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Manganese Superoxide Dismutase Induced by Extracellular Stress Enhances Myocardial Tolerance to Ischemia-Reperfusion

  • Tsunehiko Kuzuya
  • Masashi Nishida
  • Shiro Hoshida
  • Nobushige Yamashita
  • Masatsugu Hori
  • Michihiko Tada
Part of the Progress in Experimental Cardiology book series (PREC, volume 1)

Abstract

In this chapter, we describe our recent findings showing that an intrinsic radical scavenger, manganese superoxide dismutase (Mn-SOD), is induced in cardiac myocytes in response to various external stresses, such as ischemic (hypoxic) preconditioning, heat shock, and α1-adrenergic stimulation. The induction of Mn-SOD is well correlated with the acquisition of tolerance to ischemia-reperfusion injury of the myocardium. Because inhibition of Mn-SOD induction abolishes the tolerance to ischemia-reperfusion, Mn-SOD plays a pivotal role as a rescue protein in cardiac myocytes, and the induction of Mn-SOD could be an adaptation mechanism against ischemic heart disease.

Keywords

Heat Shock Heat Stress Cardiac Myocytes Antisense Oligonucleotide Manganese Superoxide Dismutase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Tsunehiko Kuzuya
    • 1
  • Masashi Nishida
    • 1
  • Shiro Hoshida
    • 1
  • Nobushige Yamashita
    • 1
  • Masatsugu Hori
    • 1
  • Michihiko Tada
    • 1
  1. 1.Osaka University Medical SchoolJapan

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