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The Significance and Function of Preputial Langerhans Cells

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Male and Female Circumcision

Abstract

In 1996, my attention was drawn to an article published in Science called “Circumcision May Protect Against the Aids Virus.” Jean Marx, the editor, claimed:

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References

  1. Marx JL. Circumcision may protect against the AIDS virus. Science 1989;248:470–1.

    Article  Google Scholar 

  2. Langerhans P. Contributions to the Microscopic Anatomy of the Pancreas. Berlin. 1869. H Morrison H, trans. Baltimore: John Hopkins Press 1932:1–7.

    Google Scholar 

  3. Langerhans P. Über die Nerven der menschlichen Haut. Virchow Arch (Path Anat) 1868;44:325–37.

    Article  Google Scholar 

  4. Lampert F. Langerhans cell histiocytosis-historical perspectives Hemato1 Oncol Clin North Am 1998;12:213–4.

    Article  CAS  Google Scholar 

  5. Stingl G. Chairman for the organisation of the Fifth International Workshop on Langerhans Cells which was held in Salzburg, Austria on the 5-7th September 1997. The Abstracts were published in: J Invest Dermatol 1997;109:253–68. Website references for this workshop are listed at http://www.pslgroup.coddg/ed76.htm, http://cmmg.biosci.wayne.edu/asg/langerhans.html.

    Article  Google Scholar 

  6. Nezelof C, Basset F. Langerhans cell histiocytosis research. Hematol Oncol Clin North Am 1998;12:385–406.

    Article  PubMed  CAS  Google Scholar 

  7. Streilein JW, Bergstresser PR. Langerhans cells: antigen presenting cells of the epidennis. Immunobiology 1984;168:285–300.

    PubMed  CAS  Google Scholar 

  8. Stingl G, Aberer W. In: Goldsmith LA, ed. The Langerhans’ cell. New York: Oxford University Press. 1983:907–20.

    Google Scholar 

  9. Foster CA, Holbrook KA. Ontogenic expression of HLA-DR and OKT-6 determinants by human embryonic and fetal Langerhans cells. Clin Res 1983;33:637A.

    Google Scholar 

  10. Halliday GM, Cavanagh L, Barnetson RSC. Regulation of the skin immune system by local antigen presenting cells Today’s Life Science. 1990;2(11):26–34.

    Google Scholar 

  11. Dezutter-Dambuyant C. [Recent data and current studies of epidermal Langerhans cells]. Pathol Biol Paris 1995;43:841–7.

    PubMed  CAS  Google Scholar 

  12. Tang AM, Amagai M, Granger LG, Stanley JR, Udey MC. Adhesion of epidermal Langerhans cells to keratinocytes mediated by e-cadherin. Nature 1993;361:82–5.

    Article  PubMed  CAS  Google Scholar 

  13. Udey MC. Cadherins and Langerhans cell immunobiology. Clin Exp Immunol (Suppl) 1997;107:6–8.

    PubMed  CAS  Google Scholar 

  14. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Name 1993;363:159–63.

    CAS  Google Scholar 

  15. Kanitakis J, Hoyo E, Perrin C, Schmitt D. Electron-microscopic observation of a human epidermal Langerhans cell in mitosis. J Dermatol 1993;20:35–9.

    PubMed  CAS  Google Scholar 

  16. Stingl G, Bergstresser PR. Dendritic cells: a major story unfolds Immunol Today 1995;16:30–3.

    Article  Google Scholar 

  17. Rowden G. The Langerhans cell. Crit Rev Immunol 1981;3:95–180.

    PubMed  CAS  Google Scholar 

  18. Birbeck MSC, Braethnach AS, Everall J. An electron microscopic study of basal melanocyte and high level clear cell (Langerhans cell) in vitiligo. J Invest Dermatol 1961;37:51–63.

    Article  Google Scholar 

  19. Bucana CD, Munn CG, Song MJ, Dunner K, Kripke ML. Internalisation of Ia-molecules into birbeck granule-like structures in murine dendritic cells. J Invest Dermatol 1992;99:365–73.

    Article  PubMed  CAS  Google Scholar 

  20. Demarchez M, Asselineau D, Czernielewski J. Migration of Langerhans cells into human epidermis of “reconstructed” skin, normal skin, or healing skin, after grafting onto the nude mouse. J Invesf Dermatol 1993;100:648–52.

