Advertisement

Introduction

  • Pankaj Sharma
  • James F. Meschia
Chapter

Abstract

This chapter briefly describes the background evidence of why stroke has an inherited component and places it in context with other common disorders. It goes on to suggest ways of managing inherited stroke conditions in the general clinic.

Keywords

Ischemic Stroke Stroke Patient Mendelian Randomization Stroke Clinic Stroke Physician 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442. doi:  10.1371/journal.pmed.0030442.PubMedCrossRefGoogle Scholar
  2. 2.
    Ezzati M, Van der Hoorn S, Rodgers A, Lopez AD, Mathers CD, Murray CJL, Comparative Risk Assessment Collaborating Group. Estimates of global and regional potential health gains from reducing multiple major risk factors. Lancet. 2003;362:271–80.PubMedCrossRefGoogle Scholar
  3. 3.
    Floßmann E, Schulz UGR, Rothwell PM. Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke. 2004;35:212–27.PubMedCrossRefGoogle Scholar
  4. 4.
    Woo D, Sauerbeck LR, Kissela BM, Khoury JC, Szaflarski JP, Gebel J, et al. Genetic and environmental risk factors for intracerebral haemorrhage. Preliminary results of a population-based study. Stroke. 2002;33:1190–6.PubMedCrossRefGoogle Scholar
  5. 5.
    van Gijn J, Rinkel JE. Subarachnoid haemorrhage: diagnosis, causes and management. Brain. 2001;124:249–78.PubMedCrossRefGoogle Scholar
  6. 6.
    Kissela BM, Sauerbeck L, Woo D, Khoury J, Carrozzella J, Pancioli A, et al. Subarachnoid haemorrhage. A preventable disease with a heritable component. Stroke. 2002;33:1321–6.PubMedCrossRefGoogle Scholar
  7. 7.
    Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005;111(25):3481–8.PubMedCrossRefGoogle Scholar
  8. 8.
    The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447(7145):661–78.CrossRefGoogle Scholar
  9. 9.
    Hyttinen V, Kaprio J, Kinnunen L, Koskenvuo M, Tuomilehto J. Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes. 2003;52:1052–5.PubMedCrossRefGoogle Scholar
  10. 10.
    Kobberling J, Tattersall R, editors. The genetics of diabetes mellitus. London: Academic Press; 1982.Google Scholar
  11. 11.
    Touze E, Rothwell PM. Heritability of ischaemic stroke in women compared with men: a genetic epidemiological study. Lancet Neurol. 2007;6:125–33.PubMedCrossRefGoogle Scholar
  12. 12.
    Touze E, Rothwell PM. Sex-differences in heritability of ischemic stroke: a systematic review and meta-analysis. Stroke. 2008;39(1):16–23.PubMedCrossRefGoogle Scholar
  13. 13.
    Chinnery PF, Elliott HR, Syed A, Rothwell PM, Oxford Vascular Study. Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study. Lancet Neurol. 2010;9(5):498–503.PubMedCrossRefGoogle Scholar
  14. 14.
    Nitsch D. Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. Am J Epidemiol. 2006;163(5):397–403.PubMedCrossRefGoogle Scholar
  15. 15.
    Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: evidence on a causal link from Mendelian randomisation. Lancet. 2005;365(9455):224–32.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Imperial College Cerebrovascular Research Unit (ICCRU)Imperial College London and Hammersmith HospitalsLondonUK
  2. 2.Department of Neurology, Cerebrovascular DivisionMayo Clinic FloridaJacksonvilleUSA

Personalised recommendations