Likelihood of Life’s Protein Machines: Extravagant in Construction Yet Efficient in Function
A protein with its specified sequence, where each position is filled by but 1 of 20 different amino acid residues, represents an extremely improbable construct. Perhaps in part because of this improbability, searches for understanding have reasonably considered far-from-equilibrium conditions and addressed circumstances whereby order may appear out of chaos. On the other hand, biochemists with painstaking commitment have worked their way down to the component processes of DNA replication, of transcription of DNA into RNA, and of translation of RNA into protein sequence. They dissected each constituent process into its scores of energy-requiring reactions, assembled these reactions to provide a compelling description of each component, and emerged with a stunning tale of heredity and protein biosynthesis. Biology’s story of protein biosynthesis is one of such elegant detail that, no matter how brilliant the mind, it could not have been derived otherwise.
KeywordsAmino Acid Residue Peptide Bond Protein Biosynthesis Residue Protein tRNA Molecule
Unable to display preview. Download preview PDF.
- 1.See for example D. Voet and J. Voet, Biochemistry. Second Edition, John Wiley & Sons, Inc., New York, 1995, Chapter V. The Expression and Transmission of Genetic Information, pp 830–1019.Google Scholar
- 2.See for example D. Voet and J. Voet, Biochemistry. Second Edition, John Wiley & Sons, Inc., New York, 1995; standard free energies of phosphate hydrolysis, Table 15-3, page 430.Google Scholar
- 3.K. Kinosita, Jr., R. Yasuda, and H. Noji, “F1-ATPase: a highly efficient rotary ATP machine.” In “Essays in Biochemistry: Molecular Motors” 35, 3–18, 2000, Edited by G. Banting and S.J. Higgins, Portland Press Ltd 59 Portland Place, London, W1N 3AJ, U.K.Google Scholar