Recent advances in immunosuppression and surgical techniques have progressed to make face transplants possible. These composite tissue grafts consist of skin, subcutaneous tissue, muscle, nerve, and bone. Accurate clinical and histologic rejection surveillance is vital to preserve the function of the graft. In December 2008, the first near-total face transplant was performed. Reviewing the pathology from this case reveals that the clinical impression and skin histology showed good correlation. However, the mucosal biopsies showed histologic signs of acute cellular rejection that far exceeded that of the skin biopsies. This discrepancy made it difficult for the pathology team to decide with certainty whether these changes truly represented acute cellular rejection.
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Acute cellular rejection
Cleveland Clinic Foundation
Hematoxylin & Eosin
Periodic Acid-Schiff Stain
Terminal deoxynucleotidyl transferase dUTP nick end labeling
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