Clinical Facial Composite Tissue Allotransplantation: A Review of the Global Experience and Future Implications
Since 2005, 11 facial composite tissue allotransplantations (CTA) have been performed in 8 different centers in 6 countries. Five teams have reported their work and outcomes in separate publications. We review in detail the first four global experiences and compare indications, donor/recipient matching criteria, CTA graft anatomy, immunosuppressive protocols, and postoperative course. A thorough review of the eight publications by five transplantation groups was conducted. Additional information gathered from official press releases were also included for review. Some details of the remaining transplants are also discussed to facilitate evaluation of indications, matching criteria and future directions for facial CTA.
KeywordsHuman Leukocyte Antigen Acute Rejection Mycophenolate Mofetil Chronic Rejection Skin Tone
Composite Tissue Allotransplantation
Graft vs. Host disease
Nerve Conduction Studies
Pressure-Specified Sensory Device
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