Abstract
The brain is constantly adapting to new inputs from the environment. New noninvasive techniques are available to scrupulously study cortical plasticity. Several studies have proven that changes in neural pathways occur due to denervation from injury such as amputation. Changes that occur rapidly are likely due to unmasking of established synapses that are latent, while changes that occur over long periods of time are more likely due to establishment of new neural connections. Cortical reorganization that occurs from traumatic amputation has been shown to be reversible with replantation and transplantation. With the new field of composite tissue transplantation, such as hand or face, it is critical to be aware of these changes in order to choose potential patients and to modify their rehabilitation based on our understanding of the cortical reorganization that occurs over time.
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Abbreviations
- BOLD:
-
Blood oxygenation level dependent
- fMRI:
-
Functional Magnetic Resonance Imaging
- GABA:
-
Gamma-aminobutyric acid
- Hb:
-
Hemoglobin
- HbO2 :
-
Oxygenated hemoglobin
- ICF:
-
Intracortical facilitation
- MEP:
-
Motor-evoked potentials
- MT:
-
Motor threshold
- NMDA:
-
N-methyl-d-aspartate
- PMC:
-
Premotor cortex supplementary motor area (SMA)
- SMA:
-
Supplementary motor area
- SICI:
-
Short interval intracortical inhibition
- TMS:
-
Transcranial magnetic stimulation
References
Ramachandran VS, Stewart M, Rogers-Ramachandran DC. Perceptual correlates of massive cortical reorganization. NeuroReport. 1992;3:583-586.
Seong-Gi Kim, Bandettini Peter. Principles of functional MRI. In: Faro Scott, Mohammed Feroze, eds. Functional MRI: Basic Principles and Clinical Applications. New York: Springer; 2006:3-23.
Stippich Christopher. Introduction to presurgical functional MRI. In: Baert AL, Knauth M, Sator K, eds. Medical Radiology Diagnostic Imaging: Clinical Functional MRI. Berlin: Springer; 2007:1-7.
Ogawa S, Lee TM, Kay AS, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA. 1990;87:9868-9872.
Cohen MS, Bookheimer SY. Localization of brain function using magnetic resonance imaging. Trends Neurosci. 1994;17:268-277.
Barker Anthony T. The history and basic principles of magnetic nerve stimulation. In: Pascual-Leone A, Davey NJ, Rothwell J, Wasserman EM, Puri BK, eds. Handbook of Transcranial Magnetic Stimulation. New York: Arnold; 2002:3-17.
Wassermann EM, McShane LM, Hallet M, Cohen LG. Noninvasive mapping of muscle representations in human motor cortex. Electroencephalogr Clin Neurophysiol. 1992;85:1-8.
Cohen LG, Mano Y. Neuroplasticity and transcranial magnetic stimulation. In: Pascual-Leone A, Davey NJ, Rothwell J, Wasserman EM, Puri BK, eds. Handbook of Transcranial Magnetic Stimulation. New York: Arnold; 2002:346-357.
Borsook D, Becerra L, Fishman S, et al. Acute plasticity in human somatosensory cortex following amputation. NeuroReport. 1998;9:1013-1017.
Cruz VT, Nunes B, Reis AM, Pereira JR. Cortical remapping in amputees and dyslemic patients: a functional MRI study. NeuroRehabilitation. 2003;18:299-305.
Cohen LG, Bandinelli S, Findley TW, Hallet M. Motor reorganization after upper limb amputation in man. Brain. 1991;114:615-627. Pt 1B.
Schwenkreis P, Witscher K, Janssen F, et al. Changes of cortical excitability in patients with upper limb amputation. Neurosci Lett. 2000;293:143-146.
Jacobs KM, Donoghue JP. Reshaping the cortical motor map by unmasking latent intracortical connections. Science. 1991;251:944-947.
Garraghty PE, Muja N. NMDA receptors and plasticity in adult primate somatosensory cortex. J Comp Neurol. 1996;367:319-336.
Bjorkman A, Waites A, Rosen B, Lundborg G, Larsson EM. Cortical sensory and motor response in a patient whose hand has been replanted: one-year follow up with functional magnetic resonance imaging. Scand J Plast Reconstr Surg Hand Surg. 2007;41:70-76.
Roricht S, Machetanz J, Niehaus L, Biemer E, Meyer BU. Reorganization of human motor cortex after hand replantation. Ann Neurol. 2001;50:240-249.
Piza-Katzer H, Brenneis C, Loscher WN, et al. Cortical motor activation patterns after hand transplant and replantation. Acta Neurochir Suppl. 2007;100:113-115.
Giraux P, Sirigu A, Schneider F, Dubernard JM. Cortical reorganization in motor cortex after graft of both hands. Nat Neurosci. 2001;4:691-692.
Sanes JN, Suner S, Donoghue JP. Dynamic organization of primary motor cortex output to target muscles in adult rats. I. Long term patterns of reorganization following motor or mixed peripheral nerve lesions. Exp Brain Res. 1990;79:479-491.
Donoghue JP, Suner S, Sanes JN. Dynamic organization of primary motor cortex output to target muscles in adult rats. II. Rapid reorganization following motor nerve lesions. Exp Brain Res. 1990;79:492-503.
Pons TP, Garraghty PE, Ommaya AK, Kaas JH, Taub E, Mishkin M. Massive cortical reorganization after sensory deafferentation in adult macaques. Science. 1991;252:1857-1860.
Yang TT, Gallen CC, Ramachandran VS, Cobb S, Schwartz BJ, Bloom FE. Noninvasive detection of cerebral plasticity in adult human somatosensory cortex. NeuroReport. 1994;5:701-704.
Rijntjes M, Tegenthoff M, Liepert J, et al. Cortical reorganization in patients with facial palsy. Ann Neurol. 1997;41:621-630.
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Mendiola, A., Siemionow, M.Z. (2011). Methods of Assessment of Cortical Plasticity in Patients Following Amputation, Replantation, and Composite Tissue Allograft Transplantation. In: Siemionow, M. (eds) The Know-How of Face Transplantation. Springer, London. https://doi.org/10.1007/978-0-85729-253-7_22
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DOI: https://doi.org/10.1007/978-0-85729-253-7_22
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