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ATP-Sensitive Potassium Channels and Myocardial Ischemia

  • Canwen Jiang
  • Philip A. Poole-Wilson
  • Seibu Mochizuki
Part of the Progress in Experimental Cardiology book series (PREC, volume 1)

Abstract

The KATP channel plays an important role in mediating a variety of pathophysiological responses during myocardium ischemia and exhibits cardioprotective effects. As a consequence of the recent cloning of the subunits of the KATP, channel, efforts are being made to understand its properties, regulation, and physiological role in coupling the metabolic state of a cell to excitability. Advances are anticipated in the understanding of the cellular and molecular mechanisms underlying the role of the KATP channel during myocardial ischemia. The modulators of the KATP channel are of great value as therapeutic agents for the treatment of ischemic heart disease. Newly identified tissue-selective KATP channel openers may result in important advances in the treatment of cardiovascular disease.

Keywords

Vascular Smooth Muscle Cell Cardiac Myocytes KATp Channel Ischemic Precondition Action Potential Duration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Canwen Jiang
    • 1
  • Philip A. Poole-Wilson
    • 2
  • Seibu Mochizuki
    • 3
  1. 1.Genzyme CorporationUSA
  2. 2.Imperial College School of Medicine at National Heart and Lung InstituteUK
  3. 3.Jikei University School of MedicineJapan

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