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Selective Regulation of Protein Activity by Complex Ca2+ Oscillations: A Theoretical Study

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Mathematical Modeling of Biological Systems, Volume I

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Summary

Calcium oscillations play an important role in intracellular signal transduction. As a second messenger, Ca2+ represents a link between several input signals and several target processes in the cell. Whereas the frequency of simple Ca2+ oscillations enables a selective activation of a specific protein and herewith a particular process, the question arises of how at the same time two or more classes of proteins can be specifically regulated. The question is general and concerns the problem of how one second messenger can transmit more than one signal simultaneously (bow-tie structure of signalling). To investigate whether a complex Ca2+ signal like bursting, a succession of low-peak and high-peak oscillatory phases, could selectively activate different proteins, several bursting patterns with simplified square pulses were applied in a theoretical model. The results indicate that bursting Ca2+ oscillations allow a differential regulation of two different calcium-binding proteins, and hence, perform the desired function.

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Authors and Affiliations

  1. Dept. of Bioinformatics, Faculty of Biology and Pharmaceutics, Friedrich-Schiller University of Jena, Ernst-Abbe-Platz 2, D-07743 Jena, Germany

    Marko Marhl

  2. Dept. of Physics, Faculty of Education, University of Maribor, Maribor, University of Maribor, 2000 Maribor, Slovenia, Koroška cesta 160

    Beate Knoke & Stefan Schuster

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  1. Beate Knoke
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  2. Marko Marhl
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  3. Stefan Schuster
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Editors and Affiliations

  1. Center for Information Services and High Performance Computing, Technische Universität Dresden, 01062 Dresden, Germany

    Andreas Deutsch

  2. Center for Information Services and High Performance Computing, Technische Universität Dresden, 01062 Dresden, Germany

    Lutz Brusch

  3. Centre for Mathematical Medicine School of Mathematical Sciences, University of Nottingham, Nottingham, NG7 2RD, U.K

    Helen Byrne

  4. Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB T6G 2G1, Canada

    Gerda de Vries

  5. Institute of Theoretical Biology, Humboldt-Universität zu Berlin Invalidenstraße 43, 10115 Berlin, Germany

    Hanspeter Herzel

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Knoke, B., Marhl, M., Schuster, S. (2007). Selective Regulation of Protein Activity by Complex Ca2+ Oscillations: A Theoretical Study. In: Deutsch, A., Brusch, L., Byrne, H., Vries, G.d., Herzel, H. (eds) Mathematical Modeling of Biological Systems, Volume I. Modeling and Simulation in Science, Engineering and Technology. Birkhäuser Boston. https://doi.org/10.1007/978-0-8176-4558-8_2

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