Manganese Superoxide Dismutase Induced by Extracellular Stress Enhances Myocardial Tolerance to Ischemia-Reperfusion
In this chapter, we describe our recent findings showing that an intrinsic radical scavenger, manganese superoxide dismutase (Mn-SOD), is induced in cardiac myocytes in response to various external stresses, such as ischemic (hypoxic) preconditioning, heat shock, and α1-adrenergic stimulation. The induction of Mn-SOD is well correlated with the acquisition of tolerance to ischemia-reperfusion injury of the myocardium. Because inhibition of Mn-SOD induction abolishes the tolerance to ischemia-reperfusion, Mn-SOD plays a pivotal role as a rescue protein in cardiac myocytes, and the induction of Mn-SOD could be an adaptation mechanism against ischemic heart disease.
KeywordsHeat Shock Heat Stress Cardiac Myocytes Antisense Oligonucleotide Manganese Superoxide Dismutase
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- 13.Mutter MM, Sievers RE, Barbosa V, Wolfe CL. 1994. Heat-shock protein induction in rat hearts. A direct correlation between the amount: of beat-shock protein induced and the degree of myocardial protection. Circulation 89:355–360.Google Scholar