    Article  CAS  Google Scholar 

  21. Enk AH, Angeloni VL, Udey MC, Katz SI. An essential role for Langerhans cell-derived IL-1β in the initiation of primary immune responses in skin. J Immunol 1993;150:3698–3704.

    PubMed  CAS  Google Scholar 

  22. Hogan AD, Burks AW. Epidermal Langerhans cells and their function in the skin immune system. Ann Allergy Asthma Immunol 1995;75:5–10.

    PubMed  CAS  Google Scholar 

  23. Chu T, Jaffe R. The normal Langerhans cell and the LCH cell. Br J Cuncer (Supplement) 1994;23:S4–10.

    CAS  Google Scholar 

  24. Hussain LA, Lehner T. Comparative Investigation of Langerhans cells and potential receptors for HIV in oral, genito-urinary, and rectal epithelia. Immunology 1995;85:475–84.

    PubMed  CAS  Google Scholar 

  25. Van Wdsem EJ, Breve J, Kleijmeer M, Kraal G. Antigen-bearing Langerhans cells in skin draining lymph nodes: phenotype and kinetics of migration. J Invest Dennutol 1994;103:217–20.

    Article  Google Scholar 

  26. Ishii E, Watanabe S. Biochemistry and biology of the Langerhans cell. Hematol Oncol Clin North Am 1987;1:99–118.

    PubMed  CAS  Google Scholar 

  27. Stingl G, Wolff-Schreiner EC, Pichler WJ, Gschnait F, Knapp W, Wolff K. Epidermal Langerhans cells bear Fc and C3 receptors Nature 1977;268:245–6.

    Article  PubMed  CAS  Google Scholar 

  28. Kannourakis G, Abbas A. The role of cytokines in the pathogenesis of Langerhans’ cell histiocytosis. Br J Cancer 1994;70:S37.

    CAS  Google Scholar 

  29. Weiss GN, Sanders M, Westbrook KC. The Distribution and Density of Langerhans Cells in the Human Prepuce: Site of a Diminished Immune Response? Israel J Med Sci 1993;29:42–3. http://www.users.dircon.co.uk/~vernon/G_Weiss/langerhans.html

    PubMed  CAS  Google Scholar 

  30. Weiss GN. Post Presentation Comments on: The Distribution and Density of Langerhans Cells in the Human Prepuce: Site of a Diminished Immune Response? Israel J Med Sci 1993;29:42–3. (February 1997). http://www.usersdircon.co.uk/-vernon/G-Weissflangerhans.htd

  31. Hussain LA, Lehner T. Comparative investigation of Langerhans’ cells and potential receptors for HIV in oral, genitourinary, and rectal epithelia. Immunology 1995;85:475–84.

    PubMed  CAS  Google Scholar 

  32. Ritter RJ, Denniston GC. Say No to Circumcision. 2ndEdition. Aptos: Hourglass Book Publishing. 1996:18–1.

    Google Scholar 

  33. Bos JD. The skin as an organ of immunity. Clin Enp Immunol (Supplement 1) 1997;107:3–5.

    Google Scholar 

  34. Bressler RS, Bressler CH. Functional anatomy of the skin. Clin Podiatr Med Surg 1989;6:229–46.

    PubMed  CAS  Google Scholar 

  35. Shinmada S, Katz SI. The skin as an immunologic organ. Arch Path Lab Med 1988;112:231–4.

    Google Scholar 

  36. Salmon JK, Armstrong CA, Ansel JC. The skin as an immune organ. West J Med 1994;160:146–152.

    PubMed  CAS  Google Scholar 

  37. Simon JC. [The skin—an immunocompetent organ]. Fortschr Med 1994;112:293–5.

    PubMed  CAS  Google Scholar 

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Authors
  1. George L. Williams
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Editor information

Editors and Affiliations

  1. University of Washington, Seanle, Washington

    George C. Denniston

  2. Wellcome Unit for the History of Medicine, University of Oxford, Oxford, England

    Frederick Mansfield Hodges

  3. National Organization of Circumcision Information Resource Centers, San Anselmo, California

    Marilyn Fayre Milos

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© 1999 Kluwer Academic / Plenum Publishers, New York

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Williams, G.L. (1999). The Significance and Function of Preputial Langerhans Cells. In: Denniston, G.C., Hodges, F.M., Milos, M.F. (eds) Male and Female Circumcision. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-39937-9_4

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  • DOI: https://doi.org/10.1007/978-0-585-39937-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46131-6

  • Online ISBN: 978-0-585-39937-9

  • eBook Packages: Springer Book Archive

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