Experimental Studies in Face Transplantation: Rodent Model

  • Maria Z. Siemionow
  • Fatih Zor


Rodents, especially rats, are the most frequently used animals in composite tissue allotransplantation (CTA) studies. There are several advantages of using rodents in experimental studies especially in transplantation studies. During the past 20 years of our research in the field of CTA transplants, we have designed and developed different craniofacial CTA models in rats testing different immunosuppressive protocols of tolerance induction. These models include full face/scalp transplants, hemiface transplants, composite hemiface/calvarium transplants, rat maxilla allotransplants, composite osteomusculocutaneous hemiface/mandible/tongue-flap transplants, and composite midface allotransplants. These models and the models that will be developed in the future will provide the scientific foundation for future success in CTA transplantation in the clinical setting.


Facial Nerve Common Carotid Artery External Jugular Vein Superficial Temporal Artery Zygomatic Arch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



cyclosporine A


composite tissue allotransplantation


motor evoked potentials


major histocompatibility complex


somatosensory evoked potentials


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Copyright information

© Springer London 2011

Authors and Affiliations

  1. 1.Department of Plastic SurgeryCleveland ClinicClevelandUSA

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