantations. The analysis of the anatomical details, microsurgical techniques, and the functional outcomes of all cases with follow-up information from literature, meeting presentations and media reports is presented in this chapter.


Facial Nerve Motor Recovery Nerve Repair Mental Foramen Facial Artery 
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  1. 1.
    Lee WP, Butler PE. Transplant biology and applications to plastic surgery. In: Aston SJ, Beasley RW, Thorne CHM, eds. Grabb and Smith’s Plastic Surgery. Philadelphia: Lippincott-Raven; 1997.Google Scholar
  2. 2.
    Malt RA, McKhann C. Replantation of several arms. JAMA. 1964;189:716-722.PubMedGoogle Scholar
  3. 3.
    Dubernard JM, Owen E, Herzberg G, et al. Human hand allograft: report on first 6 months. Lancet. 1999;353:1315-1320.PubMedCrossRefGoogle Scholar
  4. 4.
    International registry on hand and composite tissue transplantation.
  5. 5.
    Dubernard JM, Lengele B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med. 2007;357:2451-2460.PubMedCrossRefGoogle Scholar
  6. 6.
    Guo S, Han Y, Zhang X, et al. Human facial allotransplantation: a 2-year follow-up study. Lancet. 2008;372:631-638.PubMedCrossRefGoogle Scholar
  7. 7.
    Lantieri L, Meningaud JP, Grimbert P, et al. Repair of the lower and middle parts of the face by composite tissue allotransplantation in a patient with massive plexiform neurofibroma: a 1-year follow-up study. Lancet. 2008;372:639-645.PubMedCrossRefGoogle Scholar
  8. 8.
    Siemionow M, Papay F, Djohan R, et al. First U.S. near-total human face transplantation – a paradigm shift for massive facial injuries. Plast Reconstr Surg. 2010;125:111-122.PubMedGoogle Scholar
  9. 9.
    Siemionow M, Papay F, Alam D, et al. Near-total human face transplantation for a severely disfigured patient in the USA. Lancet. 2009;374:203-209.PubMedCrossRefGoogle Scholar
  10. 10.
    Pomahac B, Lengele B, Ridgway EB, et al. Vascular considerations in composite midfacial allotransplantation. Plast Reconstr Surg. 2010;125:517-522.PubMedCrossRefGoogle Scholar
  11. 11.
    Meningaud JP, Benjoar MD, Hivelin M et al. The procurement of total human face graft for allotransplantation: a preclinical study and the first clinical case. Plast Reconstr Surg 2010 June 15 [ePub ahead of print].Google Scholar
  12. 12.
    Spain’s first face transplant patient smiling. Usa Today. Accessed August 22, 2009.
  13. 13.
    Spain’s second face transplanted completed in Sevilla. Spain news. Accessed January 27, 2010.
  14. 14.
    World’s First Full Face Transplant A Success Say Spanish Doctors. Medical news today. Accessed April 26, 2010.
  15. 15.
    Gordon CR, Siemionow M, Papay F, et al. The world’s experience with facial transplantation: what have we learned thus far? Ann Plast Surg. 2009;63:572-578.PubMedCrossRefGoogle Scholar
  16. 16.
    Doctors perform face transplant with eyelids. Msnbc.
  17. 17.
    Devauchelle B. Microsurgical reconstruction of the face: Some outstanding indications. In Proceedings of the 7th Congress of Polish Society of Oral and Craniofacial Surgery, Jachranka, Poland. 2010;14-15.Google Scholar
  18. 18.
    Lantieri L, Grimbert P, Meningaud JP, Bellivier F. Face transplantation outcomes: Feasibility, reproducibility and efficacy. Paper presented at: 21st Annual Meeting of The European Association of Plastic Surgeons; Manchester, UK. 2010;27-30.Google Scholar
  19. 19.
    Eaton L. Spanish doctors carry out first transplantation of a full face. BMJ. 2010;340:c2303.PubMedCrossRefGoogle Scholar
  20. 20.
    Eaton L. First patient to receive complete face transplant can leave hospital. BMJ. 2010;341:c4088.PubMedCrossRefGoogle Scholar
