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Reperfusion 12 Hours after Coronary Occlusion Salvages Myocardium in Dogs: Studies in a Single-Heart Model

  • Akio Kimura
  • Kinji Ishikawa
  • Iwao Ogawa
  • Hironari Koka
  • Shoji Nakai
  • Masahiko Inagaki
  • Masaru Miyataka
  • Takaya Hasegawa
  • Ryo Katori
Part of the Progress in Experimental Cardiology book series (PREC, volume 1)

Abstract

In our single-heart model, half permanently occluded and half reperfused, reperfusion 12 hours after coronary artery occlusion salvaged myocardium in dogs. This finding may be one of the reasons why late reperfusion is beneficial in patients with acute myocardial infaction.

Keywords

Acute Myocardial Infarction Left Anterior Descend Coronary Occlusion Myocardial Salvage Regional Myocardial Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Katori R, Ishikawa K, Kanamasa K, Morishita M, Ohno M, Ogawa I, Namikawa H, Okayama A. 1987. Improved prognosis after coronary thrombolysis with urokinase in acute myocardial infarction. Jpn Heart J 28:863–872.PubMedGoogle Scholar
  2. 2.
    Kennedy JW, Martin GV, Davis KB, Maynard C, Stadius M, Sheehan FH, Ritchie JL. 1988. The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction randomized trial. Circulation 77:345–352.PubMedGoogle Scholar
  3. 3.
    Gunnar RG, Bourdillon PDV, Dixon DW, Fuster V, Karp RB, Kennedy JW, Klocke FJ, Passamani ER, Pitt B, Rapaport E, Reeves TJ, Russell RO Jr, Sobel BE, Winters WL Jr. 1990. ACC/AHA guidelines for the early management of patients with acute myocardial infarction. Circulation 82:664–707.PubMedGoogle Scholar
  4. 4.
    Serruys PW, Simoons ML, Suryapranata H, Vermeer F, Wijns W, Brand M, BÄR F, Zwaan C, Krauss XH, Remme WJ, Res J, Verheugt FWA, Domburg R, Lubsen J, Hugenholtz PG. 1986. Preservation of global and regional left ventricular function after early thrombolysis in acute myocardial infarction. J Am Coll Cardiol 7:729–742.PubMedCrossRefGoogle Scholar
  5. 5.
    Ishikawa K, Oda A, Kanamasa K, Morishita M, Ono M, Ogawa I, Shimizu M, Koka H, Katori R. 1988. Effect of coronary thrombolysis on left ventricular ejection fraction in patients with acute myocardial infarction. Jpn Circ J 52:1141–1148.PubMedGoogle Scholar
  6. 6.
    Topol EJ, Califf RM, Vandormael M, Grines CL, George BS, Sanz ML, Wall T, O’Brien M, Schwaiger M, Aguirre FV, Young S, Popma JJ, Sigmon KN, Lee KL, Ellis SG, the Thrombolysis and Angioplasty in Myocardial Infarction-6 study group. 1992. A randomized trial of late reperfusion therapy for acute myocardial infarction. Circulation 85:2090–2099.PubMedGoogle Scholar
  7. 7.
    Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group. 1994. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients. Lancet 343:311–322.Google Scholar
  8. 8.
    Richard V, Murry CE, Reimer KA. 1995. Healing of myocardial infarcts in dogs. Effects of late reperfusion. Circulation 92:1891–1901.PubMedGoogle Scholar
  9. 9.
    LATE Study Group. 1993. Late assessment of thrombolytic efficacy (LATE) study with alteplase 6–24 hours after onset of acute myocardial infarction. Lancet 342:759–766.CrossRefGoogle Scholar
  10. 10.
    Topol EJ, Califf RM, Vandormael M, Grines CL, George BS, Sanz ML, Wall T, O’Brien M, Schwaiger M, Aguirre FV, Young S, Popma JJ, Sigmon KN, Lee KL, Ellis SG, TAMI-6 Study Group. 1992. A randomized trial of late reperfusion therapy for acute myocardial infarction. Circulation 85:2090–2099.PubMedGoogle Scholar
  11. 11.
    Reimer KA, Heide RSV, Richard VJ. 1993. Reperfusion in acute myocardial infarction: effect of timing and modulating factors in experimental models. Am J Cardiol 72:13G–21G.PubMedCrossRefGoogle Scholar
  12. 12.
    Nakai S, Ishikawa K, Ogawa I, Koka H, Kamata N, Akiyama H, Katori R. 1995. New collateral flow increasing early after coronary occlusion prevented myocardial necrosis in dogs. Heart Vessels 10:171–177.PubMedCrossRefGoogle Scholar
  13. 13.
    Baandrup U, Olsen EGJ. 1981. Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. Br Heart J 45:475–486.PubMedCrossRefGoogle Scholar
  14. 14.
    Kamata N. 1996. Effect of reperfusion 12 hours after coronary occlusion on myocardial salvage in dogs. Acta Medica Kinki Univ 21:193–203.Google Scholar
  15. 15.
    Reimer KA, Lowe JE, Rasmussen MM, Jennings RB, 1977. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 56:786–794.PubMedGoogle Scholar
  16. 16.
    Hochman JS, Choo H. 1987. Limitation of myocardial infarct expansion by reperfusion independent of myocardial salvage. Circulation 75:299–306.PubMedGoogle Scholar
  17. 17.
    Hale SL, Kloner RA. 1988. Left ventricular topographic alterations in the completely healed rat infarct caused by early and late coronary artery reperfusion. Am Heart J 116:1508–1513.PubMedCrossRefGoogle Scholar
  18. 18.
    Ishikawa K, Kamata N, Nakai S, Akiyama H, Koka H, Ogawa I, Katori R. 1994. Preservation of high regional blood flow at epicardial rim after coronary occlusion in dogs. Am J Physiol 267 (Heart Circ Physiol 36):H528–H534.PubMedGoogle Scholar
  19. 19.
    Maxwell MP, Hearse DJ, Yellon DM. 1987. Species variation in the coronary collateral circulation during regional myocardial ischemia: a critical determinant of the rate of evolution and extent of myocardial infarction. Cardiovasc Res 21:737–746.PubMedCrossRefGoogle Scholar
  20. 20.
    Tiefenbrunn AJ, Sobel BE. 1992. Timing of coronary recanalization. Paradigms, paradoxes, and pertinence. Circulation 85:2311–2315.PubMedGoogle Scholar
  21. 21.
    Weisman HF. Healy B. 1987. Myocardial infarct expansion, infarct extension, and reinfarction: pathophysiologic concepts. Prog Cardiovasc Dis 30:73–110.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Akio Kimura
    • 1
  • Kinji Ishikawa
    • 1
  • Iwao Ogawa
    • 1
  • Hironari Koka
    • 1
  • Shoji Nakai
    • 1
  • Masahiko Inagaki
    • 1
  • Masaru Miyataka
    • 1
  • Takaya Hasegawa
    • 1
  • Ryo Katori
    • 1
  1. 1.Kinki University School of MedicineJapan

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