International Registry of Face Transplantation

  • Palmina Petruzzo
  • Marco Lanzetta
  • Jean Michel Dubernard


The International Registry on Hand and Composite Tissue Transplantation (IRHCTT) was founded in 2002 and its purpose was to collect detailed information from every case of hand and face transplantation providing a unique opportunity for the teams to share their experiences and to keep abreast of the latest developments. The registry of face transplantation presents some peculiar characteristics as face is considered a complex “organ” constituted of anatomic parts with different functions. In the Registry facial deficits are expressed as “aesthetic units,” adding also the depth of the defect; and in the procedure section, it is not only important to report the transplanted aesthetic units but also to detail all the grafted tissues, vascular anastomoses, nerve repairs, and eventual additional surgical procedures. Immunosuppressive regimen, rejection episodes, side effects, or other complications are fully reported. The evaluation of outcomes is difficult as disfigurement involves different parts of face with loss of various functions. Consequently, it is important to evaluate both aesthetic and functional results, detailing the recovered functions, such as swallowing, eating and drinking, speaking, or opening and closing eyelids. Two items, such as “Psychological and social acceptance” and “Patient satisfaction and general well-being” are also reported as the goal of face transplantation is to allow the patient to have a social life and improved quality of life.


Rejection Episode Nerve Repair Dash Score Anatomic Part Motion Recovery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Composite tissue allotransplantation


functional magnetic resonance imaging


International Registry on Hand and Composite Tissue Transplantation


Semmes-Weinstein Monofilament Test


Weinstein Enhanced Sensory


  1. 1.
    Lanzetta M, Petruzzo P, Margreiter R, Dubernard JM, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation. 2005;15(79):1210-1214.CrossRefGoogle Scholar
  2. 2.
    Lanzetta M, Petruzzo P, Dubernard JM, et al. Second report (1998–2006) of the International Registry of Hand and Composite Tissue Transplantation. Transpl Immunol. 2007;18:1-6.PubMedCrossRefGoogle Scholar
  3. 3.
    Petruzzo P, Lanzetta M, Dubernard JM, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation. 2008;86:487-492.PubMedCrossRefGoogle Scholar
  4. 4.
    Sieminonow M, Sonmez E. Face as an organ. Ann Plast Surg. 2008;61(3):345-352.CrossRefGoogle Scholar
  5. 5.
    Gordon CR, Siemionow M, Coffman K, et al. The Cleveland clinic FACES score: a preliminary assessment tool for identifying the optimal face transplant candidate. J Craniofac Surg. 2009;20:1969-1974.PubMedCrossRefGoogle Scholar
  6. 6.
    Dubernard JM, Lengele B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med. 2007;357:2451-2460.PubMedCrossRefGoogle Scholar
  7. 7.
    Hivelin M, Siemionow M, Grimbert P, Lantieri L. Extracorporeal photopheresis: from solid organs to face transplantation. Transpl Immunol. 2009;21:117-128.PubMedCrossRefGoogle Scholar
  8. 8.
    Cendales LC, Kanitakis J, Schneeberger S, et al. The Banff 2007 working classification of skin-containing composite tissue allograft pathology. Am J Transplant. 2008;8:1396-1400.PubMedCrossRefGoogle Scholar
  9. 9.
    Giraux P, Sirigu A, Schneider F, Dubernard JM. Cortical reorganization in motor cortex after graft of both hands. Nat Neurosci. 2001;4:1.CrossRefGoogle Scholar
  10. 10.
    Gummesson C, Atroshi I, Ekdahl C. The disabilities of the arm, shoulder and hand (DASH) outcome questionnaire: longitudinal construct validity and measuring self-rated health change after surgery. BMC Musculoskelet Disord. 2003;16:11.CrossRefGoogle Scholar
  11. 11.
    Rosenberg M. Society and the Adolescent Self-image. Princeton, NJ: Princeton University Press; 1965.Google Scholar

Copyright information

© Springer London 2011

Authors and Affiliations

  • Palmina Petruzzo
    • 1
  • Marco Lanzetta
  • Jean Michel Dubernard
  1. 1.Department of TransplantationEdouard Herriot HospitalLyonFrance

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