  21. 21.
    Perez RH, Lopez P, Escoresca-Ortega A.M, et al. Severe rhabdomyolysis after allogeneic transplantation of facial structures: A case report. Transplant Proc. 2010;42(8): 3081-3082.Google Scholar
  22. 22.
    Barret J. Composite facial allotransplantation: The Barcelona full face transplant. In Proceedings of the Advanced Educational Courses in Plastic Surgery Meeting of British Association of Plastic, Reconstructive and Aesthetic Surgeons, Manchester, UK. 2010;1-2.Google Scholar
  23. 23.
    Hivelin M. Face transplantation outcomes: Report on the Mondor series. In Proceedings of the Advanced Educational Courses in Plastic Surgery Meeting of British Association of Plastic, Reconstructive and Aesthetic Surgeons, Manchester, UK. 2010;1-2.Google Scholar
  24. 24.
    Morelon E, Testelin S, Petruzzo P, et al. New partial face allograft transplantation: Report on first six months. Paper presented at: 2010 American Society for Reconstructive Transplantation 2nd Biennial Meeting; Chicago, Ill. 2010;18-20.Google Scholar
  25. 25.
    Pedro Cavadas. Clinical Update & Update on Hand and Face Transplant Outcomes. In Proceedings of the 2010 American Society for Reconstructive Transplantation 2nd Biennial Meeting, Chicago, Ill. 2010;18-20.Google Scholar
  26. 26.
    Hui-Chou HG, Nam AJ, Rodriguez ED. Clinical facial composite tissue allotransplantation: a review of the first four global experiences and future implications (Review). Plast Reconstr Surg. 2010;125:538-546.PubMedCrossRefGoogle Scholar
  27. 27.
    Takamatsu A, Harashina T, Inoue T. Selection of appropriate recipient vessels in difficult, microsurgical head and neck reconstruction. J Reconstr Microsurg. 1996;12:499-507; Discussion 508-513.PubMedCrossRefGoogle Scholar
  28. 28.
    Wilhelmi BJ, Kang RH, Movassaghi K, Ganchi PA, et al. First successful replantation of face and scalp with single artery repair: model for face and scalp transplantation. Ann Plast Surg. 2003;50:535-540.PubMedCrossRefGoogle Scholar
  29. 29.
    Yin JW, Matsuo JM, Hsieh CH, et al. Replantation of total avulsed scalp with microsurgery: experience of eight cases and literature review. J Trauma. 2008;64:796-802.PubMedCrossRefGoogle Scholar
  30. 30.
    Tohma A, Mine K, Tamatsu Y, et al. Communication between the buccal nerve (V) and facial nerve (VII) in the human face. Ann Anat. 2004;186:173-178.PubMedCrossRefGoogle Scholar
  31. 31.
    Baumel JJ. Trigeminal-facial nerve communications. Their function in facial muscle innervation and reinnervation. Arch Otolaryngol. 1974;99:34-44.PubMedGoogle Scholar
  32. 32.
    Kimata Y, Uchiyama K, Ebihara S, et al. Comparison of innervated and noninnervated free flaps in oral reconstruction. Plast Reconstr Surg. 1999;104:1307-1313.PubMedCrossRefGoogle Scholar
  33. 33.
    Lahteenmaki T, Waris T, Asko-Seljavaara S, et al. Recovery of sensation in free flaps. Scand J Plast Reconstr Surg Hand Surg. 1989;23:217-222.PubMedCrossRefGoogle Scholar
  34. 34.
    Carroll D. A quantitative test of upper extremity function. J Chron Dis. 1965;18:479-491.PubMedCrossRefGoogle Scholar
  35. 35.
    Petruzzo P, Lanzetta M, Dubernard JM, et al. The international registry on hand and composite tissue transplantation. Transplantation. 2008;86:487-492.PubMedCrossRefGoogle Scholar

Copyright information

© Springer London 2011

Authors and Affiliations

  • Maria Z. Siemionow
    • 1
    Email author
  • Can Ozturk
  • Selman Altuntas
  1. 1.Department of Plastic SurgeryCleveland ClinicClevelandUSA

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