Advertisement

Overview of Thermal Ablation Devices: Radiofrequency Ablation

  • Miltiadis Krokidis
  • Irfan Ahmed
Chapter
Part of the Techniques in Interventional Radiology book series (TECHRAD)

Abstract

“Thermal ablation” is de fi ned as the application of heating agents to a specific area of the body with the intention of tissue destruction. The deleterious effect of heat is based on the fact that when biological tissues reach a temperature above 45°C, irreversible cell damage occurs. Radiofrequency (RF) ablation is based on the interaction between high-f requency, rapidly alternating electric current and biological tissue. The rapidly alternating electric current causes vibration movement of the tissue’s bipolar molecules (mostly water). This vibration movement is transmitted between adjacent molecules with resulting frictional energy loss. The energy loss is deposited in the biological tissues in the form of a rise in temperature. The rise in temperature leads initially to hyperthermia and then to “coagulation” necrosis.

Keywords

Ablation Zone Tissue Impedance Christmas Tree Vibration Movement Tract Ablation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Reading

  1. Ahmed M, Lukyanov AN, Torchilin V, et al. Combined radiofrequency ablation and adjuvant liposomal chemo- therapy: effect of chemotherapeutic agent, nanoparticle size, and circulation time. J Vasc Interv Radiol. 2005a;16(10):1365–71.PubMedCrossRefGoogle Scholar
  2. Ahmed M, Liu Z, Lukyanov AN, et al. Combination radiofrequency ablation with intratumoral liposomal doxorubicin: effect on drug accumulation and coagulation in multiple tissues and tumor types in animals. Radiology. 2005b;235(2):469–77.PubMedCrossRefGoogle Scholar
  3. Brown DB, Gould JE, Gervais DA, et al. Transcatheter therapy for hepatic malignancy: standardization of terminology and reporting criteria. J Vasc Interv Radiol. 2007;18(12):1469–78. Review.PubMedCrossRefGoogle Scholar
  4. Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Roentgenol. 2000;174(2):323–31.PubMedGoogle Scholar
  5. LeVeen RF. Laser hyperthermia and radiofrequency ablation of hepatic lesions. Semin Interv Radiol. 1997;14:313–24.Google Scholar
  6. Meijerink MR, van der Tol P, van Tilborg AA. Radiofrequency ablation of large size liver tumors using novel plan-parallel expandable bipolar electrodes: initial clinical experience. Eur J Radiol. 2011;77(1):167–71. Epub ahead of print July 17, 2009.PubMedCrossRefGoogle Scholar
  7. Organ LW. Electrophysiologic principles of radiofrequency lesion making. Appl Neurophysiol. 1976–1977;39:69–76.Google Scholar
  8. Pereira PL, Trubenbach J, Schenk M, et al. Radiofrequency ablation: in vivo comparison of four commercially available devices in pig livers. Radiology. 2004;232(2):482–90.PubMedCrossRefGoogle Scholar
  9. Poon RT, Ng KK, Lam CM, et al. Learning curve for radiofrequency ablation of liver tumours: prospective analysis of initial 100 patients in a tertiary institution. Ann Surg. 2004;239(4):441–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of RadiologyGuy’s and St Thomas’ NHS Trust, St Thomas’ HospitalLondonUK

Personalised recommendations