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Immunological Aspects of Face Transplantation

  • Aleksandra Klimczak
  • Maria Z. Siemionow
Chapter

Abstract

Human facial transplantation is a form of composite tissue allotransplantation (CTA), and since November 2005, it has become a clinical reality. Face transplantation is still considered an experimental procedure in the clinic, and to date, 13 facial transplantations have been performed worldwide. We observe the progress in composite facial tissue allotransplantation, partial or full facial transplantation for severely disfigured patients. Facial CTA involves the transplantation of different type of tissues carrying different functions and immunologic characteristics. Immunogenicity of tissue components of the facial allograft and immunosuppressive strategies that reduce allogenic responses against the graft are discussed in this chapter.

Keywords

Major Histocompatibility Complex Class Calcineurin Inhibitor Kidney Transplant Recipient Transplantation Tolerance Vessel Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

APC

antigen-presenting cell

ATG

anti-thymocyte immunoglobulin

CsA

cyclosporine A

CTA

composite tissue allotransplantation

CTLA

cytotoxic T lymphocyte–associated antigen

DDC

dermal dendritic cell

GVHD

graft vs. host disease

ICAM

intercellular adhesion molecule

IRHCTT

The International Registry on Hand and Composite Tissue Transplantation

LC

Langerhans cell

LFA

leukocyte function–associated antigen

mAb

monoclonal antibody

MHC

major histocompatibility complex

MMF

mycophenolate mofetil

NHP

non-human primates

PTLD

post-transplant lymphoproliferative disorder

RAPA

rapamycin

SALT

skin-associated lymphoid tissue

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Copyright information

© Springer London 2011

Authors and Affiliations

  1. 1.Department of Plastic SurgeryCleveland ClinicClevelandUSA

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