Effects of BIBR-277, an Angiotensin-II Type-1 Receptor Antagonist, on Ischemic Myocardial Stunning in Dogs

  • Tohru Nakai
  • Kumi Satoh
  • Atsuko Yamamoto
  • Katsuji Hoshi
  • Kazuo Ichihara
Part of the Progress in Experimental Cardiology book series (PREC, volume 1)


BIBR-277, an angiotensin-II type-1 receptor antagonist, improved the recovery of contractile function of the stunned myocardium. Enalapril also lessened the contractile dysfunction during reperfusion in the stunned myocardium. These drugs may act to reduce ischemic damage by removing the systemic and coronary vasoconstrictive effects of angiotensin II.


Left Anterior Descend Coronary Flow Saline Group Stun Myocardium Angiotensin Receptor Antagonist 
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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Tohru Nakai
    • 1
  • Kumi Satoh
    • 1
  • Atsuko Yamamoto
    • 1
  • Katsuji Hoshi
    • 1
  • Kazuo Ichihara
    • 1
  1. 1.Hokkaido College of PharmacyJapan

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