Biochemical and Biomechanical Aspects of Blood Flow

  • M. Thiriet
Part of the Modeling and Simulation in Science, Engineering and Technology book series (MSSET)


The blood vital functions are adaptative and strongly regulated. The various processes associated with the flowing blood involve multiple space and time scales. Biochemical and biomechanical aspects of the human blood circulation are indeed strongly coupled. The functioning of the heart, the transduction of mechanical stresses applied by the flowing blood on the endothelial and smooth muscle cells of the vessel wall, gives examples of the links between biochemistry and biomechanics in the physiology of the cardiovascular system and its regulation. The remodeling of the vessel of any site of the vasculature (blood vessels, heart) when the blood pressure increases, the angiogenesis, which occurs in tumors or which shunts a stenosed artery, illustrates pathophysiological processes. Moreover, focal wall pathologies, with the dysfunction of its biochemical machinery, such as lumen dilations (aneurisms) or narrowings (stenoses), are stress-dependent. This review is aimed at emphasizing the multidisciplinary aspects of investigations of multiple aspects of the blood flow


Nitric Oxide Wall Shear Stress Focal Adhesion Kinase Biological Material Atrial Natriuretic Peptide 


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Copyright information

© Birkhäuser Boston 2007

Authors and Affiliations

  • M. Thiriet
    • 1
    • 2
  1. 1.REO team Laboratoire Jacques-Louis Lions, UMR CNRS 7598Université Pierre et Marie CurieParis cedex 05
  2. 2.INRIALe Chesnay Cedex

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