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Bone marrow and stem cell transplantation for multiple myeloma

  • Chapter
Diagnostic and Therapeutic Advances in Hematologic Malignancies

Part of the book series: Cancer Treatment and Research ((CTAR,volume 99))

Abstract

Multiple myeloma is an incurable B-cell malignancy afflicting mainly elderly people with a median age of 65 to 70 years [1]. It is characterized by the proliferation of clonal plasma cells that are resistant to standard doses of commonly employed agents at the time of diagnosis, resulting in complete remission (CR) rates of only 5%–10% and median survival of approximately three years. This inherent resistance is probably due to an array of molecular abnormalities of one or more oncogenes and suppressor genes inhibiting drug induced apoptosis, including ras, myc, p53, Rb, and bc1–2, that have evolved during a prolonged subclinical course of 10–20 years [2]. The recent report of a Kaposi sarcoma-associated herpes virus (KSHV) in the dendritic cells of myeloma patients, whose genome contains the homologue to human IL-6, suggests that the KSHV may also play an important role in the etiology of multiple myeloma [3]. A combination of melphalan and prednisone has been the standard treatment for over 30 years [4]. Permutations of the melphalan/ prednisone regimen by the addition of alkylating agents and anthracyclines have not extended the median survival [5].

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Authors
  1. David H. Vesole
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  1. Northwestern University Medical School, Chicago, Illinois, USA

    Martin S. Tallman M.D.  & Leo I. Gordon M.D.  & 

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© 1999 Kluwer Academic Publishers, Boston

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Vesole, D.H. (1999). Bone marrow and stem cell transplantation for multiple myeloma. In: Tallman, M.S., Gordon, L.I. (eds) Diagnostic and Therapeutic Advances in Hematologic Malignancies. Cancer Treatment and Research, vol 99. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38571-6_7

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  • DOI: https://doi.org/10.1007/978-0-585-38571-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8206-5

  • Online ISBN: 978-0-585-38571-6

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