Immunosuppression in Composite Tissue Allotransplantation



Composite tissue allotransplantation (CTA) is emerging as a new modality in reconstructive surgery as potential treatment for complex tissue, anatomic and functional defects. While the technical aspects of such procedures are constantly undergoing refinement, the practical issues due to the need and as a result, lifelong risks of exposure to the immunosuppressive drugs, remains as a major drawback. The implementation of induction and maintenance therapy protocols used in solid organ transplantation (SOT) has resulted in excellent patient and graft survival in CTA and has minimized the risk of graft loss due to uncontrolled rejection. Further understanding of the mechanisms and tempo of graft acceptance and rejection in CTA may lead to protocols that minimize the need for maintenance immunosuppressive therapy and as a result reduce the risk for long-term side effects.


Acute Rejection Immunosuppressive Agent Solid Organ Transplantation Mycophenolic Acid Mixed Chimerism 





Antithymocyte globulin


Calcineurin inhibitors


Composite tissue allotransplantation




Hematopoietic stem cell




Mycophenolate mofetil


Mycophenolic acid




Solid organ transplantation




Therapeutic drug monitoring


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Copyright information

© Springer London 2011

Authors and Affiliations

  1. 1.Department of HPB/Liver Transplant SurgeryCleveland ClinicClevelandUSA

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